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Showing 1 to 9 of 9 for “"proton sponge"”.
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Bis(dialkylamino)cyclopropeneimine Substituted Proton Sponge Derivatives: Synthesis, Theory, and Application
… containing compounds, mostly within the proton sponge backbone. The properties of these molecules are discussed in the context of other proton sponge derivatives reported in the literature. The superbasicity, catalytic activity, and fluorescent nature of these cyclopropenimine derivatives …
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Development and Investigation of the Fluorescence of Cyclopropenium Ions
… compounds. A novel guanidine-cyclopropenimine proton sponge with exceptional basicity is reported that was further utilized to develop a stable tetracoordinate boronium-substituted proton sponge. A large focus of this thesis was also placed on the development of the recently discovered …
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pH-sensitive core-shell nanoparticles for intracellular drug delivery
… pH-responsive core that would absorb protons at endolysosomal pH, and a shell whose composition could be tuned to facilitate particle targeting, cell binding, and drug binding. Two-stage surfactant-free emulsion polymerization of 2-diethylamino ethyl methacrylate (DEAEMA) (core) and …
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Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles
… different cell lines in a nontoxic manner. The "proton sponge hypothesis" has attempted to relate the buffering capacity to endosomal release of polyethylenimine (PEI) based polyplexes, which could contribute to high transfection efficiency. Secondary amine structures rendered PGAAs buffering …
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Synthesis and Characterization of Nucleobase-Containing Polyelectrolytes for Gene Delivery
… formed with these systems according to the proton-sponge hypothesis. One method of reducing the overall cationic character for these systems is incorporation of non-electrostatic binding mechanisms such as hydrogen bonding. A series of nucleobase-containing PDMAEMA copolymers were utilized …
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Block Copolymer Formation by Transformation Reactions
… by performing the reaction in the presence of a proton sponge.
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Investigation of barriers to non-viral gene delivery and design of novel polymer-based gene delivery systems
… providing quantitative validation of the proton sponge hypothesis. By studying the gene transfer properties of a library of polymeric vectors, we were able to elucidate new vector structure-function relationships. We also investigated the combined impact of non-structural factors-such as …
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Transition Metal Complexes of 3,7-Diazabicyclo[3.3.1]nonane Derivatives : Complex Stabilities and Oxidation Reactivity of Cobalt (II) and Vanadium (IV)
… Arten von Bispidinliganden bestimmt, wobei der “proton sponge“ Effekt beobachtet werden konnte. Der erste logKs-Wert aller Liganden wurde im Bereich 11,2 bis 12,2 gefunden. Die Liganden können in zwei Gruppen eingeteilt werden. Zur ersten Gruppe gehören N2Py2, N2Py3, N2Py3u und 6Me-N2Py2, welche …
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Chirale Sulfonimidamide und Sulfoximine : Synthese, Strukturuntersuchungen und Anwendungen
… shows structural similarities to so-called proton sponges. Protonation experiments towards the determination of the basicity were carried out and the kinetic activity of the bissulfoximine was determined in a proton self-exchange reaction. A discussion of the structures of the free base and …