Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 128 for “"proteoglycan"”.
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Extracellular Proteoglycan Decorin in Bovine Mammary Physiology
… synthesis, and secretion. Decorin is an ECM proteoglycan known to impact mammary cell proliferation in humans and rodents. Prior to this work, very little was known about decorin in bovine mammary biology. A series of bovine mammary cell culture experiments was conducted. The first experiment …
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Proteoglycan genes and anterior cruciate ligament injury susceptibility
… injury susceptibility, specifically in females. Proteoglycans have also been implicated in having important functions in fibrillogenesis and maintaining the structural integrity of ligaments. Moreover, their content appears to be lowered in ruptured ACL tissue in comparison to non-ruptured …
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Transport studies of component proteoglycan molecules through cartilage
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability
Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular matrix (ECM) and basement membrane (BM) and have both structural and signaling roles. Perlecan is a secreted ECM-localized HSPG that contributes to tissue integrity and cell-cell communication. In this thesis, I …
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Purification and Characterization of the Drop-1 Proteoglycan in Drosophila Melanogaster
In an effort to identify molecules involved in Drosophila fertilization, probes against these molecules were generated. Using Drosophila testis as antigen, monoclonal antibodies were isolated that recognize three high molecular weight molecules present on Drosophila sperm and in the fertilized egg. …
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Studies on the Asparagine-Linked Oligosaccharides From Cartilage-Specific Proteoglycan (Chondrocytes)
… synthesize and secrete a cartilage-specific proteoglycan (PG-H) as one of their major products. This proteoglycan has attached to it several types of carbohydrate chains, including chondroitin sulfate, keratan sulfate, O-linked oligosaccharides, and asparagine-linked oligosaccharides. The …
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Analysis of the Proteoglycan Content in Fresh and Cryopreserved Porcine Cardiovascular Tissues
… to study the effects of cryopreservation on the proteoglycan (PG) and mineral content of aorta conduit tissue. Proteoglycans from fresh and cryopreserved porcine aorta conduit tissues were isolated by extraction with 4 M guanidine (Gdn) - hydrochloride (HCl) for 48 hours. Quantitative analysis of …
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Proteoglycan-4 in Equine Joint Disease, Exercise, and in vitro Cartilage Repair
Proteoglycan-4 (PRG4) and hyaluronan (HA) are biological macromolecules with varied and diverse functions distributed throughout the body. In synovial fluid (SF), PRG4 and HA provide independent and synergistic contributions to tissue health and cartilage boundary lubrication. The biological …
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Characterization of heparan sulfate proteoglycan receptor from a permanent rat liver cell line
… demonstrate the existence of a heparan sulfate proteoglycan (HSPG) specific receptor on the cell surface of rat liver cell (RLC), and to characterize the specificity of the ligand-receptor interaction, the properties of the receptor, and the importance of the receptor in HSPG metabolism.
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Fluorous assisted one-pot oligosaccharide synthesis and chemical synthesis of homogeneous heparan sulfate proteoglycan
… synthesized using this method. Hpearan sulfate proteoglycans (HSPGs), including syndecans and glypicans, are ubiquitous components of mammalian cell surface and extracellular matrix and they play important roles in various biological processes such as cancer development, angiogenesis. viral …
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Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function
… methods depend on cell surface heparan sulfate proteoglycans (HS PGs) for efficient uptake, however the details of this mechanism and the exact role of the PG has been unclear. The aim of this thesis was to clarify the role of the cell surface PG in macromolecular uptake processes. It is …
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Correlation of Heparan Sulfate Proteoglycan Structure and Metabolism With the Regulation of Cell Division
Heparan sulfate proteoglycan (HSPG), a ubiquitous cell surface component in animal cells, is a complex, polyanionic macromolecule consisting of a core protein to which are attached several heparan sulfate (HS) chains. Growing and confluent cultures of a rat hepatocyte cell line were labeled with …
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Predicting Articular Cartilage Constituent Material Properties Following In Vitro Growth Using a Proteoglycan-Collagen Mixture Model
… </a><a id="x-_anchor_3"></a> proteoglycan Cauchy stress function was developed based on the continuum electromechanical Poisson-Boltzmann unit cell model for proteoglycan interactions. The resulting proteoglycan model was combined with a novel collagen fibril model and a ground …
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Metabolism of Heparan Sulfate Proteoglycan in Rat Hepatocyte Cell Line and Its Role for Regulation of Cell Growth
… exogenous ($\sp{35}$SO$\sb4$) heparan sulfate proteoglycan (HSPG) was taken up by the cells and converted to free chains and about 10 percent of the internalized HS was transported into nucleus.
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Effects of sodium hyaluronate and triamcinolone acetonide on proteoglycan metabolism in equine articular chondrocytes treated with interleukin-1
… acetate (TA) can mitigate chondrocyte proteoglycan catabolism caused by interleukin-1 (IL-1) administration. Chondrocytes were collected from fetlock joints of ten horses euthanized for reasons unrelated to joint disease. Chondrocyte pellets were treated with media (negative control); …
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Identification, molecular cloning, and characterization of cerebroglycan, a cell surface heparan sulfate proteoglycan of the developing rat brain
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Purification and Characterization of Proteoglycan from Bovine Aortic Endothelial Cells Conditioned Media, and its Interaction with Basic Fibroblast Growth Factor (bFGF)
… found to synthesize and secrete heparan sulfate proteoglycans (HSPG), which bound basic fibrobalst growth factor (bFGF). bFGF is a known mitogen for vascular smooth muscle cells, and is indicated to have a role in some proliferative vascular disorders. In the present study, we have purified …
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