Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"protein regulation"”.
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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION
Cellular protein homeostasis is achieved by a delicate network of molecular chaperones and various proteolytic processes such as ubiquitin–proteasome system (UPS) to avoid a build-up of misfolded protein aggregates. The latter is a common denominator of neurodegeneration. Neurons are found to be …
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Dietary Protein Regulation of Insulin Sensitivity and Glucose Homeostasis
Taken together, these data suggest that HPD, high in leucine, modifies glycemic control by reducing the regulatory role of insulin and peripheral disposal of dietary CHO and upregulating hepatic gluconeogenesis under fasted conditions.
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Toll-Interacting Protein Regulation of Low-grade Non-resolving Inflammation
… modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor molecules in Toll-like receptor 4 (TLR4) signaling and potentially playing key roles in modulating the dynamic adaptation of innate leukocytes to varying dosages of external stimulants. While Tollip …
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The P22 Xis Protein: Regulation of Bacteriophage P22 Site -Specific Recombination
Mutants of P22 Xis were isolated and assayed for excision system in vivo, to quantify their excision activity relative to wild-type Xis. Mutants S18F, R19A, G29S, G29D, A33P, R35C, D37G, S43F, S43P, P44L, L46F, A51T, and A51V were found to be defective in stimulating excision. Additionally, …
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Structural Determinants of Post-transcriptional Protein Regulation as Modulators of Monoamine Signaling
… made in describing the function and endogenous regulation of these systems, as well as their response to pharmacological intervention. However, many aspects of these systems remain unexplored. For example, though the role of pharmacological agents in regulating monoamine transporter function has …
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Molecular analysis of small RNA and small protein regulation of Escherichia coli stress responses
… act as mRNAs themselves by encoding functional proteins. This study examines the regulatory and physiological effects of both a non-coding sRNA, DicF, and the protein product of a dual-function sRNA, SgrS in Eschericha coli. The sRNA SgrS encodes the small 43-amino acid protein SgrT. Both …
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Protein regulation in Trichodesmium and other marine bacteria: observational and interpretive biomarkers of biogeochemical processes
… can focus on benchmarking and calibration of the protein biomarkers identified here, as well as continued connection of systems biology frameworks to the study of ocean chemistry.
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The effect of oral glutamine supplementation on gut permeability and heat shock protein regulation in runners with a history of gastrointestinal distress
… reduces exercise induced permeability through up-regulation of the heat shock response resulting in occludin stabilization, and (2) depresses the exercise induced inflammatory response. Methods. Eight human subjects (n=8) participated in baseline (PRE) testing, a glutamine (GLN), and placebo (PLA) …
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Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia
… Previous investigations have revealed upregulation of contractile receptors, a putative factor in the blood flow reduction following stroke that can could augment cell death. The major aim of the study is achieve a better understanding of the changes that occur in the cerebral arteries …
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Molecular recognition in plant immunity
… disease-resistance genes, which generally encode proteins with nucleotide-binding and leucine-rich repeat domains (NB-LRRs). NB-LRRs are a large of proteins found in both plants and animals, with plant NB-LRRs further classified by the presence of N-terminal coiled-coil or toll-interleukin …
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Comprehensive definition of Ser/Thr/Tyr phosphorylation in mycobacteria: towards understanding reprogramming of normal macrophage function by pathogenic mycobacteria
… it employs to adapt and survive. We investigated protein regulation by the process of phosphorylation, through sensory kinases, which add a phosphate group to a protein of interest, thereby regulating its function. First, we interrogated the phosphoproteomic landscape between M. bovis BCG and M. …
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Motility and Force Generation Based on the Dynamics of Actin Gels
… force and motility is regulated by actin binding proteins and the mesoscopic shape of the gel. Here we controlled an analyzed the effect of both, protein regulation and gel morphology by an in-vitro medium consisting of pu-rified proteins and biomimetic beads with a nucleating surface. Under the …
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A genetic platform for the study of protein perturbation and prion-based inheritance
Proteins mediate every cellular process. In order for life to exist, each protein must be finely tuned to carry out its function at the proper time and place. Because the environment is dynamic and often unpredictable, the regulation of proteins must be responsive to environmental stimuli. …
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Ceramide-Induced Alternative Translocation of TM4SF20
The polytopic membrane protein TM4SF20 (transmembrane 4 L6 family 20) is a protein containing four transmembrane helices that inhibits the Regulated Intramembrane Proteolysis (RIP) of the transcriptional factor CREB3L1 (cAMP response element binding protein 3-like 1), a transcription factor …
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Transcriptomic analysis of the response of the lactic acid bacteria Lactococcus piscium for the identification of possible adaptive genes during thermal shock in cold and warm temperatures
… of 0 °C and 28 °C was conducted. The data of protein regulation during the experiment shows that Lactococcus piscium has the essential machinery to survive against different types of environmental stress. I observed known heat shock related genes and stress related genes to be present in the …
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A Study Of Novel Activities Of Type Iii Sirtuins: Cobb And Pfsir2A
… lysine residues is an accepted paradigm for gene regulation in eukaryotes. In recent years, proteonomic studies revealed that many cellular proteins are acetylated and are regulated by post translational modifications. Although initially, sirtuins gained notoriety when Sir2 yeast was discovered to …
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Gene expression changes during mammalian male meiotic initiation
… for housekeeping processes, including mRNA and protein regulation. Both upregulated and downregulated genes were expressed throughout the time course, but their expression levels were modulated at meiotic initiation. By performing motif enrichment analysis at the proximal promoters, we …
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The Art of Modeling and Simulation of Multiscale Biochemical Systems
… decaying dimerization model and a heat shock protein regulation model.
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Neuronal and Molecular Adaptations of GABA Neurons in the Ventral Tegmental Area to Chronic Alcohol
… we analyzed the GJ mediated coupling and protein regulation of VTA GABA neurons following a three week period of continuous ethanol exposure via liquid diet. Although some animals showed tolerance, there was no significant tolerance to ethanol inhibition of GJ-mediated electrical coupling. …
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