Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"proteoglycan synthesis"”.
-
Progression of chondrocyte signaling responses to mechanical stimulation in 3-D gel culture
… abolished dynamic compression stimulation of proteoglycan synthesis, independent of effects in free-swell culture, while blocking [alpha]5[beta]1 integrins abolished the effect of compression only when blocking in free-swell increased proteoglycan synthesis. This suggests that disrupting …
-
A tissue engineering strategy for integrative cartilage repair
… neo-tissue. Results indicate that the rate of proteoglycan synthesis was elevated in cartilage explants into which KLD pre-mixed with HB-IGF-1 had been cast; both the explants that had received the enzyme pre-treatment and those that were left untreated had a two-fold increase compared to the …
-
Optimizing chondrogenic factors and protein delivery methods for cartilage repair
… be retained in cartilage matrix and stimulate proteoglycan synthesis with a single dose, whereas unmodified IGF-1 easily diffuses out of cartilage tissue. The RAD peptide was used as a scaffold for retaining growth factor to stimulate encapsulated chondrocytes and adjacent cartilage tissue. RAD …
-
In vitro comparison of equine tendon- and bone marrow-derived cells expanded with FGF-2 prior to culturing with tendon matrix and IGF-I
… supplementation significantly increased collagen synthesis of bone marrow-derived cells. Monolayer expansion with FGF-2 followed by IGF-I supplementation significantly increased proteoglycan synthesis in tendon-derived cells. In summary, tendon-derived cell cultures generated more cells and showed …
-
Effects of heparinoids on bovine aortic smooth muscle cells
… lengths of heparin treatment on endogenous proteoglycan metabolism in both log and confluent cells was examined. The majority of GAG produced by SMCs is chondroitin sulfate (CS) or dermatan sulfate (DS). Most (90%) of the GAG produced by SMCs is secreted to the culture media. Heparin …
-
Cadherin-Mediated Cell-Cell Interactions Regulates Phenotype And Morphology of Nucleus Pulposus Cells Of The Intervertebral Disc
… changes in NP cell phenotype, morphology and proteoglycan synthesis that may contribute to IVD degeneration. Studies demonstrate healthy, juvenile NP cells exhibit potential for preservation of multi-cell clusters and NP cell phenotype when cultured upon soft, laminin-containing substrates; …
-
Investigation of Cellular Responses Activated by Mechanical Compression in Equine Chondrocytes: Device Design, Construction and Testing
… Chondrocytes can respond to these forces through synthesis or degradation of extracellular matrix and changes in gene expression. The overall objective of this study was to investigate the effects of mechanical compression on gene regulation, proteoglycan (PG) synthesis and activation of signaling …