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Showing 1 to 7 of 7 for “"protein sequence analysis"”.
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Molecular characterization of the cell division gene ftsZ in Neisseria gonorrhoeae.
… 1179 bp open reading frame, encoding a 41.3 kDa protein. Sequence analysis has shown the gonococcal FtsZ to be highly similar to other known FtsZ proteins, with conservation of the GTP binding motif. In vitro transcription/translation shows the gene encodes a protein migrating at 43 kDa. Western …
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Analysis of maturation-specific genes in soybean seeds: Gene structure, desiccation induction and abscisic acid responsiveness
… cDNA clone corresponding to the 31 kDa MAT protein, we were able to isolate and characterize two closely-related gene sequences represented by the pMat1 and pMat9 clones. Primer extension studies indicated that these two clones were full length cDNA clones. In the soybean genome, we …
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Using sequence data to investigate the functional design of proteins
Understanding which sequence features enable a given protein to perform a specific function is a long-standing challenge in the field of molecular biology. In particular, the detection of functional specificity among paralogous proteins is challenging, since their common molecular origin causes …
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Developing as assay to screen inhibitors for various ATP-dependent ligases
… vaginalis (TV), a pathogenic protozoan parasite. Protein sequence analysis of TV DNA ligase indicates a strong sequence similarity to DNA ligase I homologues. The activity of recombinant TV DNA ligase I (TVlig) was investigated using protein expressed in E.coli cells. The TVlig gene product is 76 …
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The plasma protein fetuin: common structural features of the mammalian fetuin family
… expression of the bovine plasma glycoprotein fetuin and its homologues in other species has been examined. From the known partial amino acid sequence of bovine fetuin, degenerate oligonucleotide probes were designed. These probes were end-labelled using 14 polynucleotide kinase and …
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Regulation of the oncogenic PIM1 kinase by SUMOylation
… 1) is a constitutively active serine/threonine protein kinase that is induced physiologically by the JAK-STAT and NF-κB pathways. PIM1 mediates<br/>survival signalling in cells, and contributes to the development of resistance towards chemotherapy and radiotherapy. It is also overexpressed in a …
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Exploring Sequence-Structure-Function Relationships in Proteins Using Classification Schemes
With the rapid growth in the number of available protein sequences and structures, the necessity of interpreting this data in comprehensive and meaningful ways becomes increasingly apparent. Identifying and categorizing the functional, structural, and evolutionary relationships between proteins is …