Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"protein turnover"”.
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The role of individual protein turnover in skeletal muscle adaptation
… changes in the abundance of individual proteins. The proteome represents a highly dynamic and versatile entity that coordinates the adaptive response of skeletal muscle through adjustments in individual protein turnover as well as abundance. Until very recently, research relating to …
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Regulation of Protein Turnover during Hyper-osmotic Stress in Skeletal Muscle
… to examine the effect of hyper-osmotic stress on protein turnover in skeletal muscle tissue using an established in-vitro model. Rat EDL muscles were incubated in either hyper-osmotic (400 ± 10 Osm) or isoosmotic (290 ± 10 Osm) custom-modified media (Gibco). L-[14C]-U-phenylalanine (n=8) and …
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Protein Turnover in Rat Skeletal Muscle During In Vitro Hypo-Osmotic Stress
… influences tissue metabolism, but research on protein turnover in skeletal muscle is limited. The purpose of this investigation was to examine the effects of hypo-osmotic stress on protein turnover in rat skeletal muscle. We hypothesized increased protein synthesis and reduced degradation …
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Essential Amino Acid (EAA) Regulation of Skeletal Muscle Protein Turnover with Age
… vitro studies model how EAA can regulate muscle protein synthesis (MPS), the relevance of these models to muscle protein breakdown (MPB) and the presence of physiological EAA concentrations remains to be established. Therefore, the objective of this study was to determine the effects of a low, …
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Examining the Influence of Muscle Fiber Type on Protein Turnover Signaling in Growing Pigs
… occurs through myonuclear accretion and high protein turnover rate. While fiber type composition of the muscle could affect protein turnover rate, less is known about how fiber type influences the regulation of protein synthesis and degradation signaling pathways. Thus, the hypothesis of this …
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Skeletal Muscle Protein Turnover During Cancer Cachexia In the Apc<sup>min/+</sup> Mouse
… exhibits an imbalance in the rate at which proteins are synthesized and degraded, referred to as protein turnover. Our laboratory has shown the ApcMin/+ mouse, a model of colorectal cancer is an excellent model to study the progression of cachexia due to the gradual decline in body weight …
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Influence of dietary amino acid adequacy on performance and muscle protein turnover in poults
… to investigate changes in muscle composition and protein turnover in response to essential (EAA) and nonessential amino acid (NEAA) supplementation of the low protein diet. Developmental changes in muscle metabolism as well as differences between muscles were also examined. Protein synthesis was …
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The Effect of Cancer Cachexia Progression on the Feeding Regulation of Skeletal Muscle Protein Turnover
… Cancer-induced cachexia disrupts skeletal muscle protein turnover (decreasing protein synthesis and increasing protein degradation). Skeletal muscle’s capacity for protein synthesis is highly sensitive to local and systemic stimuli that are controlled by mTORC1 and AMPK signaling. During cachexia, …
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Local Protein Turnover As a Regulatory Mechanism of Growth and Collapse of Neuronal Growth Cones
… Wachstumskegel Oberflächenrezeptoren und Signalproteine welche den Umbau von Strukturproteinen, zum Beispiel Aktin, Tubulin, Spektrin oder Neurofilament, beeinflussen. Angesichts der grossen Distanz zwischen Wachtumskegel und Zellkörper sind lokale Möglichkeiten zur Regulation der Proteinmengen …
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The effect of leucine and dileucine ingestion on muscle protein turnover in healthy young men
… is determined by day-to-day changes in muscle protein synthesis (MPS) and muscle protein breakdown rates (MPB), are important determinants of physical performance and metabolic health across all age groups. As such, identifying nutritional and exercise strategies that more robustly stimulate …
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Effects of physical activity levels and nutritional intake on skeletal muscle protein turnover and cellular signaling
… levels (combined with essential amino acids) on protein turnover and cellular signaling following resistance exercise, and to investigate similar parameters in response to various combinations of anabolic nutrients. Stable isotopic techniques with arterial/venous catheterization and muscle …
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The whole-body protein turnover response to the ingestion of intrinsically labeled eggs at rest and after endurance exercise
… been on the ingestion of dietary or supplemental protein to maximize skeletal muscle protein synthesis to facilitate remodeling (e.g., growth and repair of muscle). However, considerably less attention has been paid to the repletion of exercise-induced oxidative losses at the whole-body level. …
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Characterization of estrogen and glucocorticoid receptors, skeletal muscle protein turnover and tissue growth in lambs treated with trenbolone acetate and estradiol
… glucocorticoid and E2 receptor, skeletal muscle protein turnover and tissue growth. Twenty-four lambs were utilized. Trenbolone acetate did not ,affect (P>.10) degradation rates in the semitendinosus (ST) and triceps brachii (TB) muscles, the production of cortisol, adrenal weights and cytosolic …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… axon. Due to their distinct functions, precise protein localization within neurons is essential for maintaining neuronal homeostasis. Certain proteins exhibit notable enrichment in axon terminals, where they exert pivotal influences on neuronal function, morphology, and survival. Dual Leucine …
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Effect of Severe Burn Injury on Body Composition and Muscle Metabolism in Pediatric Patients
… for wound healing and production of acute phase proteins. However, there is a paucity of data concerning acute body composition changes in response to burn trauma, or factors that influence burn-induced muscle wasting. The objectives of this dissertation are 1) to quantify the extent of body …
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Persistent “hijacking” of brain proteasomes in HIV-associated dementia
… deposits and high molecular weight ubiquitin-protein conjugates in brains of HIV-positive subjects suggest impaired protein turnover by the ubiquitin-proteasome system analogous to neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. HIV infection of the brain and …
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Autophagy in the developing Drosophila brain
… of autophagy to lipid droplet formation and protein turnover in the neural stem cells, neurons, and glia of the larval Drosophila brain. The role of the endomembrane system in autophagy in neurons and neural stem cells was also considered, as was the movement of acid-resistant protein from …
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Protein Utilization and Requirements in Broiler Breeders
… to curb excessive body weight gain, both the protein requirements and feeding strategies of broiler breeders are being revisited. A series of studies were conducted to determine the protein and amino acid requirements of broiler breeders during the production phase and to determine the …
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