Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"proto-oncogene"”.
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Translational Regulation of the C-Jun Proto-Oncogene
<p>The <em>v-jun</em> oncogene was originally isolated from the ASV17 virus in 1987. Ever since its isolation, extensive work has been done to understand the role of the v-jun oncogene in cell transformation. The c-Jun protein is a transcription factor which binds to the DNA target TGACTCA. The …
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Proto-oncogene Regulation by Growth Factors in Bone Cells
… the molecular level, the expression of several proto-oncogenes was studied. IGF-I and IGF-II cause a rapid and transient induction of c-fos in MC3T3-E1 cells similar to that observed with other growth factors in other cell types. TGF-beta causes a similar rapid induction of c-fos which is …
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Distinguishing the Role of the c-myb Proto-Oncogene in Mouse Models of Cardiovascular Disease
Despite considerable advances in our understanding of disease processes, cardiovascular diseases remain the top cause of mortality and morbidity in society today. Investigating the molecular and cellular mechanisms involved in the pathogenesis of these diseases to discover new therapeutic targets …
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Mechanisms of 17-beta-estradiol regulation of the proto-oncogene Bcl-2 in MCF-7 human breast cancer cells.
In the present studies, the mechanisms of estrogen regulation of Bcl-2 were investigated by analyzing the expression of different Bcl-2 promoter-driven constructs stably transfected into MCF-7 cells. An approximately 1.7 kilobase (kb) sequence which directed estrogen-dependent regulation of Bcl-2 …
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Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia
Overexpression of proto-oncogene c-jun and constitutive activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process. However, c-jun expression has not been investigated in acute myeloid leukemia (AML) cells containing the most common …
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ΜΕΤΑΛΛΑΞΟΓΕΝΕΣΗ ΚΑΙ ΕΝΕΡΓΟΠΟΙΗΣΗ ΤΟΥ RAS ΟΓΚΟΓΟΝΙΔΙΟΥ ΑΠΟ ΑΛΚΥΛΙΩΤΙΚΟΥΣ ΚΑΡΚΙΝΟΓΟΝΟΥΣ ΠΑΡΑΓΟΝΤΕΣ
… INTOTHE CODONS 12 AND 13 OF THE HUMAN HA-RAS1 PROTO-ONCOGENE. THE 06MEG MUTAGENESIS WAS STUDIED IN E. COLI CELLS OF DIFFERENT REPAIR CAPACITIES: 1) O6MEG INDUCEDEXCLUSIVELY G-> A MUTATIONS, 2) THE MECHANISM OF THE METHYL- DIRECTED MISMATCHREPAIR PROTECTS, INDIRECTLY THE E. COLI CELL FROM THE …
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Determination of the Feasibility of Using Cell-Free DNA (cfDNA) in the Q-Clamp KRAS Codon Specific Mutation Test
<p>KRAS is a proto-oncogene which was first identified in Kirsten rat sarcoma virus. The normal KRAS protein performs an essential function in normal tissue signaling and a mutation of a KRAS gene is an essential step in the development of many cancers. Q-Clamp® KRAS codon specific mutation test is …
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Thewingless Signaling Pathway Specifies Fates in the Drosophila Embryonic CNS
The secreted proto-oncogene Wnt-1/Wingless (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the …
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The wingless signaling pathway specifies fates in the Drosophila embryonic CNS
The secreted proto-oncogene Wnt-1/Wingless (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the …
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Competition Between Grb2 and Plcγ1 For Binding to Fgfr2 Regulates Phospholipase and Pten Activity, Leading to Cell Invasion and Proliferation
… of Grb2 indirectly leads to activation of the proto-oncogene Akt inducing phenotypic alterations characteristic of tumorigenesis including anchorage-independent cell growth and tumor formation in mice models.</p>
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Pressure-Induced Intracellular Signaling in Isolated Arteries
… C. In contrast, the expression of the proto-oncogene, c-fos, in response to pathological increases in intraluminal pressure is regulated by tyrosine kinase pathways.</p>
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Unbiased global proteomic profiling of patient-derived meningiomas of all grades to identify molecular signatures of differentially expressed proteins and phosphoproteins.
… overexpressed in all grades were the nuclear proto-oncogene SET and the splicing factor SF2/ASF, while another newly identified protein that was specific for high-grade meningiomas was the glycolytic enzyme hexokinase-2, involved in cellular metabolism. In summary, we generated a proteomic …
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Targeted 177 Lu antisense radiotherapy of B-cell non-Hodgkin's lymphoma
… REQUEST.] The B-cell lymphoma/leukemia-2 (bcl-2) proto-oncogene in non-Hodgkin's lymphoma (NHL) is a dominant inhibitor of apoptosis. The research goal was to develop a [superscript 177]Lu-labeled bcl-2 antisense peptide nucleic acid (PNA)-peptide conjugate designed for dual modality NHL therapy, …
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Quantitative analysis of the effect of leflunomide on neural crest cell gene regulation during early embryonic development
… genes involved in neural crest specification the proto-oncogene cMyc and cMyc responsive genes are affected. cMyc is implicated in embryonic stem cell transcriptional elongation and is well characterised to play an important role in neural crest specification.
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The SYK tyrosine kinase suppresses autolysosome biogenesis via activation of mTORC1 in pancreatic cancer cell lines
… in a number of diverse cell types. KRAS is a proto-oncogene that controls cell growth and proliferation through several mitogenic pathways. In pancreatic cancer, KRAS is frequently mutated, resulting in constitutive activation in 90% of pancreatic cancer cell lines. We previously showed that …
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Effects of Long-Term Exposure of Normal C57BL/6J Inbred Mice to 17β-Estradiol on Gene Expression in Lymphocytes: mRNA Analysis of Lymphokines and bcl-2/fas
… to 17β-estradiol on lymphokine and bcl-2/fas (proto-oncogenes) mRNA expression. We evaluated the effects of estrogen on the expression of genes for lymphokines, which are essential for the immune response. It is hypothesized that estrogen may regulate the immune system by modifying the …
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Novel Functions of the Transcription Factor Aryl Hydrocarbon Receptor (AHR) and Its Tryptophan-Derived Ligands in Cancer Cells
… reprogramming of cancer cells, focusing on the proto-oncogene MYC and the aryl hydrocarbon receptor (AHR). The role of MYC in regulating tryptophan (Trp) metabolism was investigated in colon and liver cancer cells using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). …
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Identification of proteins interacting with the human mismatch repair protein MLH1
… MED1. Amongst the other genes identified was the proto-oncogene c-MYC, a gene previously implicated in genetic instability and apoptosis. Using in vitro derived mutants of c-MYC, it has been shown that hMLH1 interacts with the leucine-zipper domain of c-MYC. The effect of elevated c-MYC expression …
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Dissecting the function and targets of FOXG1 in glioblastoma
… (two forkhead family proteins), as well as the proto-oncogene MYCN and key regulators of both DNA and chromatin methylation, including TET3 and CHD3. Pharmacological inhibitors of MYC block FOXG1-driven de-differentiation, whereas Vitamin C and 5-azacytidine – agents that disrupt DNA and …
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Elucidating the Role of BMI1 in Lung and Colon Tumor Maintenance and Progression
… and differentiation, and it is also a proto-oncogene that is overexpressed in a wide variety of cancer types. Given its role in normal stem cell biology and its overexpression in cancer, there is strong interest in inhibiting BMI1 as a method of targeting CSCs. In this thesis, I will …
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