Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"protein release"”.
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Investigation of CNT-induced Escherichia coli Lysis and Protein Release
… a plasmid that expressed Green Fluorescent Protein (GFP) and -lactamase were exposed to CNTs under various levels of agitation for different times. Fluorescence assay for GFP, optical absorbance for -lactamase activity, and Transmission Electron Microscopy (TEM) were used to determine the …
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Study of the enhancement effect of cyclopentadecanolide on protein permeation through lipid membranes
… The low bioavailability of simple formulation of protein drugs, such as insulin, can be greatly improved by using permeation enhancers. We studied the effect of cyclopentadecanolide (CPE-215RTM) as a permeation enhancer in protein release through lipid bilayer membranes. We successfully designed a …
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Performance and Mechanisms of Excess Sludge Reduction in the Cannibal™ Process
… was set at about 10%. It was found that the release of protein from the anaerobic bioreactor was greater than that from the aerobic bioreactor. The SOUR data suggested that the released protein from the anaerobic bioreactor was easily degraded when the sludge was returned to the activated …
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Stimulus-secretion coupling in the exocrine pancreas of the rat: Interactions between secretagogues
… (and related compounds) on secretagogueevoked 3H-protein release (ACh & CCK8) and pancreatic juice secretion (CCK8 & Secretin) in the rat pancreas. 2. Modifications in extracellular Mg 2 affected ACh-evoked 45Ca2 influx, efflux and intracellular free C a2+ mobilisation. Elevated extracellular Mg2+ …
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Uniform biodegradable microparticle systems for protein delivery
Therapeutic protein drugs are receiving increasing attention in pharmaceutical industry due to the fast development of biotechnology and genomics. Because of their low oral and transdermal bioavailabilities, fragility and short half-lives in vivo, novel and effective alternatives to deliver protein …
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Exploring the bidirectional interface between stress and innate immunity: a focus on glucocorticoid and TLR4-MyD88 signalling
… molecular pattern (DAMP)-related protein release. Here, a low concentration of corticosterone increased ATP-induced BV2 cell motility. Signalling via GR, a stress-like concentration of Corticosterone and Dexamethasone caused an increase in cytotoxicity and HMGB1 DAMP protein …
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Biopolymer and Cation Release in Aerobic and Anaerobic Digestion and the Consequent Impact on Sludge Dewatering and Conditioning Properties
… from the perspective of biopolymer and cation release from activated sludge flocs. Both aerobic and anaerobic digestion processes were considered from two different activated sludge sources at a temperature of 20° C. Polymer demand and specific resistance to filtration increased with an …
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Uniform double wall microspheres/microcapsules for protein delivery
… delivery of small molecule drugs as well as proteins and DNA. The size distribution of protein-loaded biodegradable polymer microparticle is a crucial factor for allowable routes of administration. Also, the geometric structures of microparticles can influence the resulted release profile. In …
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Biodegradable in situ forming photocrosslinked implants for sustained protein delivery to the posterior segment of the eye
… degeneration and diabetic retinopathy - are proteins. <br/><br/>This thesis shows the capacity of in situ forming implants, formed from gels that can be injected through needles suitable for intravitreal injection, to provide sustained protein release for several months, with high daily …
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The ultrastructural morphology of Eimeria tenella exhibits striking natural variation and undergoes significant changes during the first few hours of infection
… similarity with that of intrinsically disordered protein-containing droplet organelles; this comparison may help to direct future research into the character and function of these mysterious organelles. In an adjacent project, the organelle numbers and volumes for the E. tenella sporozoite stage …
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Recombinant collagen production optimization in Escherichia coli
… step for E. coli disruption and endogenous protein release..
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Tissue engineering of co-cultured skin substitutes using biocomposite membranes based on collagen and polycaprolactone
… by solvent evaporation. In vitro assays of total protein release of collagen:PCL and gelatin: PCL biocomposite films revealed an expected inverse relationship between the collagen release rate and the content of synthetic polymer in the biocomposite samples that may be exploited for controlled …
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Studies investigating the preparation of solid core drug delivery systems for oral delivery of y-globulin via supercritical fluid processing technology
The rising interest in protein therapeutics has led to the growing research in the development of novel carrier systems particularly for oral delivery. However, several physicochemical and biological barriers pose as a challenge for the use of biomolecules as oral drug therapies. Solid core drug …
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Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD
… granules, generate reactive oxygen species and release neutrophil extracellular traps (NETs). However, these anti-microbial strategies can also cause substantial bystander tissue injury. Infected and inflamed tissues are profoundly hypoxic, and this oxygen depletion both compromises …
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Self-assembled thin films with tunable release kinetics for biomedical applications
… regards to the types of drugs as well as their release kinetics, especially if more than one drug is involved. Furthermore, for implantable devices biocompatibility and biodegradability are important considerations for minimizing undesirable side effects. This thesis utilizes the layer-by-layer …
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Second Generation Photoactivated Insulins
… for a continuously variable light stimulated release of insulin. In this approach, a protein depot that can last for days is injected under the skin. A light source placed on the skin above the site of injection can trigger protein release into the blood with a transcutaneous irradiation. …
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Protein Thermal Stabilization and Delivery via Adsorption onto Porous Silicas
… to failures in temperature control logistics. Proteins, the main components of vaccines, enzymes and many pharmaceuticals, are sensitive to denaturing and losing their conformational structure when exposed to thermal stress. This is why most pharmaceutical products require a …
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The Role of Phase Inversion in the Drug Release Kinetics of Injectable Polymer Solutions
… nonsolvent induced phase inversion plays in the protein release kinetics of injectable drug delivery devices are presented. In situ optical techniques coupled with scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC) were used to examine the relationship between …
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Studies into solid core drug delivery system using haemoglobin as a model drug and supercritical fluid processing for encapsulation
… core drug delivery system for oral delivery of proteins using silica as core material, haemoglobin as model drug and supercritical fluid processing as encapsulation technique. Silica particles of different morphology were used as a carrier material for protein immobilisation and fatty acids …
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