Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"protein structure-function"”.
-
Evolution of protein structure function
Proteins are generated as a result of millions of evolutionary experiments over a billion years. These experiments are constrained by proteins structure and function. Investigating genomics data is a natural way for mining these constraints to address long-standing biological challenges. In this …
-
Evolution of protein structure, function, and dynamics in biological systems
… vary with different levels of granularity of the structure of biological systems. Different levels of organization and their parts often use similar strategies to achieve different goals. For example, at the organismal level cellular and viral proteomes leverage disorder to achieve advanced …
-
Molecular Biology of the Cytochrome O Terminal Oxidase of Escherichia Coli (Cloning, Sequencing, Dna)
… locus will provide valuable information on the protein structure-function relationships.
-
Probing Orthologue and Isoform Specific Inhibition of Kinases using In Silico Strategies: Perspectives for Improved Drug Design
… prevalent for providing useful insight into protein structure-function relationships, offering new information to researchers about drug discovery strategies. This work utilizes streamlined computational techniques on an atomistic level to aid in the identification of orthologue and isoform …
-
Elucidation and Characterization of Glycosyltransferases Implicated in Pectic Polysaccharide Biosynthesis in Arabidopsis thaliana
… and pectic polysaccharides that confers multiple functions to plant cells and the plant as an organism. Glycosyltransferases (GTs) are enzymes that catalyze the transfer of a sugar molecule from an activated sugar-nucleotide donor to an acceptor substrate, and these enzymes are responsible for …
-
Analysis of Structure-Function Relationships in *Lambda and HK022 Site -Specific Recombination
This thesis presents a multifaceted analysis of protein structure-function relationships pertaining to the Lambda and HK022 Integrase proteins (Int). First, homology-based modeling was used to create a three-dimensional model of the Lambda Int core-binding (CB) domain. The model suggests that all …
-
Exploring the interaction between asymmetric phosphonates and acetylcholinesterase. Probing the gorge and P-site via customized covalent modification
… of this enzyme and an opportunity to explore protein structure, function and mechanism. The goal of this study is: 1) to show how covalent modification of AChEs by chromophore-linked OPs can be used to probe the active and peripheral sites of the protein and its local environment; 2) to …
-
Exploring the interaction between asymmetric phosphonates and acetylcholinesterase. Probing the gorge and P-site via customized covalent modification
… of this enzyme and an opportunity to explore protein structure, function and mechanism. The goal of this study is: 1) to show how covalent modification of AChEs by chromophore-linked OPs can be used to probe the active and peripheral sites of the protein and its local environment; 2) to …
-
Membrane protein conformational dynamics and ligand-binding interactions in bacterial glycoconjugate biosynthesis
Membrane associated proteins are an essential component of the complex biochemistry that is carried out at the membrane interface and perform essential functions for cellular life. Biophysical characterization of protein structure-function relationships faces a unique set of challenges due to the …
-
Cellular influence on protein folding
Advances in the study of protein folding and structure have greatly expanded our understanding and ability to predict and modify protein structure and, increasingly, even function. Attention has now turned to developing a better understanding of how protein structure, function, and folding interact …
-
Modelling the structural, functional and phenotypic consequences of protein coding mutations
Proteins are integral to all cellular processes and underpin the function of all extant organisms, meaning variants impacting them are a primary cause of phenotypic variation. Protein coding variants are a key area of study in biology, with relevance from structural and molecular biology to …
-
Refining computer-aided drug design routes for probing difficult protein targets and interfaces
… limitations when exploring how to target certain protein classes, including membrane-embedded or protein-protein bound, due to the complexity of their environments. These two domains of research are experimentally challenging to explore, and in silico research practices provide insight that would …
-
Protein Engineering for Biomedical Materials
The inherent design freedom of protein engineering and recombinant protein production enables specific tailoring of protein structure, function, and properties. Two areas of research where protein engineering has allowed for many advances in biomedical materials include the design of novel protein …
-
Extending Students' Practice of Metacognitive Regulation Strategies in the Undergraduate Chemistry Laboratory and Investigation of Pb2+ Binding to Calmodulin with Circular Dichroism and Molecular Dynamics Modeling
… strategies. Students claimed that the structure of the SWH weekly laboratory experiments improved their ability to solve open-ended lab problems. This research not only provided a lens into students' descriptions of their regulation strategy practices in the laboratory, but it also …