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Showing 1 to 20 of 40 for “"protoporphyrin"”.
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Studies of the Chlorophyll Biosynthetic Pathway Between Protoporphyrin Ix and Magnesium-Protoporphyrin Ix Monoester
Made available in DSpace on 2015-05-14T15:10:00Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7821247.PDF: 3642484 bytes, checksum: fb3fd656cbb61635a722e7cf0f540511 (MD5) Previous issue date: 1978
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Protoporphyrin IX distribution in rat brain following the administration of 5-aminolevulinic acid and its hexylester
Rowett nude rats were injected intra-cranially with varying concentrations of 5-aminolevulinic acid (10, 20, 99, 199, 398 mM) and its hexylester (6.6, 13, 66, 132, 265 mM). Toxicity effects of these compounds were examined based on animal behavior and respiratory distress. It was determined that …
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Dynamics of oxygen penetration and diffusion into horse skeletal myoglobin revealed by quenching of zinc protoporphyrin IX fluorescence
… associated with these fluctuations. We used zinc protoporphyrin IX reconstituted myoglobin and performed oxygen quenching experiments at different temperatures. The data was fit to the above model and k$\sp+$ (oxygen entry rate), k$\sp-$ (oxygen exit rate), and $\chi$ (oxygen migration rate) in …
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Encapsulation of iron(III) protoporphyrin IX and tetraphenylporphyrin in metal-organic frameworks for application as heterogeneous oxidation catalysts
… as potential hosts to encapsulate Fe(III) protoporphyrin IX (ferrihaem = Fe(III)PPIX) and Fe(III) tetraphenylporphyrin (Fe(III)TPP). Methyl orange (MO) adsorption was used as an initial model for substrate uptake in MOFs 1 and 2. MOF 1 showed good adsorption of MO (10.3 ± 0.8 mg.g-1 ) which …
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Investigation of an atypical protoporphyric family in South Africa
… with photosensitivity and raised red cell protoporphyrin concentrations, indicative of protoporphyria. Further examination of this family revealed features that were atypical of erythropoietic protoporphyria. These included a highly penetrant disease, disease severity as expressed by more …
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Studies on the Biosynthesis of Protochlorophyllide Ester in Etiolated and Green Tissues of Higher Plants
… which had the spectroscopic properties of Mg-protoporphyrin monomethyl ether (MPE) but physical properties similar to those of protochlorophyllide (Pchlide) ester. When this compound was subjected to demetallation and acid hydrolysis the resulting porphyrin had the chromatographic and spectral …
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The Effects of Physical Training on The Iron Status of Female Athletes
… over either year. Changes in free erythrocyte protoporphyrin (measured in the second season only) did not differ significantly between the two groups.
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Characterization of a Bromoperoxidase From the Marine Algae Penicillus Capitatus
… showed that the prosthetic group is ferric protoporphyrin IX and that the enzyme consists of two equal molecular weight subunits whose combined weight is approximately 100,000. Bromoperoxidase contains no detectable level of carbohydrate.
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The Utilization of Metalloporphyrins as Mechanistic Probes of the Active Site of Heme Proteins
Iron protoporphyrin-IX is a ubiquitous active site in biological systems. It provides the redox couple for electron transport, facilitates the insertion of an oxygen atom into an organic substrate, and also serves as the binding site for dioxygen in O$\sb2$ transport/storage hemoproteins. In the …
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Apoptosis and porphyrin biosynthesis by a photodynamic chemotherapeutic
… (ALA) causes transformed cells to accumulate protoporphyrin IX (Proto). Subsequent exposure to light in vitro causes intracellular Proto to initiate formation of singlet oxygen molecules, leading to self-destruction. This photo-activated destruction by ALA is enhanced by addition of the …
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Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
… and π-stacking interactions with ferriprotoporphyrin IX (Fe(III)PPIX) using a fragment approach was undertaken in order to propose and synthesise novel compounds which followed a hypothesised mechanism of action to inhibit β-haematin formation. Coordination of a series of pyridines, …
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Characterisation of the flavin adenine dinucleotide binding region in Myxococcus xanthus protoporphyrinogen oxidase
This dissertation focuses on protoporphyrinogen oxidase (PPOX), the penultimate enzyme in the haem biosynthetic pathway. Partial defects in PPOX result in variegate porphyria, an autosomal dominant disorder. PPOX catalyzes the six electron oxidation of protoporphyrinogen IX to protoporphyrin IX, in …
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Studies on the degradation of haemoglobin
… succeeded in synthesizing bile pigments and protoporphyrin. He thereby demonstrated the fundamental tetrapyrrolic structure which is common to both haem and bilirubin. Prior to this, in vivo experiments on dogs performed by Mann, Sheard, Bollman and Blades showed that haemoglobin, injected …
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Newly Discovered Intermediates in the Chlorophyll a Biosynthetic Pathway
… a, divinyl chlorophyll a and monovinyl Mg-protoporphyrin-6-ester. Well-established chemical derivatization techniques coupled to absorption and fluorescence spectroscopy were used to identify the pigments. The spectra of the derivatized compounds exhibited the expected spectral shifts and …
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The Development of Peptide Analogues as Potential Fluorescent and PET Imaging Probes.
… to fluoresce and to coordinate metals. A gallium-protoporphyrin IX(PPIX)-ghrelin based analogue was designed as a potential dual PET/fluorescence imaging probe for detection of growth hormone secretagogue receptor 1a (GHS-R1a) and it was found that fluorescence was not quenched upon coordination …
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Soil ingestion and lead concentration in wildlife species
… Idaho were analyzed for free erythrocyte protoporphyrin, fecal, liver, and kidney Pb concentrations, and soil/sediment ingestion. Sediment from the area contained 4485 ppm Pb (d.w.). Protoporphyrin was a poor indicator of Pb contamination at this level of exposure and/or under these …
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LS301 Fluorescence-guided Photodynamic Therapy of brain cancer using PpIX photosensitizer
… deficit, disease recurrence and high mortality. Protoporphyrin IX (PpIX) accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a photosensitizer for photodynamic therapy (PDT). However, the accurate …
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Enzymatic activation of cytochrome P-450(cam)
… which are partially saturated analogues of protoporphyrin IX, were substituted for the native heme in cytochrome P-450$\sb{\rm cam}$ and also rat liver cytochrome $b\sb5$, which served as a useful model for the more difficult reconstitution and subsequent characterization of the P-450 …
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