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Showing 1 to 20 of 84 for “"protozoan parasite"”.
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Transcript Diversity In The Protozoan Parasite Toxoplasma Gondii
… of mRNA-seq data from the obligate intracellular protozoan parasite Toxoplasma gondii, a ubiquitous pathogen of humans and other vertebrates. We produced and sequenced 24 strand-specific RNA libraries from several parasite strains and developmental stages, and examined these in conjunction with 45 …
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Protein coding transcription and control of vsp gene expression in the protozoan parasite Giardia lamblia
Giardia lamblia is an early branching eukaryote and although distinctly eukaryotic in its cell and molecular biology, transcription in G. lamblia demonstrates important differences from these processes in higher eukaryotes. α-amanitin is a relatively selective inhibitor of eukaryotic RNA Polymerase …
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Growth regulation in the protozoan parasite Trypanosoma brucei: Evidence of tyrosine-specific protein kinase activity
… signals to a cell's interior. Until recently, protozoan organisms were thought not to possess tyrosine-specific protein kinases. This investigation demonstrates that Trypanosoma brucei, a protozoan parasite, has a tyrosine-specific protein kinase that plays a role in regulation of proliferation …
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Characterization of the effects of Interferon gamma protein-10 (CXCL10) against the protozoan parasite Leishmania amazonesis
… mice showed decreased numbers of L. amazonensis parasites, which was partially due to increased nitric oxide production, as well as elevated production of pro-inflammatory chemokines. When susceptible C57BL/6 mice were locally injected with CXCL10 following L. amazonensis infection, there was a …
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Patterns of helminth and protozoan parasite infections in bighorn sheep, Ovis canadensis: sex, season and activity
… sexes may be more susceptible/ less tolerant to parasites at different times of the year. Since this is an observational study, I will be using fecal egg counts (FEC) in terms of eggs per 4 grams (EP4G) as a proxy for susceptibility/tolerance. Furthermore, when individuals have higher parasite …
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Development of a Turkey Coccidiosis Vaccine Candidate: an Attenuated Line of the Protozoan Parasite, Eimeria meleagrimitis
… important enteric disease of poultry caused by protozoan parasites belonging to the genus Eimeria. Drugs are most commonly used to control coccidiosis. Widespread usage of anticoccidial drugs in the field has resulted in development of drug resistant strains and consequently decreased drug …
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Development and characterization of novel toxoplasma gondii inhibitors
… gondii</italic> is an obligate intracellular, protozoan parasite of the phylum Apicomplexa. While the parasite relies on the feline to complete its life-cycle, many mammals can contract the infection. In humans, infection can cause serious illness or death. Treatments currently available are …
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Investigation of the expression of DMC1, a meiotic gene, in trichomonas vaginalis
<p>T. vaginalis is a protozoan parasite without an observed sexual stage in its life cycle. However, T. vaginalis has genes, such as Dmc1, known to be involved in meiosis in other organisms. In order to look at the expression of these genes in T. vaginalis, RT-PCR was done using purified mRNA. It …
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The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics.
Leishmania major is a protozoan parasite and infection in the human host causes severe cutaneous Leishmaniasis. The study aims to determine how signaling via the IL-4Rα on CD4+T cells causes susceptibility to L. major. We compared gene expression patterns early during infection in CD4+ T cells in …
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Giardia Cathepsins and Their Role in Intestinal Disease
Giardia duodenalis, a non-invasive protozoan parasite of the upper small intestine of mammals, including humans, closely associates with intestinal epithelial cells. The pathophysiology of giardiasis includes intestinal barrier dysfunction and cytoskeletal injury; however, the mechanisms or …
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Functional Education of Monocytes During Infection
… during acute gastrointestinal infection with the protozoan parasite Toxoplasma gondii, recruited monocytes not only contributed to parasite control, but also regulated pathologic immune responses to commensal microbes via secretion of the lipid mediator prostaglandin E2 (PGE2). Priming of …
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A Phosphoinositide-Specific Phospholipase C of Trypanosoma Cruzi: Unique Characteristics of a Delta-Type Homologue
… phospholipase C gene (TcPI-PLC  ) of the protozoan parasite Trypanosoma cruzi was cloned, sequenced, expressed in E. coli, and the protein product (TcPI-PLC) was shown to have enzymatic characteristics similar to those of mammalian delta-type PI-PLCs. The TcPI-PLC gene is expressed at high …
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Development and characterization of an inducible RNAi system in Toxoplasma gondii
Toxoplasma gondii is a ubiquitous protozoan parasite that can infect and replicate within any nucleated mammalian or avian cell. The ability of double stranded RNA to downregulate gene expression has been demonstrated in T. gondii. We have constructed a tetracycline based inducible RNAi vector …
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A Stochastic Model for The Transmission Dynamics of Toxoplasma Gondii
Toxoplasma gondii (T. gondii) is an intracellular protozoan parasite. The parasite can infect all warm-blooded vertebrates. Up to 30% of the world's human population carry a Toxoplasma infection. However, the transmission dynamics of T. gondii has not been well understood, although a lot of …
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Inducible immunity to Trichomonas vaginalis in a mouse model of vaginal infection.
Trichomonas vaginalis is a protozoan parasite that causes a common sexually transmitted disease, trichomoniasis. Despite its high prevalance, the pathogenesis and immunogenicity of T. vaginalis are not well understood. Because currently available therapies are not always effective in treatment or …
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The application of computerized geographic information systems to epidemiological surveillance of cattle diseases caused by <i>Theileria Parva</i>
Cattle diseases caused by the protozoan parasite <i>Theileria parva</i> and transmitted by the brown ear tick <i>Rhipicephalus appendiculatus</i> are among the most costly diseases in eastern, central and southern Africa. The control of these diseases in areas where they occur, and the prevention …
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Biological studies of GPI-anchoring in Trypanosoma cruzi
Trypanosoma cruzi, a protozoan parasite transmitted to humans via triatomine\r\ninsects, causes chronic chagasic cardiomyopathy (CCM) in ~30% of infected individuals.\r\nThis dissertation sought to characterize T. cruzi’s pathogenic mechanisms by cellular,\r\nbiochemical, and molecular genetics …
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Investigation of conserved Flagellum proteins in Trypanosoma brucei
The single celled protozoan parasite Trypanosoma brucei is an excellent model organism to study eukaryotic cilia and flagella as it has a single flagellum that remains assembled throughout the cell cycle. The new flagellum assembles in a known position relative to the old flagellum, therefore …
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