Global ETD Search
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Showing 1 to 6 of 6 for “"proviral integration"”.
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Pim Kinase Inhibition: Single Agent and Combination Approaches In B-Cell Lymphoma
<p>Proviral integration site for Moloney murine leukemia virus (Pim) kinases are Ser/Thr/Tyr kinases. They modulate B-cell development but become oncoproteins and promote cancer development once overexpressed. Containing three isoforms, Pim-1, -2 and -3 are known to phosphorylate various substrates …
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Genetic and Biochemical Analysis of the Bryan Strain of Rous Sarcoma Virus
<p>Integration of Rous sarcoma virus DNA into its host genome was analyzed under conditions where secondary integration via virus spread was inhibited. This was accomplished by using the noninfectious pol<sup>-</sup>, env<sup>-</sup> alpha variant of the Bryan high titer strain of Rous sarcoma …
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Integration Sites in the Persistence of Latent HIV-1
… The work herein elucidates the contribution of proviral integration site to HIV-1 latency and the maintenance of the replication-competent, or intact, reservoir. Using an innovative single-cell sequencing technique that provides paired proviral sequence and integration site information, as well …
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Enrichment and Transcriptome Analysis of CD4+ T Cell Clones Harboring Intact HIV-1 Proviruses
… them apart from uninfected CD4+ T cells. Thus, proviral integration does not appear to shape the host cell neither in a uniform, nor in a unique way.</p>
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Regulation of the oncogenic PIM1 kinase by SUMOylation
PIM1 (Proviral Integration site for Murine leukemia virus site 1) is a constitutively active serine/threonine protein kinase that is induced physiologically by the JAK-STAT and NF-κB pathways. PIM1 mediates<br/>survival signalling in cells, and contributes to the development of resistance towards …
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Strategies for Oncogenesis by Avian Leukosis Viruses
… importantly, tumors from different birds had integration sites in common. Tumor cells synthesized high levels of discrete new poly(A) RNAs consisting of viral S' sequences covalently linked to cellular sequences. No virus capable of transforming tissue culture fibroblasts or of inducing tumors …