Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 71 for “"proton therapy"”.
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Range Adaptive Proton Therapy For Prostate Cancer
Purpose: The rapid distal falloff of a proton beam allows for sparing of normal tissues distal to the target. However proton beams that aim directly towards critical structures are avoided due to concerns of range uncertainties, such as CT number conversion and anatomy variations. We propose to …
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Determination of energy spectra of proton therapy beams
… for measuring the energy spectra of high-energy proton therapy beams in situ under conditions similar to those used for radiotherapy at the South African National Accelerator Centre. The method is based on proton elastic scattering, H(p,p)H, in a thin polyethylene radiator and uses two ΔE-E …
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Incorporating range uncertainty into proton therapy treatment planning
… addresses the issue of robustness in proton therapy treatment planning for cancer treatment. Proton therapy is considered to be advantageous in treating most childhood cancers and certain adult cancers, including those of the skull base, spine and head and neck. Protons, unlike X-rays, …
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Imaging Techniques for Proton Range Determination in Proton Therapy
<p>Proton therapy can achieve better sparing of normal tissues than the conventional photon radiation therapy due to proton’s Bragg Peak property. However, to unlock the full potential of protons, accurate prediction of in vivo proton stopping power ratio (SPR) is required for proton therapy …
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Use of Positron Emission to mography For Proton Therapy Verification
… response monitoring, has recently been used for proton therapy verification. By imaging tissue activation following proton treatment, attempts have been made to verify proton <em>dose</em> and <em>range</em>. In this dissertation, two novel approaches were developed and tested for the purpose of …
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Dual Energy Computed to mography For Proton Therapy Treatment Planning
<p>Proton radiation therapy is gaining popularity because of the unique characteristics of its dose distribution, e.g., high dose-gradient at the distal end of the percentage-depth-dose curve (known as the Bragg peak). The high dose-gradient offers the possibility of delivering high dose to the …
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Monte Carlo simulation of neutron shielding for proton therapy facilities
… Carlo method of modeling neutron shielding of proton therapy facilities in a complex, realistic environment. The bulk neutron shielding of the Northeast Proton Therapy Center (Massachusetts General Hospital, Boston, MA) was used as the basis of the design work. A geometrical model of the …
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Image-Guided Proton Therapy For Online Dose-Evaluation and Adaptive Planning
<p>The main advantage for using protons in radiotherapy is their finite range in patients, allowing for potential improved sparing of normal tissues. However, this comes at a cost of increased sensitivity to range uncertainties. Density changes along the beam path will affect the proton range and …
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Pencil beam dose calculation for proton therapy on graphics processing units
Radiotherapy delivered using scanned beams of protons enables greater conformity between the dose distribution and the tumour than conventional radiotherapy using X rays. However, the dose distributions are more sensitive to changes in patient anatomy, and tend to deteriorate in the presence of …
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Implementation of An Anthropomorphic Phantom For The Evaluation of Proton Therapy Treatment Procedures
… an increasing number of institutions offering proton therapy, the number of multi-institutional clinical trials involving proton therapy will also increase in the coming years. The Radiological Physics Center monitors sites involved in clinical trials through the use of site visits and remote …
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A new prompt gamma spectroscopy-based approach for range verification in proton therapy
Proton therapy is a well-established technology in radiotherapy, whose benefits stem from both physical and biological properties. Ions deposit the maximum dose, i.e. the ratio between the energy absorbed by the tissue and its mass (Gy = J/k g), in a localized region close to the end of their range …
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Intensity Modulated Proton Therapy Optimization Under Uncertainty: Field Misalignment and Internal Organ Motion
Intensity modulated proton therapy (IMPT) is one of the most advanced forms of radiation therapy, which can deliver a highly conformal dose to the tumor while sparing the dose in healthy tissues. Compared to conventional photon-based radiation therapy, IMPT is more flexible in delivering radiation …
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Assessment of and improvements to a stereophotogrammetric patient positioning system for proton therapy
… immobilise and position patients for precision proton radiotherapy. The precision achieved using the stereophotogrammetric (SPG) positioning system is measured, and the shortcomings and errors in using the facemask by the SPG system are measured and analysed. The implementation of improvements …
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Dual energy image reconstruction and systems for application in proton therapy treatment planning
Proton therapy is the use of a proton beam rather than a traditional X-ray beam in the treatment of cancer. This technique is being developed all over the world due to the unique Bragg peak feature of proton beams. In order to guarantee accurate dose delivery to the tumour, the stopping power ratio …
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Assessment of the use of prompt gamma emission for proton therapy range verification
PURPOSE: Prompt gamma rays emitted from proton-nucleus interactions in tissue present a promising non-invasive, in situ means of monitoring proton beam based radiotherapy. This study investigates the fluence and energy distribution of prompt gamma rays emitted during proton irradiation of phantoms. …
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Robust Treatment Planning and Robustness Evaluation for Proton Therapy of Head and Neck Cancer
Intensity modulated proton therapy (IMPT) in head and neck squamous cell carcinoma (HNSCC) offers superior advantages over conventional photon therapy, by generating high conformal doses to the target volume and improved sparing of the organ at risks (OARs). Besides, robust treatment planning …
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The development of a real-time photogrammetric system for patient positioning in proton therapy
… for the positioning of patients undergoing proton therapy. The positioning of patients involves moving their tumours into a horizontal proton beam. In the past, patients have been mechanically positioned and restrained. However, with the development of this new "StereoPhotoGrammetric" (SPG) …
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Evaluation of Radiobiological Effects in Intensity Modulated Proton Therapy : New Strategies for Inverse Treatment Planning
… treatment planning for intensity modulated proton therapy (IMPT) usually disregards variations of the relative biological effectiveness (RBE). To investigate the potential clinical relevance of a variable RBE for beam scanning techniques, new strategies for the evaluation of radiobiological …
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