Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"pseudomembranous colitis"”.
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Clostridium difficile toxins A and B: exploring the possible mechanism of action
… occasionally causes the life-threatening disease pseudomembranous colitis. The pathogenicity of the organism has been attributed to the production of two large exotoxins, toxin A (308,000 daltons) and toxin B (269,000 daltons). Toxin A is a powerful enterotoxin and is generally thought to play the …
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Characterization of the carbohydrate receptors of the <i>Clostridium difficile</i> enterotoxin
Clostridium difficile causes pseudomembranous colitis in humans and a similar ileocecitis in hamsters. This organism can colonize the intestines after antibiotic therapy disrupts the normal intestinal microflora. Once established in the intestines, the organism causes disease by producing two …
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Towards Phage Therapy: Characterization of Clostridioides difficile Bacteriophages from a South African Strain Collection
… bacillus, with conditions including diarrhoea, pseudomembranous colitis, and toxic megacolon. Antibiotic resistance has been reported for the standard of care antibiotics, while newer drugs are too costly for resource-limited clinical settings. Faecal microbiota transplantation (FMT) is highly …
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Purification and characterization of Clostridium sordellii toxins HT and LT and comparison to toxins A and B of Clostridium difficile
… This organism was once believed to cause pseudomembranous colitis (PMC) in humans, however, Clostridium difficile, not C. sordellii, was found to be the causative agent of this disease. It is now known that C. difficile produces two toxins, designated A and B, that are implicated in the …
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Effect of Autoregulated TxeR on the Expression of <I>Clostridium difficile</I> Toxins
… nosocomial pathogen responsible for causing pseudomembranous colitis. It is estimated that 25% of antibiotic-associated diarrhea is due to C. difficile. These diseases result from intestinal tissue damage caused by two of the largest known bacterial toxins, A and B. Molecular studies of the …
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Identification of Operons in clostridium difficile
… that causes severe, toxin-mediated diarrhea and pseudomembranous colitis. Previous studies of pathogenic bacteria, including C. difficile, have investigated the operon structures and their roles in drug resistance and pathogenicity. Despite significant progress in understanding the genome and …
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Identification and characterization of a receptor for Clostridium Difficile enterotoxin
… and its toxins are implicated as the cause of pseudomembranous colitis in patients undergoing antibiotic therapy. Very little information is known about how these toxins bind to cells and cause disease. In an attempt to understand how these toxins work this dissertation research was undertaken …
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Serum Complement Reactive Protein (CRP) Trends Following Free Flap in Lower Extremity Reconstruction
… had side effects of antibiotics (drug fever and pseudomembranous colitis) and also displayed a high level of CRP, which subsequently lowered slowly. In these four complication cases, a change in antibiotics guided by a consultant microbiologist was necessary. In all disease-free patients, mean …
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Clostridium difficile: expression of virulence factors, resistance to disinfectants and interactions with human cells
… carriage and mild infection to severe pseudomembranous colitis have been observed. The main aim of this three-part thesis was to identify bacterial factors that might explain these variations by comparing five C. difficile strains - strain 630, an historic strain, strain VPI 10463, a …
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The acquisition of clostridium difficile-associated disease: the role of nutritional care
… the discovery of C. difficile pathogenesis in pseudomembranous colitis in the 1970’s, have shown waning effectiveness and may actually increase disease recurrence and treatment failure. Interest in non-antibiotic alternatives, the evolving understanding of the microbiome as a critical defense …