Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"psychostimulants"”.
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A study of an animal model of Attention-Deficit/ Hyperactivity Disorder using in vivo chronoamperometry and behavioural responses to methylphenidate and guanfacine
… due largely to the successes of the use of psychostimulants such as methylphenidate, that increase extracellular levels of dopamine (DA) and/or norepinephrine (NE) for the treatment of symptoms. In this study, the spontaneously hypertensive rat (SHR), the most widely accepted model for ADHD, …
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Attention Deficit Hyperactive Disorder: Alternative Treatment Plans for School Age Children Diagnosed with ADHD
… with high doses of medication in the form of psychostimulants, including amphetamine, methylphenidate, and pemoline. This literature review describes the complexity of ADHD, its symptoms, treatments, and implications on a child’s social and academic development. This review of the literature …
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Monoaminergic Regulation of MeCP2 Phosphorylation in Mouse Models of Psychiatric Disease
… receptors is essential to the mechanism by which psychostimulants and antidepressants induce changes in behavior. Although these drugs rapidly increase monoaminergic transmission, they need to be administered for several weeks or months in order to produce long-lasting alterations in behavior. …
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Methamphetamine and amphetamine differentially affect associative learning: behavioral and neurobiological correlates
… potential differences in the effects of two psychostimulants; methamphetamine (METH) and amphetamine (AMPH). These drugs were chosen because, while structurally very similar, they have differing abuse liabilities. Some of the disparities in rates of use and abuse can be accounted for by …
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The Differential Contribution of Striatonigral and Striatopallidal Neurons in Mediating Responses to Therapeutic Agents and Drugs of Abuse: A Dual Role for DARPP-32
… can affect the phosphorylation of DARPP-32. Psychostimulants such as cocaine increase DARPP-32 phosphorylation at its main regulatory site, T34. Paradoxically, antipsychotics such as haloperidol also increase T34 phosphorylation to a similar degree. Despite this similar biochemical …
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Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder
… both associated with a higher risk of abusing psychostimulants; drugs that act on the dopaminergic system to elicit a sense of reward. Central to dopamine regulation is the dopamine transporter (DAT), which is responsible for the rapid reuptake of released dopamine and therefore the regulation …
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Nicotine Sensitization in β-Arrestin 2 Knockout Adolescent Mice.
… and plays a mediating role in sensitization to psychostimulants and the opiate morphine. In this study, 3-4 week old BA-2 KO and wild type C57/B6 mice received nicotine tartarate (s.c, 0.5 mg/kg free base) for 7 or 14 consecutive days followed by a drug-free period. An acute nicotine challenge …
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Assessment of sex differences and amphetamine on schedule-induced polydipsia
… be more vulnerable to the reinforcing effects of psychostimulants. In the current study, schedule-induced polydipsia (SIP), an animal model of compulsive behavior, was applied for the further study of sex differences in the behavioral effects of AMPH. SIP is a phenomenon whereby food-restricted …
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Identification Of Stimulant Misuse And Malingering Of Symptoms Of Attention Deficit Hyperactivity Disorder
… past year. This study focuses on the abuse of psychostimulants, popularly used for treatment of Attention Deficit Hyperactivity Disorder (ADHD). It is estimated that 10 to 30% of college students might be abusing stimulants, mostly for academic purposes. The incidence of stimulant related ER …
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The effect of voluntary binge caffeine and ethanol coexposure on neurobehavioral sensitivity to cocaine in male C57BL/6J mice
… this is an important question to address. Psychostimulants, such as cocaine, are of particular interest considering the significant involvement of dopamine in their effects. The current project explored this possibility employing an established mouse model of binge caffeine and alcohol …
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The effect of voluntary binge caffeine and ethanol co-exposure on neurobehavioral sensitivity to cocaine in male C57BL/6J mice
… this is an important question to address. Psychostimulants, such as cocaine, are of particular interest considering the significant involvement of dopamine in their effects. The current project explored this possibility employing an established mouse model of binge caffeine and alcohol …
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INVESTIGATIONS INTO THE STEREOCHEMICAL AND GLUTAMATERGIC MECHANISMS OF THE "BATH SALTS" SYNTHETIC CATHINONES MEPHEDRONE AND MDPV IN RATS
… marketed as “legal high” alternatives to illicit psychostimulants (ie. cocaine and MDMA). Two of the most common synthetic cathinones since the emergence of this class of drugs are 4-methylmethcathinone (mephedrone, MEPH) and 3,4-methylenedioxypyrovalerone (MDPV). The novelty of these compounds in …
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Design, Synthesis, Biological Evaluation and Metabolic Stability Studies of Sigma Receptor Ligands
… in the behavioral and motivational effects of psychostimulants as well as in the pathophysiology of depression and Alzheimer's disease. Sigma-2 receptors are widely expressed on many tumor cells and they are believed to play an important role in tumor cell proliferation. Therefore, sigma …
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A comparison of two forms of treatment for children with attention deficit hyperactivity disorder: effects on executive functioning and behaviour
… the efficacy of interventions, including psychostimulants and multimodal treatments (medication and behavioural therapy). Whilst the short term efficacy of these treatments is supported, there is a relative absence of convincing empirical evidence to support long term treatment in …
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Parental Decision Making in the Administration of Stimulant Medication for their Latency Age Children with Attention Deficit Hyperactivity Disorder (ADHD)
… Disorder (ADHD). Research has shown that psychostimulants, used to treat ADHD are effective for 75-90% of children (US Department of Health and Human Services, 2001), however children do not take their medication from 20-65% of the time. A qualitative study using a type of grounded theory, …
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Alterations in executive functioning induced by repeated amphetamine exposure
Chronic exposure to psychostimulants such as amphetamine (AMPH) can induce long-term disruptions in cognition via actions on prefrontal cortex dopamine. Previous work has shown that two types of executive functions, set shifting and working memory (WM), are disrupted by AMPH sensitization and that …
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Anatomical and Functional Characterization of the Ventral Hippocampus in a Rodent Model of Schizophrenia Neuropathology
… mice showed an increased sensitivity to some psychostimulants and a weak trend for metabolic abnormalities relevant to schizophrenia. We conclude from the rat studies that prenatal disruption of brain development by MAM at E17 in the rat, a manipulation that leads to a profile of gross …
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Behavioural, Pharmacological, and Immunohistochemical Investigation of 50 kHz USVs as an Expression of Positive Emotional Arousal in the Long Evans Rat
… 50 kHz USVs and call rate typically induced by psychostimulants. In chapter 5, I used a minimal sensitization protocol with amphetamine to establish that 50 kHz USVs and measures of general ergometric activity could be dissociated. Additionally, in chapter 5 I attempted to find brain region …
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The economic behaviour of poly-drug users in the Western Cape: an analysis of pathways, prices, location and gender
… large. Improved data on the markets for illicit psychostimulants are imperative for supporting policy efforts to manage their use and provide support structures for those affected. This thesis is one of the few detailed studies on the South African drug market using quantitative methods. It …
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