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Showing 1 to 20 of 38 for “"protozoan parasites"”.
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Flagellum assembly in protozoan parasites
… and haploid genome organisation in malaria parasites.
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Studies on protozoan parasites of small mammals
Studies on several different protozoan parasites of small mammals,moles (Talpa europaea), bank voles (Clethrionomys glareolus), fieldvoles (Microtus agrestis), field mice (Apodemus sylvaticus), mice,rats and rabbits are described in this study.In the mole (Talpa europaea) three parasites were …
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Solution and solid-phase synthesis of potential carbohydrate vaccines for leishmaniasis and malaria
… people worldwide, and is caused by unicellular protozoan parasites. Cell surface carbohydrates are implicated in immune recognition of the parasite by host macrophages. The synthesis of a unique tetrasaccharide found on the parasite cell surface lipophosphoglycan is described. The synthetic …
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Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds
… The antiquity of malaria, which is caused by protozoan parasites of the genus Plasmodium, is demonstrated by the host specificity of over 100 parasite species found in reptiles, birds and mammals. The four species of plasmodia that infect man are P. vivax, P. malariae, P. ovale and P. …
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Patterns of avian haemosporidia in birds within the greater Cape Town area
… richest diversity of intracellular, single cell, protozoan parasites with complicated life cycles, changing between the vector as definitive host (blood-feeding arthropod) and bird as intermediate host. Avian haemosporidian parasites belong to the order Haemospororida, to which the families …
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Synthesis of aminomethylthiazole analogues for evaluation as antiplasmodial agents
… The disease is caused by five species of protozoan parasites of the genus Plasmodium with Plasmodium falciparum being the most virulent. Among the many shortfalls of current antimalarial drugs, the emergence of drug resistant strains of the malaria parasites is the most disturbing. Thus, …
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Characterization of subtilisin-like serine proteases in trichomonas vaginalis
… viability. Published data of other eukaryotic protozoan parasites confirm the importance of subtilases for adhesion and invasion. Serine protease inhibitor assays show that 3,4 DIC and TPCK inhibited cell growth from 79.6 to 98.4% respectively. To examine subtilases in more detail, a number of …
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Factors affecting the protective effect provided by sand fly saliva immunization on the outcome of Leishmania infection
… VERSION Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania, transmitted by its vector - female sand flies during the process of blood feeding. Preexposure to sand fly saliva prior to Leishmania infection affects the host immune system, leading to possible …
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Cryptosporidium sp. and Giardia sp. in the St. Lawrence River: Impact on drinking water quality.
… describe the occurrence and distribution of the protozoan parasites Cryptosporidium sp. and Giardia sp. in raw and treated water supplies on the St. Lawrence River; (b) to find a suitable microbial indicator for the presence of Cryptosporidium sp. and Giardia sp. in raw water; (c) to measure the …
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New aminoquinoline antimalarial cysteine protease inhibitors based on the isatin natural product scaffold
… to inhibit cysteine proteases from mUltiple protozoan parasites. Synthesized compounds were tested against the enzyme falcipain-2 (Rec-FP-2) as well as the parasite source of this protease, Plasmodium Jalciparum (P.f. W2). The results of structure activity relationship studies demonstrate the …
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Renal Risk Variants of Apolipoprotein L-1 Form Channels at the Plasma Membrane that Lead to a Cytotoxic Influx of Calcium
… protein that provides protection against several protozoan parasites due to its channel forming properties. Recently evolved variants, G1 and G2, increase kidney disease risk when present in two copies. In mammalian cells, overexpression of G1 and G2, but not wild-type G0, leads to swelling and …
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The role of the flagellum attachment zone in Leishmania mexicana flagellar pocket architecture
Leishmania spp are flagellate protozoan parasites, with a digenetic life cycle, alternating between a mammalian host and insect vector. Within both the host and vector Leishmania adopts different morphologies and cell types, which are adapted to that ecological niche. One of the key architectural …
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Single and hybrid antimalarials based on artemisinin, chloroquine and ß-lactams : synthesis, antiplasmodial activity, cytotoxicity and effect of selected artemisinin-chloroquine hybrids on the parasitic endocytosis pathway
… throughout recorded history. It is caused by protozoan parasites of the genus Plasmodium, where P. falciparum is the most lethal. Current estimates are that over 500 million people are afflicted, while 3 million people die annually. With the emergence of resistance to antimalarial drugs in the …
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Feline Parasitism: Parasite Prevalence and Evaluation of New Immunoassays for Giardia and Cryptosporidium
Cats are infected with a variety of internal parasites, some of which are zoonotic. Therefore, being able to effectively detect and determine prevalence of internal parasites in cats is important for both feline and human health. Some parasites are easier to detect than others. Diagnosing Giardia …
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Comparative efficacy of azole compounds targeting sterol 14-demethylase against multiple isolates of Acanthamoeba castellanii and polyphaga
… the genus Acanthamoeba are normally free-living protozoan parasites, found ubiquitously in the environment. However, they are also have the ability to parasitise humans where they cause a variety of diseases depending upon the anatomical site of infection and the immune status of the host. The …
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Development of a Turkey Coccidiosis Vaccine Candidate: an Attenuated Line of the Protozoan Parasite, Eimeria meleagrimitis
… important enteric disease of poultry caused by protozoan parasites belonging to the genus Eimeria. Drugs are most commonly used to control coccidiosis. Widespread usage of anticoccidial drugs in the field has resulted in development of drug resistant strains and consequently decreased drug …
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Leishmania CRK3:CYC6 cyclin-dependent kinase as a drug target
Leishmania species are protozoan parasites which have a complex life cycle, which is coordinated with its cell cycle. There are 11 cyclin dependent kinases (CDKs) and 11 cyclins present in the Leishmania genome reflecting the complexity of cell cycle control in this parasite, perhaps due to the …
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Gregarine parasitism in dragonfly populations of Central Texas with an assessment of fitness costs in Erythemis simplicicollis.
Dragonfly parasites are widespread and frequently include gregarines (Phylum Apicomplexa) in the gut of the host. Gregarines are ubiquitous protozoan parasites that infect arthropods worldwide. More than 1,600 gregarine species have been described, but only a small percentage of invertebrates have …
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Characterization of Host Immune Responses to Eimeria adenoeides Infection in Turkey Poults
… enteric disease of turkeys that is caused by protozoan parasites belonging to the genus <em>Eimeria</em>. There are about seven species of <em>Eimeria</em> that affect turkeys and of these <em>E. adenoeides</em> is the most pathogenic and commonly recognized. Infection with <em>Eimeria</em> is …
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Development of a plant-based vaccine against malaria
… human disease reported worldwide, caused by protozoan parasites. Half of the world's population is at risk of malaria, and more than 200 million new cases are reported annually. Currently, there are no licensed vaccines available for use. Therefore, there is a vital need for developing an …
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