Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"proton-pump inhibitors"”.
-
Do proton pump inhibitors reduce the incidence of pharyngocutaneous fistulae following total laryngectomy?
… laryngectomy. We hypothesised that perioperative proton pump inhibitor (PPI) treatment could reduce the incidence of pharyngocutaneous fistulae. This prospective placebo-controlled double-blind randomised controlled trial compared PPI treatment (14 days enteral omeprazole) with a placebo in …
-
Utilization of Proton Pump Inhibitors in Combination Regimen for Breast Cancer Treatment by Targeting Fatty Acid Synthase
… (NHEJ) repair of DNA double-strand break. Proton pump inhibitors (PPIs), were originally designed to decrease gastric acid production by binding irreversibly with gastric hydrogen potassium ATPase. PPIs have recently been reported to reduce drug resistance in cancer cells when used in …
-
Protonų siurblio inhibitorių suvartojimo tyrimas Lietuvoje 2022 metais /
… thesis topic: Research on the Consumption of Proton Pump Inhibitors in Lithuania in 2022. The aim of the research: Based on electronic prescriptions issued in 2022, to analyze the trends in the use of proton pump inhibitors in Lithuania according to age, indications and municipalities. Tasks …
-
Epidemiological investigations of liver cancer: biomarkers, reproductive factors and modifiable risk factors:
… by serum ferritin or serum iron. <br/><br/>Proton pump inhibitors and histamine-2 receptor antagonists are commonly used. Proton pump inhibitors have been shown to promote liver cancer in rats; however, only one study has examined the association in humans. We conducted the first study on …
-
Genomics research and cultivating serendipity in pharmaceutical drug discovery : assessing the competitiveness of R&D productivity between the West and Asia
… drugs on the market, ranging from statins to proton-pump inhibitors (PPIs).
-
Probiotic Use in Trauma Patients: A Pathway to Determining the Standard of Care to Improve Outcomes
… These include treatment with antibiotics, proton pump inhibitors, and opioids as well as therapies that require invasive procedures and monitoring. One suggested means to restore immune function and for the prevention of HAIs is to supplement patients with probiotics to restore or replenish …
-
Novel mechanism of gastric proton pump inhibitor (PPI) : Suppression of Helicobacter-pylori induced angiogenesis and selective induction of apoptosis in gastric cancer cells.
… a lower extracellular pH, ability to up-regulate proton extrusion is critical for cancer cell survival. Gastric H+/K+-ATPase exchanges luminal K+ for cytoplasmic H+ and is the enzyme primarily responsible for gastric acidification. On the basis of the fact that blocking the clearance of acidic …
-
Pharmacokinetics and Safety of Acetaminophen in Adult Horses
… NSAIDs, even when those drugs were coupled with proton-pump inhibitors to reduce gastrointestinal side effects; due to cost considerations and the occurrence of adverse side effects from those drugs. In horses, acetaminophen has been reported to be efficacious as an adjunct treatment for …
-
Posterior Laryngitis- Aetiology,Treatment and Health-Related Quality of Life
… investigated for reflux, were treated with proton pump inhibitors. Of the patients not investigated for reflux, 85% received acid-suppressing treatment. One-third of the investigated patients in paper II had objectively measured reflux. Patients with typical reflux symptoms had abnormal …
-
Chloroquine accumulation in Plasmodium falciparum isolated digestive vacuoles
… first direct evidence to suggest this. Vacuolar proton pump inhibitors, proton gradient dissipaters, P-glycoprotein ATPase- and drug transport-inhibitors, weak bases, and structural analogues of chloroquine were used to examine the driving force of chloroquine accumulation in the isolated food …
-
Medications, sex hormones and reproductive factors in relation to gastro-oesophageal cancer risk and survival
… of gastro-oesophageal cancer in patients using proton pump inhibitors and/or histamine-2 receptor antagonists but, particularly for gastric cancer, these associations appeared consistent with confounding by indications rather than a real causal association.<br/><br/>The apparent sex-disparities …
-
Genetic and non-genetic determinants of drug response in type 2 diabetes
… drugssuch as tricyclic antidepressants, proton pump inhibitors and codeine increasedthe odds of GI intolerance. Moreover we showed association of the G allele atrs3889348-<i>SLC29A4</i> (PMAT) withincreased odds of intolerance. In theGoDARTS study performed on subjects who have been …
-
Comparitive activities and mechanisms of action of three novel antiulcer agents
Antiulcer agents, notably inhibitors of gastric acid secretion, have been the most successful category of drugs to be discovered in recent years; and moreover, there are currently four such agents in the world list of top 25 best selling drugs. Histamine H2 antagonists have been the number one …
-
Exploring Gastro-oesophageal Reflux in Infants and Children
… GORD) is characterised. • H2 antagonists and proton pump inhibitors are effective treatments for reflux oesophagitis in children (in terms of symptom relief, improvements of pH/impedance metrics, and oesophageal healing on endoscopy. • There is evidence of an absence of effect for Domperidone, …
-
Deprescribing Unnecessary Pantoprazole Prescribed by Hospitalists on Parkland Hospital Non-ICU Inpatient Floors
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
Laparoskopische Antirefluxchirurgie : Langzeitergebnisse mit dem Tailored Concept
… Therapieregime der GERD ist nach Einführung der Protonenpumpeninhibitoren stärker medikamentös orientiert. Die Entscheidung zu einer operativen Therapie fällt bei progredientem Verlauf, nicht-säureassoziierten Symptomen und als Alternative bei Kontraindikationen zur medikamentösen Therapie. …