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Showing 1 to 1 of 1 for “"proximity pharmacology"”.
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Developing Computational Methods in Proximity Pharmacology for Enzyme Discovery, PROTAC Screening, and Conformational Space Exploration
… Phase 3 trials. Beyond degradation, the field of proximity pharmacology explores the recruitment of other enzymes, such as kinases, to induce post-translational modifications. While computational methods have accelerated small molecule discovery and optimization, heterobifunctional compounds pose …