Global ETD Search
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Showing 1 to 3 of 3 for “"protocadherin 15"”.
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The Nanomechanics of Protocadherin 15, A Protein Essential for Human Hearing
… comprises four protein molecules: a dimer of protocadherin 15 and a dimer of cadherin 23, both of which are stabilized by Ca<sup>2+</sup> binding. Further underscoring the role of the tip link in hearing, there are numerous mutations of its constituent proteins that result in deafness. My …
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Modeling human Usher syndrome during Drosophila melanogaster development
… properties. Similar to its human ortholog Protocadherin 15, Drosophila Cad99C localizes to microvillar protrusions in the follicular epithelium. In this epithelium, Cad99C is required for the proper morphogenesis and organization of microvilli into bundles, similar to human Protocadherin …
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Tension Propagation Along Tip-Link Cadherins: Regulation and Implications for the Auditory System
… A tip link comprises a heterotetremer of protocadherin-15 and cadherin-23, arranged in a loose helical configuration and joined at their amino-terminals through a calcium ion dependent interaction. As for many other biopolymers, the tip link's stiffness is several times greater than that …