Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 517 for “"proteome"”.
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Proteome-Wide Prediction of Acetylation Substrates
<p>Eukaryotic DNA is found packaged with proteins and RNA, which forms a substance called chromatin. This packaging is dynamic and regulates access to DNA for essential cellular processes such as transcription, replication, and repair. In recent years, studies have shown that regulated changes in …
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Circadian Orchestration of the Cellular Proteome
… to characterise the cellular circadian proteome, and I uncovered the reciprocal, rhythmic regulation of protein and ion concentrations in cultured cells. Strikingly, by using a genetic knock-out of the CRYPTOCHROME (CRY) proteins I found that the generation of these rhythms was not …
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Multiscale dissection of bacterial proteome optimization
The quantitative composition of proteomes results from biophysical and biochemical selective pressures acting under system-level resource allocation constraints. The nature and strength of these evolutionary driving forces remain obscure. Through the development of analytical tools and precision …
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Multidimensional profiling of the Toxoplasma gondii proteome
… state-of-the-art proteomics methods to study the proteome of the model apicomplexan T. gondii across multiple dimensions: abundance, stability, time, and space. Chapter 2 describes how I employed thermal proteome profiling to identify the target of an antiparasitic compound, thereby enhancing our …
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Homoglutathione Synthetase And The Plant Thiol-Redox Proteome
… Synthetase and the Plant Thiol-Redox Proteome by Ashley Galant Doctor of Philosophy in Biology and Biomedical Science: Plant Biology) Washington University in St. Louis, 2011 Professor Joseph M. Jez, Chairperson In the plant cell, redox regulation and redox responsiveness are governed …
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Proteome-Seq: Sequencing-Based Readout Of Proteomic Analytical Assay
… dynamics and the vast complexity of proteome. While RNA sequencing is a workhorse of high-resolution single-cell analysis, it captures cellular states pre protein translation. Additionally, cell RNA abundance correlates poorly with protein abundance, thus explaining only fraction of …
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Quantitave proteome differences in mitochondria between tissues and diabetes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Deep learning and coevolution reveal proteome-wide protein-protein interactions
… interactions (PPI) within an organism's proteome guides a plethora of potential biological processes at an organism’s disposal. Understanding these PPIs is critical to our understanding of biological systems, however identifying interactions with high accuracy is challenging. Medium to …
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Investigation of the Gracilaria gracilis proteome response to nitrogen limitation
… spectrometry was used to investigate G. gracilis proteome changes in response to nitrogen limitation and recovery. Putative identities of 22 proteins that were changed significantly (P<O.05) in their abundance in response to nitrogen limitation and recovery were obtained. The identified proteins …
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Salivary proteome investigation for Autoimmune Liver Diseases classification and biomarker discovery
… qualitatively and quantitatively the salivary proteome. The present thesis reports the analysis of the salivary proteome from patients affected by AIH and PBC in comparison with healthy controls (HCs) using an integrated top-down/bottom-up proteomic pipeline with the purpose of identifying …
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Proteome Profiling of Saccharomyces cerevisae stress response to Cumene Hydroperoxide (CHP)
Oxidative stress, described as the state of disturbed intracellular redox balance, has been associated with several human conditions including ageing, apoptosis, cancer, autoimmune and neuro-degenerative diseases. Stress studies have shown that reactive oxygen species (ROS) and reactive nitrogen …
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Dynamic proteome profiling of human muscle responses to high-intensity interval training
… are underpinned by changes to the muscle proteome, i.e. relative increases or decreases in the abundance of select proteins. Proteomic analysis of human muscle biopsy samples involves non-targeted analysis of a large number of proteins and can generate new hypotheses. To date, the majority …
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The effect of Retinol Binding Protein on the Proteome of muscle cells.
Vitamin A is essential for normal embryonic development and vision. Retinol binding protein (RBP) and its receptor, STRA6, are vital for the maintenance of intracellular stores of vitamin A. Recently, elevated serum RBP concentration has been implicated as a contributing factor to the development …
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A SYNTHETIC TMRNA PLATFORM FOR ELUCIDATION OF BACTERIAL PROTEOME REMODELING UNDER STRESS
… protein turnover and proteolysis. Total proteome measurements give a view of the stable proteome but can fail to capture dynamic changes under stress, including incomplete polypeptides that result from cleaved mRNAs or stalled translation events. Bacteria employ a nearly ubiquitous native …
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Novel Applications of Top Down MS/MS for Interrogating the Human Proteome
… forms, with ∼12% overlap between the two proteomes. The protein forms were produced by 162 unique genes (∼22% overlap). The above information demonstrates the dynamic expression patterns of proteins in various human cell types. Among the above identifications, 89 proteolysis events, 16 …
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Investigation of ACE-overexpression in Myeloid Cell Lines through Whole-Proteome Analysis
Abstract Angiotensin converting enzyme (ACE) plays an important role in blood pressure regulation and is a key component of the renin-angiotensin aldosterone system (RAAS). A dipeptidyl carboxypeptidase, ACE also hydrolyses many different substrates across its N- and C-domain. This substrate …
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