Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"protocells"”.
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Coacervate protocells as reaction centres at the origin of life
Contains fulltext : 325221.pdf (Publisher’s version ) (Closed access)
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Design and Characterisation of a Novel Artificial Life System Incorporating Hierarchical Selection
… to exist within externally provided containers - protocells. This research is focused on the period of time surrounding the conjectured first Major Transition - from individual replicating molecules to populations of molecules existing within cells. Protocells can be thought of as simplified …
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The behaviour of fatty acid vesicles in prebiotically plausible environments
… of model protocell systems, the study of model protocells assembled from fatty acid vesicles is lacking in comparison to the abundant literature on phospholipid vesicles. There is evidence that the existence of fatty acids predated life on Earth. Moreover, the highly dynamic nature of fatty acid …
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Development of novel bio/nano interfaces for materials science and biomedical applications
… (protocell') for targeted delivery applications. Protocells combine enhanced specificity, stability, and cargo capacity when compared to similarly-sized liposomes. They can, additionally encapsulate and deliver multicomponent cargos. Due to their unique biophysical features, protocells loaded with …
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Chemically driven soft bioinspired systems and the variational formulation of physics-informed neural networks
… the gel diffusiophoresis. Second, we investigate protocells — giant unilamellar lipid vesicles that preceded the first unicellular organisms. We analyze the spontaneous formation of subcompartments within these protocells. Using a continuum elastohydrodynamic theory, we demonstrate how attractive …
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Lateral Transfer of DNA in Protocell-like Synthetic Cells
… horizontal movement of genetic material among protocells. Additionally, this work highlights key experimental challenges in modeling prebiotic genetic exchange, while also contributing to the development of synthetic biological systems that emulate early evolutionary processes.
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Engineering artificial cell membranes by Ting F. Zhu.
… origin of cellular life is how primitive cells (protocells) lacking complex biological machinery could grow and divide. To address this question, we first developed an effective method for preparing large monodisperse (uniform-sized) vesicles through a combination of extrusion and large-pore …
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Programmable Assembly of Elastin-like Polypeptides Within Droplet Microenvironments
… regulate gene expression within droplet-based protocells. Taken together, this body of work offers new insights into (1) our understanding of the genetic to molecular to macroscale relationships encoding naturally occurring intrinsically disordered protein assemblies, (2) the design rules of …
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RNA-Peptide Based Coacervates as a Prebiotically Plausible Pathway towards a Proto-Ribosome
… planet. A key goal in this is understanding how protocells formed in an abiotic environment as a pathway to the first biotic cells. A challenge presented in the emergence of cells is the existence of the ribosome, the cellular machine which translates RNA into peptides and proteins. While found …
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Study of porous magnetic nanocomposites for bio-catalysis and drug delivery
… silica-magnetite core-shell nanoparticles (protocells) and polymer capped mesoporous silica-magnetite core-shell nanoparticles. The drug loading and release profiles of the developed nanomaterials were assessed using two different anticancer drugs; Mitomycin C (MMC) and Doxorubicin (DOX). …