Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"psychotropic effects"”.
-
CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… of its involvement in mediating the psychotropic effects of marijuana. CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in the CNS and has been targeted therapeutically for multiple diseases; however side effect profiles for CB1R have posed difficulty in …
-
Design, Synthesis And Cannabinoid Receptor Activity Of Benzofuran Ligands
… sativa, it is the primary mediator of the psychotropic effects of marijuana. Conversely, cb2 expression is confined to microglial cells in the brain and predominantly peripheral immune cells. The expression of cb2 provides a pharmacological basis for the well-documented immunomodulatory …
-
Proteomic Identification of Hemp (Cannabis sativa) Seeds by Tandem Mass Spectrometry and Evaluation of Cytotoxic Activity
… contain THC, the compound responsible for its psychotropic effects. This restriction hindered quality research into cannabis and its constituents. The study employed techniques, including top-down proteomics, size exclusion chromatography, affinity chromatography, high-resolution ESI QTOF …
-
Non-Psychotropic cannabinoids attenuate visceral pain in colitis
… potential that do not have the prohibitive psychotropic effects of tetrahydrocannabinol (THC). These non-psychotropic cannabinoids (npCBs) have a variety of effects including analgesia and anti-inflammatory actions and show potentiating effects when administered in combination. This project …
-
Synthesis of fluorinated cannabinoid derivatives; Towards PET radiotracers for imaging the cannabinoid receptor
… represent PET tracer candidates. The adverse psychotropic effects associated with CB1R orthosteric agonists remain a challenge to the development of novel cannabinoid-derived therapeutics leading to the development of GAT211 as CB1R-positive allosteric modulators (PAMs)5,6. In the second part …
-
Optimization and Development of In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2
… has been studied in depth for its therapeutic effects. This has currently been the focus of many researchers since cannabidiol does not cause psychotropic effects. </p> <p>Cannabinoid receptors belong to the large superfamily of G protein-coupled receptors (GPCRs). Approximately 30% of marketed …
-
Cannabinoid Receptor 2 (CB2) Ligands Downregulate Pro-Inflammatory Markers in Stimulated Primary Human Periodontal Ligament Fibroblasts (hPDLFs)
… conditions can benefit from the pharmacological effects of cannabinoids. Plethora of evidence is available for the use of cannabinoids for the anti-inflammatory and immune modulating activity. The targets for therapeutic intervention include the cannabinoid type 1 and 2 receptors (CB1R and CB2R). …