Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 799 for “"proteomics"”.
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Deep learning of proteomics data
… in sequencing technology have allowed proteomics to mature to the level where deep learning is now a viable option. This thesis will primarily consider the application of deep learning for modelling the various properties of a protein.<br/><br/>Although deep learning addresses some of …
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Bayesian Methods for Spatial Proteomics
… subcellular compartments. To analyse spatial proteomics data, they are first annotated with marker proteins, which are proteins with a priori known unambiguous localisations. Typical analysis proceeds by training a machine learning classifier to assigned proteins with unknown localisations to …
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Proteomics for cancer biomarker discovery
… to knowing which proteins are being produced. Proteomics hold great promise for careful examination of the proteins in complex biologic fluids and tissues, and it may be possible to detect disease from a patient's serum, long before it would otherwise be clinically evident. Although there have …
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Metal-protein interactions for proteomics applications
… been well documented, but their applications in proteomics are underdeveloped. We have been developing and applying metal-protein interaction based approaches for proteomics studies due to their affordability, versatility and tunability. Previously, the Tao lab introduced Polymer-based Metal …
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Toward a microfluidic system for proteomics
… in the application of microfluidic systems to proteomics in recent years. This is because of the many unique advantages afforded by the reduced dimensions of microfluidic systems compared to classical methods. The reduction in the reaction vessel dimensions leads to a high degree of control, …
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Multidimensional liquid chromatographic separations for proteomics
… separation methodology suitable for small-sample proteomics (minimum effective protein load of 200 μg) and good reproducibility (1.5% variation in the ion exchange dimension, 0.5% variation in the reversed phase dimension). Analysis of the digested fractions gave good coverage of the proteome as …
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Proteomics: A close encounter with rheumatology
… te maken van een grootschalige techniek zoals proteomics. Voor deze experimenten werden 30 RA en 30 non-RA serum stalen geïncubeerd ten opzichte van een synoviaal eiwit extract. De autoantilichamen aanwezig in het serum van RA patiënten waren gericht tegen dat de subunits van synoviaal …
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IP Algorithm Applied to Proteomics Data
… recent years as a valuable tool in the study of proteomics. However, the data thus produced exhibits hyper-dimensionality. Reducing the dimensionality of the data often requires the imposition of many assumptions which can be harmful to subsequent analysis. The IP algorithm is a dimension …
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Luminescent Systems for Genomics and Proteomics
… and diagnostic in the fields of biology, proteomics and genomics. Different aspects and problems were investigated, requiring different strategies and approaches. The whole work was thus divided into separate chapters, each based on the study of one specific aspect of luminescence: …
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Database support for top-down proteomics
Top-down proteomics is a revolutionary application for the identification and characterization of protein, known to be one of the most complicated and challenging issues in biology. In top-down proteomics, the quality and speed of the data warehouse is very important, as high accuracy results are …
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3D chromosome structure and chromatin proteomics
The selective interpretation of the genome through transcription enables the production of every cell type's distinct gene expression program from a common genome. Transcription takes place within, and is controlled by, highly organized three-dimensional (3D) chromosome structures. The first part …
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Ovarian cancer serum biomarker discovery using proteomics
Ovarian cancer is a lethal gynaecological malignancy which is known as the silent killer. It has a poor prognosis due to the lack of major symptoms in early stage disease and hence its late detection. Cancer antigen-125, the most widely used biomarker for ovarian cancer detection, lacks appropriate …
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Data mining in computational proteomics and genomics
… mass spectrometry (LC-MS) data used in proteomics research. These data can be modeled as a time series, in which the X-axis represents time points and the Y-axis represents intensity values. A peak occurs in a set of 2D LC-MS data when the sum of the intensity values in a sliding time …
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Proteomics and dynamics of the human nucleolus
The nucleolus is the most prominent structure within the eukaryotic cell nucleus and it was established to be the site where the majority of ribosomal RNAs (5.8S, 18S and 28S) are transcribed, processed and assembled with ribosomal proteins to form ribosomal subunits. The sole role of ribosome …
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Biomarker Discovery in Autoimmune Diseases: A Proteomics Approach
… marker discovery. Mass spectrometry-based proteomics biomarker discovery holds the ability to interrogate a constellation of proteins simultaneously in a high-throughput manner to uncover a panel of markers that are specific to the presence of a disease. However, the rate of introduction of …
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Proteomics Study of Pre-Harvest Sprouting in Wheat
… producers groups. During this investigation, proteomics studies of PHS-resistant and PHS-susceptible wheat embryos were conducted at different imbibition time periods via a cutting-edge technology called iTRAQ. Proteomic analysis revealed that 190 differentially expressed proteins might be …
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Disease biology of mitochondrial complex-I: Proteomics insights
Contains fulltext : 110935.pdf (Publisher’s version ) (Open Access)
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Optimized GeLC-MS/MS for Bottom-Up Proteomics
… and represent a significant bottleneck in proteomics. A method was developed for rapid validation of borderline hits, which takes advantage of the independent interpretation of the acquired tandem mass spectra by de novo sequencing software PepNovo followed by mass-spectrometry driven BLAST …
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