Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"protein restriction"”.
-
Prenatal and Postnatal Protein Restriction in the Rat: Effects on the Composition of the Brain and of Isolated Myelin and Prospects for Rehabilitation
Made available in DSpace on 2015-05-12T22:36:30Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7511781.PDF: 4690797 bytes, checksum: d63f90ab7f4d05f410fa0493ebddebb2 (MD5) Previous issue date: 1974
-
Influence of Maternal Protein Restriction in Primiparous Heifers During Mid- And/Or Late Gestation on Dam Performance and Progeny Growth, Carcass Characteristics, and Gene Expression
… using HCW as a covariate (P > 0.10). Maternal MP restriction throughout mid- and late gestation (R-R) or in late gestation only (CON-R) down-regulated (P < 0.05) genes involved in muscle tissue development compared to CON-CON progeny at birth. Prior to harvest, progeny restricted in late gestation …
-
Role of Vitamin D receptor and vitamin D binding protein restriction fragment length polymorphisms in determining dose response to vitamin D: a randomized double blind placebo controlled trial
… serum 25OHD such as weight, race, sex, binding protein and the effect of vitamin D receptor (VDR) and vitamin D binding protein (DBP) single nucleotide polymorphisms (SNPs) on serum 25OHD levels. | The primary objective of this study was to determine the effect of genotypes based on VDR and DBP …
-
Autophagy: activation, function and regulation by a protein restricted diet during pregnancy and lactation
Developmental protein restriction is associated with numerous diseases including obesity, diabetes and cardiovascular disease, both in the mother and offspring. Recent intensive research efforts have focused on the mechanisms behind the effects of a maternal low protein diet on diseases in …
-
Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD
… later life.<br/><br/>Animal models of maternal protein-restriction during pregnancy can induce hypertension, diabetes and endothelial dysfunction in offspring and in some of these models alterations to lung gene expression and lung architecture have been reported. This work established that a …
-
Effect of fatty acids and programming on the immune system
… of clinical relevance and the effect of maternal protein restriction on immune outcomes in two later generations. The first experiment investigated the effect of diets differing in FA composition on the recall response in a mouse model of influenza vaccination. A diet rich in salmon oil resulted …
-
A maternal low-protein diet during gestation induces hepatic autophagy gene expression only in the female offspring Sprague-Dawley rats
Maternal protein restriction is associated with inducting of gene expression programs. Multiple stress-induced genes are known to be activated through eIF2α phosphorylation and induction of activating transcription factor 4 (ATF4), which also potentially play a role in autophagy related-genes …
-
The Role of Amino Acid Transport in the Regulation of mTORC1 by Metformin
… mTORC1 via amino acid transport, akin to hepatic protein restriction. This study highlights the potential for ‘re-purposing’ metformin for use as a protein restriction mimetic in treatment of age-related diseases including cardiovascular disease, cancer and diabetes.
-
The effect of maternal nutrition on offspring gene regulation via epigenetic modulation
… in the mammary glands in vivo under maternal low-protein (LP) diet. One of my published projects examined the effect of maternal low-protein diet on the regulation of the p16 cell-cycle gene expression in the mammary gland of offspring rats. Timed-pregnant Sprague-Dawley rats were fed during …
-
Regulation of Energy Balance by Dietary Protein
The protein leverage hypothesis posits that protein restriction triggers a compensatory hyperphagia to facilitate the acquirement of the animal's protein needs whereas protein excess elicit hypophagia as the animal's protein requirement is met at a lesser calorie intake. However, the effects of …
-
The Mechanism of Mammalian Pexophagy
… pexophagy, identify two peroxisomal membrane proteins which are ubiquitinated by PEX2, and identify NBR1 as the primary receptor in PEX2-mediated pexophagy. In the fourth chapter, I examine the regulation of PEX2 and demonstrate how a key metabolic stimulus, protein restriction, initiates …
-
Fetal programming in cattle: the effects of varying maternal protein intake in adolescent beef heifers on fetal and postnatal growth and development of the calf
… systems. In the northern Australian rangelands, protein, rather than energy, is the major limiting nutrient for cattle in dry-season pastures with protein supplementation of breeding heifers an animal husbandry requirement. Few studies in cattle have specifically evaluated the effects of maternal …
-
Maternal diet and programming of embryo and fetal development in the mouse
… examined the impact of a relatively mild dietary protein restriction in the mouse during pregnancy on the subsequent development of the fetus. The responses of the fetus to the maternal dietary challenge were studied close to the end of gestation (at day 17) using three broadly different …
-
Fetal programming of renal morphology and function
… of a 9% casein diet to pregnant rats, a mild protein restriction, reduced nephron number in the offspring, which progressively declined with age compared to those exposed to an 1 8% control diet. At weaning low-protein exposed offspring had hypertension and evi(leflCC of renal insufficiency. …
-
A role for HSC70 in regulating antigen trafficking and presentation during macronutrient deprivation
Globally, protein malnutrition remains problematic, adversely affecting several systems including the immune system. Although poorly understood, protein restriction severely disrupts host immunity and responses to infection. Induction of high-affinity, long-lasting immunity depends upon …
-
Efeitos da restrição protéica experimental sobre a morfologia do miocárdio e as propriedades mecânicas dos miócitos cardíacos isolados em ratos Fisher após o desmame
Alterações na nutrição em fases precoces da vida resultam no desenvolvimento de adaptações que podem modificar permanentemente a estrutura de um órgão ou tecido. Embora a função cardíaca esteja alterada em animais com restrição protéica, ainda há informações limitadas sobre a mecânica, morfologia e …