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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 361 for “"proteolysis"”.
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Adrenergic control of proteolysis in brown adipocytes
… of mitochondrial proteins is due to lysosomal proteolysis or proteolysis within mitochondria, under adrenergic influence. Mouse pre-adipocytes in culture differentiated to brown adipocytes. Increased expression of UCP1 was induced by norepinephrine (NE). NE was then removed and the pattern of …
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Primary proteolysis of caseins in cheddar cheese
Studies were undertaken to investigate proteolysis of the caseins during the initial stages of maturation of Cheddar cheese. Isolated caseins were hydrolyzed by enzymes thought to be of importance during cheese ripening and the resulting peptides isolated and identified. Large peptides were also …
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Proteolysis - induced changes in meat collagen during conditioning.
Changes in intramuscular connective tissue brought about by conditioning were investigated in bovine muscles of different quality. Perimysial and endomysial collagens were solubilized to a small extent during conditioning and residual insoluble collagens in both connective tissue domains were …
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Role of Abberant Proteolysis in the Pathogenesis of APL
Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), is caused by PML-RARN1, a fusion protein resulting from chromosomal translocation involving the promyelocytic leukemia (PML) and the retinoic acid receptor N1 (RARN1) genes. PML-RARN1 promotes misfolding of nuclear …
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Inhibition of Cell Proliferation through Regulated Intramembrane Proteolysis of CREB3L1
… and activated by regulated intramembrane proteolysis in response to stimuli like ER stress. By comparing gene expression between Huh7 subclones that are permissive for hepatitis C virus (HCV) replication versus the non-permissive parental Huh7 cells, we identified CREB3L1 as a host factor …
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Regulated Histone H3 Proteolysis During Mouse Embryonic Stem Cell Differentiation
<p>The association of genomic DNA with histone proteins in the three-dimensional structure known as chromatin is the central framework for "epigenetics," which is defined as inherited phenotypes governed by differences that cannot be explained by changes in DNA sequence. In recent years, studies …
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Influence of Chelating Agents on Proteolysis of Micellar Casein Slurries
… <p>Influence of chelating agents on proteolysis</p> <p>of micellar casein slurries</p> <p>Azucena Becerril Díez</p> <p>The focus of this research was to analyze the effect of Ca chelators on the proteolytic activity of rennet during ripening of a micellar casein slurry. This research …
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Characterisation of fibrinogen and fibrin proteolysis by the neutrophil membrane
… (PMA, 5-10 ng/ml) stimulated neutrophils. This proteolysis is predominantly an extracellular event which occurs through a ligand dependent release of this protease from the neutrophil. Degradation products arising from this proteolysis not only become neutrophil associated but influence a number …
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Proteolysis of zeins in the endosperm of germinating maize seeds
… body core. Based on these observations the proteolysis of the protein in protein bodies of maize would start from the periphery and proceed towards their core. The proteases involved in degradation of various zein components were synthesized de novo. The mRNAs pre-existing in dry seeds …
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Induced Degradation of G-Protein-Coupled Receptors Through Proteolysis Targeting Chimeras
… roles in cancer progression. TPD methods include proteolysis targeting chimeras (PROTACs), which are heterobifunctional molecules where one end has a ligand for the protein-of-interest (POI), and the other end has an E3 ligase recruiting ligand. PROTACs take advantage of the ubiquitin-proteasome …
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Synthesis of Non-Steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (Protacs)
To make the PROTAC design more useful, a small molecule E3 ligase peptide mimic is desirable. The HIF-1alpha E3 ligase destruction sequence utilized in the PROTAC design requires a hydroxylated proline residue for recognition by the VCB E3 ligase. The synthesis of a tetrahydrofuran-based …
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Proteolysis of mammary secretion proteins during involution of bovine mammary gland
In cattle, during the early dry period the mammary gland undergoes a process of involution. The profile of mammary secretion proteins changes throughout the dry period. Increased proteolytic activity and breakdown fragments of milk proteins contribute to the composition of mammary secretions during …
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Cellular Determinants Of AURKA Degradation By Small Molecule Proteolysis-Targeting Chimeras
In recent years the development of proteolysis-targeting chimeras (PROTACs) has enhanced the field of ubiquitin signalling through advancing therapeutic targeted protein degradation (TPD) strategies and generating tools to explore the ubiquitin landscape. However, the cellular factors that modulate …
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Proteolysis targeting chimeras for the directed ubiquitination of the androgen receptor
Proteolysis targeting chimeras (PROTACs) are an emerging field of therapeutics and promising potential drug candidates. PROTACs consist of a target protein binder connected via a linker to an E3 ligase binder. PROTACs hijack the ubiquitin proteasome system to degrade the target protein in a …
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The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity
… memory. More recent studies indicate that proteolysis by the ubiquitin-proteasome pathway (UPP) plays a critical role in long-term synaptic plasticity, and dysregulation of this pathway is associated with cognitive impairments in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, …
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Balancing growth and repulsion: Slit proteolysis generates diverse signals in axon guidance
… the potential conserved function of Slit proteolysis and Slit fragments. We find that the vertebrate homolog of Tok, Tolloid-like1 (TLL1), is a primary protease responsible for SLIT2 cleavage in mice. In vivo, the full-length SLIT2 produced by a SLIT2-UC allele is sufficient to repel DRG …
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USING ANTISENSE MESSENGER RNA TO DOWNREGULATE LON MEDIATED PROTEOLYSIS IN ESCHERICHIA COLI
The advent of metabolic engineering has instigated the introduction of foreign heterologous proteins into host cells, such as Escherichia coli. However, the metabolic burden incurred by the host cell to produce the desired recombinant protein elicits a cellular stress response that can result in …
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Ectodomain Mutations Alter the Proteolysis of the Amyloid-β Precursor Protein (APP)
… formed from Amyloid-β Precursor Protein (APP) proteolysis. APP proteolysis can result in either anti-trophic or trophic peptides. Several APP polymorphisms exist that cause or protect against AD by altering APP proteolysis. Recently, more polymorphisms in the APP ectodomain have been discovered …
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