Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"prothrombinase"”.
-
Choline Inhibition of Prothrombinase
… order to quantitate the effects of choline on prothrombinase activity, bovine factor V and human factor II were isolated in this laboratory by established methods, and other prothrombinase components were obtained from commercial sources. The activity of venom-activated bovine factor Xa was …
-
Studies of Coagulation and Fibrinolysis
The mechanism and regulation of prothrombinase function in the activation of prothrombin and prethrombin-1 were studied. In addition, the kinetics of plasmin-mediated fibrin degredation were determined. First, the mechanism of prothrombin activation by prothrombinase was investigated using two …
-
Studies of structure-function relationships in two human coagulation proteins: factor XII and prothrombin
… During activation of prothrombin by the prothrombinase complex (FXa, FVa, phospholipids and Ca++), transient activation intermediates are produced. The intermediate meizothrombin has enzymatic activity but very little coagulant activity while intermediate prethrombin-2 has no enzymatic …
-
Contribution of different types of phospholipids in blood coagulation
… focuses on testing the ABC hypothesis in the prothrombinase complex (the complex of factors Va and Xa, which are responsible for converting prothrombin to thrombin). For fX activation by TF:fVIIa, it was shown that effects of PE and phosphatidylglycerol (PG) are basically similar and that …
-
Inhibiting platelet scramblase activity
… for binding of the tenase (FIXa/VIIIa) and prothrombinase (FXa/Va) complexes that generate a burst of thrombin production responsible for occlusive clot formation. All current anti-platelet drugs are associated with bleeding side effects since they inhibit pro-aggregatory platelet activity. …
-
Characterization of OmpT: An outer membrane vesicle protease Escherichia coli that attenuates blood coagulation.
… generation and fibrin clot formation as part of prothrombinase. The fibrin clot immobolizes the pathogen and allows the immune system to target and destroy the bacterium. Our research has shown that pathogenic Escherichia coli O86a:K61 secretes the protease OmpT as part of outer membrane vesicles …
-
Targeting phosphatidylserine exposure in pro-coagulant platelets.
… charged surface. Assembly of the tenase and prothrombinase complexes enhances their activity, increasing thrombin generation. PS is normally confined to the inner leaflet of the plasma membrane by flippase activity, preventing its exposure on the outer surface of unstimulated and …
-
Blood coagulation reactions on nanoscale membrane surfaces
Blood coagulation requires the assembly of several membrane-bound protein complexes composed of regulatory and catalytic subunits. The biomembranes involved in these reactions not only provide a platform for these procoagulant proteins, but can also affect their function. Increased exposure of …