Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"proton-pump-inhibitor"”.
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Digesting the role of the gut microbiome in proton pump inhibitor (PPI)-induced hypomagnesemia
Contains fulltext : 233371 .pdf (Publisher’s version ) (Open Access)
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Novel mechanism of gastric proton pump inhibitor (PPI) : Suppression of Helicobacter-pylori induced angiogenesis and selective induction of apoptosis in gastric cancer cells.
… a lower extracellular pH, ability to up-regulate proton extrusion is critical for cancer cell survival. Gastric H+/K+-ATPase exchanges luminal K+ for cytoplasmic H+ and is the enzyme primarily responsible for gastric acidification. On the basis of the fact that blocking the clearance of acidic …
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Do proton pump inhibitors reduce the incidence of pharyngocutaneous fistulae following total laryngectomy?
… laryngectomy. We hypothesised that perioperative proton pump inhibitor (PPI) treatment could reduce the incidence of pharyngocutaneous fistulae. This prospective placebo-controlled double-blind randomised controlled trial compared PPI treatment (14 days enteral omeprazole) with a placebo in …
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Evaluation of new diagnostic and treatment strategies in the management of the Zollinger-Ellison syndrome
… and (iv) assess the efficacy and safety of a new proton pump inhibitor (pantoprazole) in controlling acid hypersecretion.
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The Discovery and Development of Thienopyrimidines as Inhibitors of Helicobacter pylori
… 75%. The triple therapy, which consists of a proton pump inhibitor and two broad-spectrum antibiotics such as clarithromycin and amoxicillin, is becoming less effective due to the rise of strains with resistance against these antibiotics. In the search for narrow spectrum drugs for the …
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Pharmacometrics to characterize pharmacokinetics and optimize treatment in understudied populations
… enalapril, an angiotensin-converting enzyme inhibitor for hypertension and heart failure, in a small cohort of African heart failure patients, and characterizing pharmacokinetics of esomeprazole, a proton pump inhibitor for hyperacidity and being investigated for preeclampsia, in patients …
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EVALUATING THE CHEMOTHERAPEUTIC EFFECTS OF SR9009 AND ESOMEPRAZOLE ON ORAL SQUAMOUS CELL CARCINOMA USING CIRCADIAN-TAILORED INNOVATIVE THERAPEUTIC APPROACHES
… clock regulating drug, and/or Esomeprazole, a proton pump inhibitor in HPV- (FaDu) and HPV+ (2A3) OSCC cell lines. To study the extent of disruption of circadian clock gene expression levels after Esomeprazole administration, we analysed the expression of clock genes, BMAL1 and REV-ERBα by …
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Population pharmacokinetic modelling for dose optimization of esomeprazole to treat early-onset preeclampsia
Rationale Esomeprazole is a proton pump inhibitor with preclinical efficacy data showing it lowers concentrations of soluble fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng), pathognomonic biomarkers identified in preeclampsia. A randomized controlled trial, Preeclampsia Intervention …
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Assessment of the autonomic nervous system through the study of cardiovascular autonomic reflexes and their association with inflammation in three clinical settings.
… repeated following 8 weeks of treatment with a proton-pump inhibitor (PPI). Initial reflux symptoms and response to PPI treatment were assessed using the GERD Impact Scale questionnaire. All participants had effective symptom response to treatment and there was no significant difference …
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Verordnung von Protonenpumpenhemmern in der hausärztlichen Praxis
AUSGANGSPUNKT: Trotz der Möglichkeit der Verwendung rationaler und kostengünstiger Alternativpräparate stieg die Verordnungshäufigkeit der PPI seit 1991 stark an. Durch die Studie sollten mögliche Gründe der Hausärzte für eine Verordnung von PPI herausgefunden werden.ZIEL: Die vorliegende Studie …