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Showing 1 to 20 of 29 for “"protein structure and function"”.
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Computational methods for the analysis of protein structure and function
The vast majority of known proteins have not yet been experimentally characterized and little is known about their function. The design and implementation of computational tools can provide insight into the function of proteins based on their sequence, their structure, their evolutionary history …
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X-ray compatible microfluidic platforms for studying protein structure and function
If you can look into the seeds of time, And say which grain will grow and which will not. - Macbeth. Act I, Scene 3. Knowledge of the three dimensional structure of a protein provides insight into its mechanism, as well as into potential sites for drug targeting. Often these insights provide …
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Development of Dendrimer-based Technologies for Phosphoproteomics and Glycoproteomics in Biomarker Discovery
… of post-translational modifications (PTMs) of proteins keeps cells adapting to the ever-changing microenvironment by regulating protein structure and function in the real-time mode. Of all PTMs, protein phosphorylation and glycosylation are undoubtedly two of the most common and important PTMs …
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Computational and NMR Investigations of Protein Structure
… thesis represents an effort to better understand the structure of proteins, and to suggest new spectroscopic information which might be used to improve the resolution of such structures. Variations in spectroscopic observables are correlated with variations in the local geometry and …
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From Probes to Cell Surface Labelling: Towards the Development of New Chemical Biology Compounds and Methods
Chemical biology encompasses the study and manipulation of biological system using chemistry, often by virtue of small molecules or unnatural amino acids. Much insight has been gained into the mechanisms of biological processes with regards to protein structure and function, metabolic processes and …
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Experimental and Computational Studies in Bioorganic and Synthetic Organic Chemistry
… Ï interaction is an important determinant in protein structure and function. Among the three proteinogenic aromatic amino acids, tryptophan (Trp) is the strongest cationâ Ï donor. We reported the asymmetric syntheses of tryptophan regioisomers in which the amino acid side chain is attached at …
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A preliminary study of genetic variation within and among populations of Diaptomus leptopus (Copepoda: Calanoida) : a DNA sequence analysis of the Mitochondrial Cytochrome Oxidase I gene
Previous studies examining the population structure of aquatic organisms have been based generally on behavioral traits, morphological traits and allozyme studies. DNA sequence analysis of the mitochondrial cytochrome oxidase I gene may also be of use to study population structure. Thus, a study …
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Genome data analysis, protein function and structure prediction by machine learning techniques
… it is still a big challenge for people to understand them, and extract useful structure and function information, such as the function of genes, the structure of proteins encoded by gene, and the function of proteins. Understanding these information is crucial for us to improve longevity and …
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Molecular characterisation of the mechanisms of compatible solute accumulation in Listeria monocytogenes
… pathogen Listeria monocytogenes to survive and grow in environments of elevated osmolarity can be attributed, at least in part, to the accumulation of a restricted range of low molecular mass solutes compatible with cellular function. Accumulated to high internal concentrations in …
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Learning the language of biomolecular interactions
Proteins are the primary functional unit of the cell, and their interactions drive cellular function. Interactions between proteins are responsible for a wide variety of functions raning from catalytic activity to cellular transport and signaling, and interactions between small molecules and …
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Enabling tools for de-novo single molecule protein sequencing
Proteins are the functional units of all living cells and the subsequent product of many genes. Subtle changes in protein structure and function can cause deleterious effects and, in cases of critical protein units, precipitate large-scale biological dysfunction. Amino acids are the fundamental …
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The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels
The pentameric ligand gated ion channel super family plays a central role in fast synaptic communication between neurons and at the neuromuscular junction. Extensive studies on the prototypic pLGIC, the Torpedo nicotinic acetylcholine receptor (nAChR) have revealed an exquisite lipid sensitivity, …
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Genetic and functional investigation of sequence variation associated with the related phenotypes: birth weight, obesity, and type 2 diabetes (T2D)
Background: Global incidence of obesity and Type 2 diabetes (T2D) has increased rapidly in the last fifty years and even more rapidly in immigrant ethnic minority communities in Western countries. There is evidence of a connection between birth weight and the subsequent risk of obesity and T2D in …
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A FRET Investigation into Molecular Mechanisms of Cardiac Troponin Activation in Reconstituted Thin Filaments
… (CM) are the leading cause of death in America, and can develop from mutations in sarcomeric proteins, leading to altered protein structure and function. Current therapies target upstream signaling pathways to treat the symptoms of heart failure, but are associated with increased mortality by …
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On Two Problems in Comparative Genomics of Eukaryotes
… extent to which this prediction directly affects protein structure and function, I used computational methods to identify positions of proteins conserved in long-lived but not in short-lived mammal species. I analyzed 7,590 orthologous protein families in 33 mammalian species, accounting for body …
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Post-Translational Modification of Proteins via Ambient Air Pollutants and Endogenous Reactive Species
<p>Proteins can react with reactive oxygen species (ROS) and reactive nitrogen species (RNS) to form post-translational modifications (PTMs), which can affect protein structure and function. The formation of 3-nitrotyrosine (NTyr) and dityrosine (DiTyr) upon reaction of proteins with ROS/RNS are …
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Modelling the structural, functional and phenotypic consequences of protein coding mutations
Proteins are integral to all cellular processes and underpin the function of all extant organisms, meaning variants impacting them are a primary cause of phenotypic variation. Protein coding variants are a key area of study in biology, with relevance from structural and molecular biology to …
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Development and Application of Solid-State NMR Methods for Investigating Protein Structure and Dynamics
… is uniquely well-suited among spectroscopic and microscopy techniques for studying the structure and dynamics of biomacromolecules with atomic length-scale resolution. The development and application of advanced SSNMR techniques facilitates the study of novel systems to understand protein …
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Molecular basis of the evolution of new protein functions: Kemp elimination and phosphoryl transfer reactions
… into the molecular basis of the evolution of new protein functions. The broad objective of this work was to determine exactly how a series of single amino acid mutations, typical of an evolutionary trajectory, can result in dramatic changes in catalytic activity, specificity and protein …
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Molecular basis of the evolution of new protein functions: Kemp elimination and phosphoryl transfer reactions
… into the molecular basis of the evolution of new protein functions. The broad objective of this work was to determine exactly how a series of single amino acid mutations, typical of an evolutionary trajectory, can result in dramatic changes in catalytic activity, specificity and protein …
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