Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"pseudokinase"”.
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The Effects of Chromatin Remodeling and Pseudokinase Activity on Liver Pathophysiology
… screening within the liver to identify the pseudokinase STK31 as a positive regulator of hepatocyte proliferation and liver oncogenesis. Our findings underscore the important role that chromatin remodeling has in enforcing hepatocyte identity and functionality as well as allowing for …
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UNDERSTADING THE ROLE OF PSEUDOKINASE TRB3 IN CANCER PROGRESSION AND CHEMORESISTANCE DURING METABOLIC STRESS
… catalytic activity, thus their classification as pseudokinases. Despite their catalytic inactivity, Tribbles can interact with different proteins and regulate different biological functions. The most studied tribble family member, Trb3, was reported to play a major role in Drosophila's ventral …
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Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets
… the Myddosome. Subsequently, IRAK kinases and pseudokinases recruit and activate a number of E3 ubiquitin ligases that trigger downstream signalling events to induce the production of pro- and anti-inflammatory mediators. The emergence of crystal structures and development of specific …
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The role of organelle crosstalk in a Drosophila model of Parkinson’s disease
… acts as an inhibitor of Akt, implicating this pseudokinase as a negative regulator of insulin signalling. The human Trbl orthologue tribbles pseudokinase 3 (TRIB3) is upregulated in insulin resistant as well as obese adults, and TRIB3 polymorphisms are associated with type 2 diabetes and …
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TRIB3 as an integrator of metabolic stresses: Role in lung cancer progression
The pseudokinase Tribbles pseudokinase 3 (TRIB3) is known as a regulator in cellular responses to a variety of stresses such as glucose insufficiency and (ER) stress. Recent studies reported an increased expression of TRIB3 in cancers and its correlation with the poor prognosis in cancer patients. …
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Structure of the LKB1-STRAD-MO25 tumour suppressor complex
… kinase that is activated by binding to the pseudokinase STRAD and the scaffolding protein MO25. LKB1 activates AMPK and twelve other members of the AMPK family of kinases, thus controlling cellular energy and cell polarity. Much attention has been focused towards protein kinases activated by …
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With No Gly-Loop Family of Kinases
… By solving the crystal structure of a pseudokinase in the WNG1 family, I show members adopt an atypical protein kinase fold lacking the glycine rich ATP-binding loop that is required for catalysis in canonical kinases. Unexpectedly, I find that WNG1 is an active protein kinase that …
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Evasion of interferon-gamma responses by Toxoplasma gondii in murine and human fibroblasts
… factors, the protein kinase ROP18 and the pseudokinase ROP5, determine IRG evasion. We demonstrate that ROP5 binds to and inhibits the oligomerization of Irga6, allowing ROP18 to phosphorylate the IRGs to inhibit PV accumulation. However, humans lack interferon-inducible IRGs, and ROP5 and …
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Optimization of Receptor-Interacting Protein Kinase 2 (RIPK2) Inhibitors and Development of Mixed Lineage Kinase Domain-Like (MLKL) Activators
Protein kinases and pseudokinases play pivotal roles in complex cellular signaling and regulatory pathways. Protein kinases’ catalytic activity is critical for controlling a myriad of cellular events and functions. Despite a lack of catalytic activity, pseudokinases have merged as nuanced …
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Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
… Two proteins, mixed lineage kinase domain-like pseudokinase (MLKL) and DmX-like protein 1 (DMXL1), were then selected for further mechanistic and functional characterisation. MLKL is the terminal effector of a form of cell death called necroptosis. Many herpesviruses suppress necroptotic …
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The Role of GRA7, a Component in the ROP18 Protein Complex, in Toxoplasma gondii
… partners with two parasite proteins, the rhoptry pseudokinase ROP2, and the dense granule protein GRA7. While GRA7 arises from a distinct organelle intracellularly, upon infection, we were able to localize GRA7 to the cytosolic face of the PVM similar to ROP18, using selectively permeable …
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Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
… cell death: mixed lineage kinase domain-like pseudokinase (MLKL) and mitochondrial apoptosis-inducing factor (AIF). Inhibiting RIP3 by an FDA approved anti-cancer drug, dabrafenib, reduced both acid-induced death of mouse cortical neurons <em>in vitro</em> and brain infarction in mice …
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An investigation of the role of TRIB2 in steady state and stressed haematopoiesis
… mammalian Tribbles family of serine/threonine pseudokinases (TRIB1-3). Here, we studied murine haematopoiesis after Trib2 ablation under steady state and proliferative stress conditions, including genotoxic and oncogenic stress. At the steady state, we found that TRIB2 loss did not adversely …