Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"protein-DNA complex"”.
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Modulation of Transcription Factor Activity by Mono-Ubiquitin
… of the 26S proteasome can destabilize activator-DNA complexes in a non-proteolytic manner that requires direct interactions between the Rpt4 and 6 subunits with the activation domain of the activator. Remarkably, mono-ubiquitylation of the activator blocks this repressive activity. In this study, …
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Electrostatics and packing in biomolecules : accounting for conformational change in protein folding and binding
The role of electrostatics and packing in protein folding and molecular association was assessed in different biomolecular systems. A continuum electrostatic model was applied to long-range electrostatic effects in the binding of human carbonic anhydrase II to a sulfonamide inhibitor. The effect of …
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Characterization of Aryl Hydrocarbon receptor and Kruppel-Like-Factor-6 interaction
… to the nucleus, dissociates from its chaperone complex, and dimerizes with the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT). The canonical AhR-ARNT complex binds to DNA regions known as Xenobiotic Response Elements (XRE), inducing the transcription of target genes. Our previous results …
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Systematic conformational search with constraint satisfaction
… separate project to determine the structure of a protein-DNA complex by X-ray crystallography. The purpose of the systematic search method is to enumerate all conformations of a molecule (at a given level of torsion angle resolution) that satisfy a set of local geometric constraints. Constraints …
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Helicase-Initiated Assembly of Macromolecular Machines Involved in DNA Replication
… formation of the primosome, a large protein-DNA complex, in E. coli, responsible for the restart of the DNA replication after the damage. The primosome, in its final state, comprises of as many as seven different proteins: PriA and DnaB helicases, DnaC, DnaG, DnaT, PriB, and PriC. …
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The role of topoisomerase II in amsacrine resistance
… been shown to induce topoisomerase II-associated DNA breaks both in cultured mammalian cells and in vitro in the presence of purified mammalian DNA topoisomerase II. However, mechanisms linking these protein-associated DNA breaks with drug cytotoxicity are poorly understood. Whether this type of …
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Electrochemical detection of interactions between DNA and various ligands
Antibodies specific for DNA, with varying degrees of sequence specificity, are common in many autoimmune diseases including systemic lupus erythematosus. The presence of anti-DNA antibodies is a useful determinant in arriving at a prognosis in these conditions. Given the prevalence of these …
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STRUCTURAL ANALYSES OF TRANSCRIPTION FACTOR/DNA COMPLEXES: NFI-X AND NF-Y
… analysis is the key to understanding their DNA-binding mode and for the design of specific inhibitors. In this context, the present PhD project focuses on two TFs: (1) NFI-X, a TF with unknown structure that binds to the palindromic motif TTGGC(n5)GCCAA and plays an essential role in …
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The role of Bacteroides Host Factor A in CTnDOT integration and Holliday junction resolution
… spp. benefit the host by breaking down complex polysaccharides. However, when the gut is punctured, these species may escape to cause abscesses or infections within the blood. In the past, tetracycline was used as a treatment for these infections. However, Bacteroides opportunistic …