Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"proximal tubule"”.
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Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension
… aim of this study was to determine the role of proximal tubule transporters on the renal sodium handling in obese hypertensive (OP) and lean normotensive (OR) rats. An acute increase in renal perfusion pressure resulted in a blunted natriuretic response in OP vs. OR rats and indicated that …
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A ROLE FOR ANGIOTENSIN-(1-7) TO ATTENUATE ADVANCED GLYCATION END PRODUCT -INDUCED MYOFIBROBLAST TRANSITION IN THE NRK-52E RENAL PROXIMAL TUBULE CELL LINE
… to mesenchymal transition (EMT) of the proximal tubules cells. Advanced glycated end product (AGEs) including methylglyoxal-modified albumin (MGA) may contribute to the development and progression of diabetic nephropathy via activation of the receptors for AGE (RAGE) and the RAS. The RAS …
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Stress response genes in the human proximal tubules
… was to determine if the immortalized HK-2 human proximal tubule cell line could provide a model system to study the stress response of the proximal tubule cell. Heat stress, elevated temperature at 42.5°C for 1 hr, caused a marked increase only in hsp 70 mRNA and protein, but not that of hsp …
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Characterization of Understudied Risk Factors in Chronic Kidney Disease
… tubulointerstitial pathways in which the proximal tubule fails to complete adaptive repair after repeated subclinical acute kidney injury (AKI). The current hypothesis is that CKDu manifests hot, agricultural regions, where recurrent heat/dehydration interacts with local environmental …
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Identification of Acyloxyacyl Hydrolase, a Lipopolysaccharide Detoxifying Enzyme, in the Murine Urinary Tract
… presented here, AOAH was found in murine renal proximal tubule cells and in human renal v cortex. Proximal tubule cells are known targets for invading Gram-negative uropathogens and we hypothesize that possessing AOAH may help them degrade the LPS contained within these bacteria. I further found …
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Proteins and instability elements involved in phosphoenolpyruvate carboxykinase mRNA turnover
… of the PCK-1 gene; while in the renal proximal tubule, it is regulated by hormones including parathyroid hormone, and angiotensin II. The transcriptional regulation of the PCK-1 gene is well studied; however there is very little information about the factors that regulate the turnover …
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Pharmacological Studies of the Signal Transduction Pathways of the a 1a-Adrenbrgic Receptor Subtype
… has been shown to be present in the renal proximal tubules. However, the functions and signal transduction pathways of a1a-ARs in the renal proximal tubule cells are not well understood. In my project, 1 first developed a renal proximal tubule cell model transfected with epitope …
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3D KIDNEY ORGANOIDS AS A PLATFORM FOR INVESTIGATING MONOGENIC DISEASES AND GENE THERAPY APPROACHES
… and characterised kidney organoid models of proximal tubulopathies such as Lowe syndrome, Fabry disease, and Cystinosis. These were characterised at the morphological and functional level, displaying pathology-relevant phenotypes useful for validating therapies such as Enzyme Replacement …
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STUDIES ON ANGIOTENSIN-(1-7) AND MITOCHONDRIA: THE ROLE OF AN INTRACELLULAR RENIN-ANGIOTENSIN SYSTEM WITHIN THE KIDNEY
… activity in the kidney, specifically in the proximal tubules and in a human proximal tubule cell line. Utilizing the human tubule cells, we purified and identified the Ang-(1-7) degrading activity as Dipeptidyl-Peptidase 3 (DPP 3). Given the bioactive role of Ang-(1-7) counteracting the …
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Pengaruh pemberian infusa daun murbei (Morus alba L.) terhadap gambaran histologi gromerulus dan tubulus proksimal tikus putih (Rattus norvegicus) diabetes mellitus kronik
… can damage the structure of the kidney involving proximal tubule and the glomerulus. It was necessary for the intake of natural antioxidants derived from mulberry leaves the plant. Mulberry leaf contains many active substances include BNJ that is able to reduce blood sugar level and contains …
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Ageing and regeneration-associated transcriptional state transitions and tumour-stroma interaction in early renal carcinogenesis
… these 4 TFs showed upregulation in normal proximal tubule (PT) cells as mice get older. The second wave showed upregulation of Sox4 and Sox9, which are involved in kidney epithelial cell regeneration. Single cell ATAC sequencing (scATAC-seq) experiment confirmed the functional importance of …
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Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
… peptide GDF15 by a subset of kidney proximal tubule (PT) cells. Blocking this response with a GDF15 antibody alleviates cachexia in Adh5-/-Csbm/m mice. Therefore, CSB provides protection to the kidney and brain against DNA damage caused by endogenous formaldehyde, whilst also …
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Compensatory renal hypertrophy, mitochondria and redox status
… with increased susceptibility of renal proximal tubule cells to several drugs and environmental chemicals. Furthermore, our lab also showed that overexpression of mitochondrial GSH transporters, the dicarboxylate (DIC, Slc25a10) and 2-oxoglutarate (OGC, Slc25a11) carriers, in NRK-52E …
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Characterization of the prostacyclinIP receptor system in the rat kidney: Implications for diabetic nephropathy
… vasculature, and cortical and medullary tubules on rat tissue sections, and in different preparations: kidney (C: cortex, OM: outer medulla, and IM: inner medulla), cultured MG (primary and transformed), proximal tubule (PT; fresh and cultured), and inner medullary collecting duct (fresh: …
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… C21 rescues megalin surface expression in the proximal tubules potentially by activating Akt-mediated phosphorylation and inactivation of GSK3β in the kidney of male obese Zucker rats fed HSD for 48 hrs. The HSD intake resulted in proteinuria, which was significantly prevented by C21. Moreover, …
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An analysis of the mechanisms of acute kidney injury and novel biomarkers
… NGAL have the ability to indicate damage to the proximal tubule. Along with the ability to provide information as to the specific site of renal injury, the levels of cystatin C, KIM-1, and NGAL increase much more rapidly and to a much higher value than serum creatinine once physical renal damage …
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Reactive Oxygen Species-Induced Necrotic Cell Death
… TGHQ-mediated cell death in human renal proximal tubule epithelial HK-2 cells. TGHQ induced ROS generation, DNA strand breaks, hyperactivation of PARP-1, rapid depletion of nicotinamide adenine dinucleotide (NAD), elevations in intracellular Ca2+ concentrations, loss of mitochondrial …
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Freeform, direct-write assembly of thermoplastics and glasses: Theory, practice, and applications
… create a tissue-engineered model of the kidney proximal tubule.
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Acyloxyacyl Hydrolase: Studies on Its Regulation and Function in Mus Musculus
… also produced by monocyte-macrophages and renal proximal tubule cells. In the studies described here, I found that both immature dendritic cells (DCs) of the XS52 cell line and bone marrow-derived DCs produce AOAH. AOAH expression decreased when DCs were incubated with IL-4, IL-1ᬠTNFa and an …
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Studies on renal progenitor cells and kidney cancer
… has an endogenous ability to repair damaged tubules and restore kidney function, provided that the patient receives adequate supportive care in time. The molecular basis for this regeneration process is still not fully elucidated and the cellular origin for regeneration is extensively …
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