Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"proton leak"”.
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Systems biology approach to understanding the control of glucose metabolism in healthy and apoptotic neurons
… coupled with direct activation of mitochondrial proton leak resulted in the neurons becoming more reliant on glycolytic ATP. Direct stimulation of the pentose phosphate pathway as well as proton leak could be consequences of increased oxidative stress that is commonly associated with apoptosis. …
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Structure and regulatory mechanism of human uncoupling protein 1
… is activated by free fatty acids and catalyses proton leak, dissipating the proton motive force, which mitochondria use to drive ATP synthesis. Therefore, UCP1 uncouples the oxidation of nutrients from the phosphorylation of ADP, releasing heat instead of generating ATP. The thermogenic …
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Nitrite and insulin lower the oxygen cost of ATP synthesis in skeletal muscle cells by pleiotropic stimulation of glycolysis
… oxygen consumption linked to mitochondrial proton leak, thus increasing mitochondrial efficiency. Nitrite does not improve coupling efficiency in myoblasts or myotubes. Further investigations revealed that stimulation of glycolytic ATP supply is not secondary to increased glucose …
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Effects of Trimethylamine N-Oxide on Mouse Embryonic Stem Cell Properties
… Additionally, TMAO resulted in increased proton leak, indicating increased oxidative stress, and elucidating a potential underlying mechanism for TMAO-induced loss in mESC stemness. Altogether, these findings indicate that TMAO decreases stem cell potency potentially via modulation of …
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The Effect of Alhagi maurorum Medik on Mitochondrial Function
… including, basal respiration, ATP production, proton leak, spare respiratory capacity, maximal respiration, and non-mitochondrial respiration. In the cells treated with hordenine, the key bioactive compound of Alhagi maurorum, results indicate that hordenine has no significant effect on MCF-7 …
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STUDY ON HISTONE DEACETYLASE 3 AND ITS PHARMACOLOGICAL REGULATION IN THE PATHOPHYSIOLOGY OF ADIPOSE TISSUE
… (i.e., basal respiration, ATP production, proton leak, maximal respiration, spare respiratory capacity and non-mitochondrial oxygen consumption). Conclusions: The early epigenetic events mediated by HDAC3 silencing are crucial to commit adipocyte precursors towards a metabolic phenotype …
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Characterisation of the molecular mechanisms of dopaminergic axonal growth and their impairment in Parkinson's disease
… NME1 treatment increases maximal respiration and proton leak in SH-SY5Y cells which confirmed that NME1 regulates mitochondrial respiration and promotes neurite growth. In Chapter 5, we explore the immediate effectors of GDF5 on neuronal cells using a proteomics approach. Our proteomics screen …