Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"proximal tubular cells"”.
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Studies of immunoglobulin receptors and human proximal tubular cells
… the hypothesis that an interaction between tubular cells and filtered Ig/immuno complex (Ig/IC) may involve specific cellular receptors, and thus provide a novel mechanism for the initiation of tubular injury and fibrosis. Deposition of Ig and IC is seen in renal diseases such as membranous …
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Taurocholat-Transport in isolierten proximalen Tubuluszellen der Ratte : Einfluss einer extrahepatischen Cholestase
… in the glomeruli. The bile acids reaching the tubular fluid are nearly completely reabsorbed by the apical sodium-dependent bile salt transporter (asbt). Hence, with normal conditions, urinary excretion of bile acids is negligible low. During extrahepatic cholestasis, when bile acid …
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Regulation des renalen Natrium-abhängigen Gallensäuren-Transporters (ASBT) durch Sexualhormone und Glukokortikoide
… escape urinary excretion due to an effecient tubular reabsorption process, which help to conserve bile acids. Reabsorption is mediated by the sodium-dependent bile acid transporter (ASBT) localized in the apical brush border membrane of the proximal tubular cell. The aim of the present study …
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Vascular Mechanisms of Rhabdomyolysis-induced Acute Kidney Injury
… and glomerular filtration rate (GFR) reduction, tubular injury, and acute kidney injury (AKI). The mechanisms that underlie rhabdomyolysis-induced AKI are not fully understood but may involve the local production of vasoactive mediators in the kidney. Myoglobin stimulated endothelin-1 (ET-1) …
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Studies on renal progenitor cells and kidney cancer
… a new cell type intermingled between the proximal tubular cells of the nephron in normal human kidney. These cells share marker expression with regenerating tubules and display stem cell-like abilities as well as distinct morphological properties, such as low mitochondrial content and …
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3D KIDNEY ORGANOIDS AS A PLATFORM FOR INVESTIGATING MONOGENIC DISEASES AND GENE THERAPY APPROACHES
… research. These models enable the study of human cells under more physiologically relevant conditions and allow for early proof-of-concept testing of therapies prior to animal studies. While 3D models do not replace traditional 2D or animal models, they represent a powerful complement. Here, we …
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Compensatory renal hypertrophy, mitochondria and redox status
… with increased susceptibility of renal proximal tubule cells to several drugs and environmental chemicals. Furthermore, our lab also showed that overexpression of mitochondrial GSH transporters, the dicarboxylate (DIC, Slc25a10) and 2-oxoglutarate (OGC, Slc25a11) carriers, in NRK-52E …