Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"proteinase 3"”.
-
Proteinase 3 and Neutrophil Apoptosis in ANCA-Associated Systemic Vasculitis
ANCA-Associated Systemic Vasculitis (AASV) is characterized by leukocytoclasis- dying neutrophils surrounding small blood vessels. Previous studies have shown increased plasma PR3 and increased proportion of neutrophils expressing plasma membrane-associated PR3 (mPR3+). Neutrophils were isolated by …
-
Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
… serine proteases neutrophil elastase (NE) and proteinase 3 (P3). NE and P3 are primarily expressed in cells of myeloid lineage including granulocytes, bone marrow progenitors and myeloid leukemia. Our lab reported that NE and P3 are cross-presented by antigen presenting cells (APCs) and solid …
-
Probing the sensitivity of autoantibody production to B cell depletion by Rituximab
… and following clinical remission, IgG anti-Proteinase 3 autoantibody titres fell gradually. All other measured antibody titres remained little changed. These findings favour the hypothesis that autoantibody producing plasma cells are sustained by disease related inflammation. Subsequent …
-
Diagnostic and prognostic aspects of anti-neutrophil cytoplasmic antibodies in systemic vasculitis
… antibody 4A3 for detection of antibodies against proteinase 3 (PR3-ANCA) was evaluated and found to have a high sensitivity and specificity. It was shown that patients with high levels of PR3-ANCA as measured by the capture ELISA have a poorer survival and worse renal outcome and are more prone to …
-
Cross-Presentation Is A Source of Tumor Antigens For Multiple Myeloma Immunotherapy
… is derived from neutrophil elastase (NE) and proteinase 3 (P3), and the ability to treat multiple myeloma using PR1-targeting immunotherapies. Here we demonstrate that multiple myeloma cells lack endogenous NE and P3 expression, possess the ability to take up exogenous NE and P3 and …
-
Kinin System Activation in Vasculitis
… We also found that neutrophil-derived proteinase 3 (PR3) cleaves HK liberating a novel vasoactive kinin, termed PR3-kinin. PR3-kinin binds to and activates kinin B1-receptors both in vitro and in vivo. In addition, PR3-ANCAs from patients with vasculitides inhibit PR3-induced HK …
-
The role of complement and granulocyte colony stimulating factor in ANCA associated vasculitis
… in 1982, with myeloperoxidase )) and proteinase 3 (PR3) subsequently shown to be the antigenic targets responsible rthe perinuclear and cytoplasmic staining patterns, respectively. Infection is thought to erbate disease partially through the production of the proinflammatory cytokine …
-
T Helper Cell Dysfunction in ANCA Associated Vasculitis
… neutrophil enzymes, myeloperoxidase (MPO) and proteinase 3 (PR3). Genome-wide association studies that identified the relationship between MHC class II genes and ANCA specificity strongly support the role of CD4 T helper cells in the pathogenesis of AAV. Recently a new subset of T cells called …
-
Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD
… a plasma signature of increased protease (NE and proteinase 3) activity was identified in COPD versus healthy control plasma. In conclusion, hypoxia engenders a destructive neutrophil phenotype, with enhanced release of histotoxic proteins and increased capacity to cause endothelial injury. This …
-
Cellular Uptake of Neutrohpil Elastase Links Inflammation to Adaptive Immunity
… We also show that after taking up NE and proteinase 3 (PR3), a second primary granule protease with significant homology to NE, breast cancer cells cross-present the NE- and PR3-derived peptide PR1 rendering them susceptible to PR1-targeted therapies. Taken together, our data support a …
-
The development of a humanised mouse model of ANCA associated vasculitis
… protein granules myeloperoxidase (MPO) and proteinase 3 (PR3), activate neutrophils in vitro, and are associated with a systemic autoimmune vasculitis, in which a pauci-immune crescentic glomerulonephritis is common. The in vivo study of ANCA pathogenesis is severely limited, both by the …
-
The Genetics of Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis (AAV)
… ANCA. There are two main antigenic targets: proteinase 3 (PR3) and myeloperoxidase (MPO). Previous genome-wide association studies (GWAS) have provided evidence that PR3-AAV and MPO-AAV are genetically distinct autoimmune syndromes, though only three loci specific to PR3-AAV and one to …
-
Modulating Avidity of H8F4-Car By Regulation of Expression Via Codon Modification
… from serine proteases neutrophil elastase and proteinase 3, is overexpressed on myeloid leukemia cells, and expressed at normal low levels in healthy hematopoietic cells. We have demonstrated efficacy in targeting PR1/HLA-A2 via the novel development of a TCR-like monoclonal antibody named 8F4 …
-
Identifikation und immunologische Charakterisierung von MHC-Klasse-II-Peptidepitopen in humanen Leukämie- und Lymphom-assoziierten Antigenen
… sind. In dieser Arbeit wurden die Proteine Proteinase 3 (PR3) und Survivin (SVN) - beide Proteine werden mit Leukämien und Lymphomen in Verbindung gebracht ausgewählt. MHC Klasse-II Kandidatenepitope dieser Proteine wurden Computer-basierend vorhergesagt und als synthetische Peptide für in …
-
Characterisation of fibrinogen and fibrin proteolysis by the neutrophil membrane
… neutrophil elastase, cathepsin G and possibly proteinase 3. Electron microscopy analysis of PMA stimulated neutrophils incorporated within fibrin clots revealed morphological changes suggestive of neutrophil degranulation, and the proteolytic activity released by these cells was shown to be …
-
Wegener'sche Granulomatose
… Konformationsepitope der Serinprotease Proteinase 3 (PR3), die in den azurophilen Granula neutrophiler Granulozyten gespeichert wird. Die enge Korrelation PR3-spezifischer Antikörperspiegel mit dem Krankheitsverlauf läßt vermuten, daß sie bei der Pathogenese eine zentrale Rolle spielen …