Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"proteinase inhibitors"”.
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Comparison of Murine Epididymal and Seminal Vesicle Proteinase Inhibitors.
Mammalian sperm must undergo a long and circuitous journey to reach their goal of fertilizing the ovum. This journey begins with sperm production in the seminiferous tubules of the testes.
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The roles of proteinases and proteinase inhibitors in plant-nematode interactions
… this study was to investigate the roles of plant proteinase inhibitors in plant-nematode (Meloidogyne spp.) interactions. Transgenic tomato and tobacco plants were employed to examine the effects of proteinase inhibitor I or II transgene on nematode disease development. In the first part of this …
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Establishment of a transformation procedure to study the role of trypsin inhibitors in soybean
The major serine proteinase inhibitors Kunitz and Bowman-Birk-type trypsin are key anti-nutrients responsible for the low nutritional value of raw soy cake, the by product of oil expression from soybean. Traditionally, proteinase inhibitors are eliminated from soy cake through intensive heating, …
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Chemical synthesis, cloning and expression of a gene encoding systemin, a proteinase inhibitor-inducing factor
Wound-inducible proteinase inhibitors in plants elicit a defence mechanism by inactivating the proteinases of insects. This triggers a feedback mechanism causing overproduction of digestive enzymes together with a decrease in appetite, leading to starvation. System in, a polypeptide proteinase …
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Cloning and expression of a modified oryzacystatin inhibitor gene and an investigation of its inhibitory capabilities
Cysteine proteinase inhibitors have shown potential as biocontrol agents for the protection of plants against insect and pathogen attack. With the advent of protein and genetic engineering such inhibitors can now be modified in order to improve their effectiveness. Because cystatins have already …
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QUB-1904: A Bioactive Peptide from the Frog Skin Secretion of Pelophylax esculentus
Bowman-Birk type proteinase inhibitors (BBIs) is a typical family of canonical serine protease inhibitors specially derived from plants which can inhibit serine proteases, like trypsin and chymotrypsin. BBIs have various functions, such as for suppress cancer cell proliferation and decrease …
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A Ca²⁺-activated proteinase in chicken skeletal muscle
… rnM Ca²⁺), pH optimum (7.2) and sensitivity to proteinase inhibitors (inhibited by leupeptin and chymostatin). Both embryonic and adult enzymes were found to have molecular weights of 112000 daltons by gel filtration on Sephadex G-150. CAP activity was present in cultured skeletal muscle cells …
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Pathways of intracellular protein degradation in cultured muscle cells
… of endogenous muscle protein, lysosomotropic proteinase inhibitors have been employed to elucidate the relative contributions of lysosomal and non-lysosomal degradation pathways functioning under varying nutritional states and for different classes of intracellular proteins. Proteolysis in …
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Targeting bacterial infections by using immunomodulatory host defence peptides and proteins
… discovered. HCII belongs to the class of serine proteinase inhibitors (serpins) and specifically inhibits human thrombin. However, its precise physiological role remained enigmatic. Paper IV shows that cleavage of HCII by human neutrophil elastase induces a conformational change in the HCII …
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Determining the beneficial properties of bovine amniotic membrane and its efficacy as a therapy for corneal healing
… by complex signaling pathways which involve proteinases, proteinase inhibitors, growth factors, and pro- and anti-inflammatory cytokines. For adequate corneal healing, it is necessary to have a well-balanced interaction between proteinases and their inhibitors, as well as anti-angiogenic and …
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Molecular approaches to increasing resistance of wheat (Triticum aestivum L.) towards two insect pests; Cereal aphid (Sitobion avenae F.) and Wheat bulb fly (Delia coarctata Fallen).
… gut proteases and their inhibition by host plant proteinase inhibitors (PIs). Investigation of proteolytic digestion in S. avenae gut showed that in spite of being a phloem-feeding insect, cereal aphid could digest ingested protein, using cysteine proteases. D. coarctata larvae contained mainly …
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The Role of Serine Protease Inhibitors in Regulating Hepatotoxicity During Viral Infection
… and clearance of hepatic viral infections. Human proteinase inhibitor 9 (PI-9/ serpinB9) and the murine orthologue, serine proteinase inhibitor 6 (SPI-6/ serpinb9) are members of a family of intracellular serine proteinase inhibitors (serpins). PI-9 and SPI-6 expression in immune-privileged cells, …
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The Utilization of the Hmg2 Inducible Promoter to Genetically Engineer Parasite Resistance in Tobacco
… strategy was employed utilizing the tomato proteinase inhibitor I (PI-I) gene as a nematode specific toxin. Transgenic tobacco plants were generated that expressed genes encoding an intracellarly retained or secreted form of tomato PI-I under the control of the nematode-inducible promoter, …
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Contribution of LEDGF/p75 to Prostate Cancer Chemoresistance
<p>Prostate cancer (PCa) is the second leading cause of male cancer death in the United States, and is considered a health disparity because of its disproportionate incidence and mortality in African American (AA) males. A major challenge in PCa treatment is its recurrence into hormone refractory …