Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"protein-protein interfaces"”.
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Molecular characterization and evolutionary plasticity of protein-protein interfaces
… as 70% of eukaryotic genes work through multi-protein systems, it is only through detailed study of the interactions of these components, that a more complete, systems-level understanding can be gained. This thesis is centred on the establishment of PICCOLO - a comprehensive database of …
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Affinity Maturation of Peptides to Bind Protein-Protein Interfaces
The use of peptides as inhibitors for protein-protein interactions (PPI) is an attractive strategy for developing therapeutics. Understanding the structure-activity relationships of peptide-based inhibitors is crucial for optimizing their activity. To guide this optimization, combinatorial peptide …
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Computational approaches for drug design at the Protein-Protein interface
… to design drugs that disrupt formation of protein-protein interfaces is of particular interest to the pharmaceutical industry due to its promise for opening an entire new range of drug targets, many of which have already been well characterised in terms of their disease causing effect on …
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Analysis and Error Correction in Structures of Macromolecular Interiors and Interfaces
<p>As of late 2009, the Protein Data Bank (PDB) has grown to contain over 70,000 models. This recent increase in the amount of structural data allows for more extensive explication of the governing principles of macromolecular folding and association to complement traditional studies focused on a …
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Engineering the interface of cytochrome b5 and myoglobin for in vitro and in vivo applications
Heme-copper oxidases (HCOs) are large membrane proteins found in both bacteria and in eukaryotes. They catalyze about 90% of oxygen reduction in the atmosphere. They utilize a heme-copper center, which is comprised of a heme and a copper ion coordinated with three histidines, to catalyze the …
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Refining computer-aided drug design routes for probing difficult protein targets and interfaces
… limitations when exploring how to target certain protein classes, including membrane-embedded or protein-protein bound, due to the complexity of their environments. These two domains of research are experimentally challenging to explore, and in silico research practices provide insight that would …
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Small molecule inhibition of immunoregulatory protein-protein interactions
Selective molecular recognition between proteins is a fundamental event in biological processes that governs cellular growth, function, survival, and differentiation. The immune system, for example, is a complex network of cellular processes regulated by protein-protein interactions (PPIs) between …