Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 105 for “"protein quality"”.
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The Systems Biology of the Protein Quality Control
… protease, is the main powerhouse for protein degradation in all eukaryotic cells. Proteostasis is maintained by the ubiquitin-proteasome system (UPS) targeting aberrant proteins whose accumulation and aggregation are hallmarks of aging and neurodegenerative disorders. Previous studies …
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Protein quality control processes in the yeast golgi
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Protein quality control in the mammalian endoplasmic reticulum
Quality control is an important part of protein biogenesis. Aberrant proteins must be destroyed before they aggregate and cause deleterious effects. Failure to do so can result in cell death or malfunction and, ultimately, disease. Quality control involves the recognition of misfolded proteins and …
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DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… have a rapid turnover and impair of gap junction quality control impacts cell-to-cell communication; resulting in electrical conduction abnormalities and arrhythmogenesis. Therefore, understanding the underlying mechanism the quality control of mitochondria and gap junctions profoundly contributes …
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Effect of processing on the protein quality of wheat germ
LD2668 .T4 1967 A5
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Effect of processing on the protein quality of wheat germ
LD2668 .T4 1967 A5
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Methods to Evaluate Protein Quality of Diets for Lactating Cows
… between three systems for evaluating dietary protein quality for lactating cows: a) milk protein score (MPS); b) Cornell Net Carbohydrate and Protein System (CNCPS); and c) supplying methionine (Met) and lysine (Lys) as 5 and 15% of the predicted total essential amino acids in duodenal …
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Investigating dysregulation in protein quality control mechanisms in senescent cells
… pathways and mechanisms which protect cellular protein homeostasis, including synthesis, folding, trafficking and degradation of proteins. Proteostasis loss is implicated in both normal ageing and diseases of ageing in humans, although which mechanisms are disrupted and how is currently unclear. …
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The Phase Behavior of Ubqln Proteins and Implications for Protein Quality Control
… autophagy are essential pathways for maintaining protein quality control (PQC) in cells. Misfolded proteins and large aggregates are cleared by UPS and autophagy signaled by ubiquitin (Ub) or polyubiquitin (polyUb) chains. Shuttle proteins facilitate cargo transporting by interacting with both …
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Protein quality and distribution determines anabolic signaling, cellular energetics, and body composition
… and maintaining muscle is critical to the quality of life for adults and elderly. Physical activity and nutrition are important factors for long-term muscle health. In particular, dietary protein – including protein distribution and quality – are under-appreciated determinants of muscle …
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Effects of protein sources and processing conditions on protein quality in canine nutrition
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii
… small-molecule drugs, recombinant therapeutic proteins offer advantages like enhanced specificity and reduced side effects, and there has been tremendous growth in their innovation thanks to modern DNA technologies and AI-driven algorithms. While mammalian platforms such as Chinese Hamster …
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Redox Sensing By Yeast Hsp70 Facilitates Modulation of Protein Quality Control and The Cytoprotective Response
… of these aggregates is damage sustained to proteins by oxidative stress. Cellular protein homeostasis (proteostasis) relies on the ubiquitous Hsp70 chaperone family. Hsp70 activity has been previously shown to be modulated by modification of two key cysteines in the ATPase domain by …
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Effect of processing methods and raw material sources on protein quality of animal protein meals
… systems/temperature and raw material source on protein quality of five feather meals (FM), 32 meat and bone meals (MBM) and 12 poultry by-product meals (PBPM) using digestibility and chick growth assays. True digestibility of amino acids (AA) was influenced by raw material source and type of …
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Investigating the protein quality control pathways that prevent protein aggregation in the social amoeba Dictyostelium discoideum
… hallmark of many neurodegenerative diseases is protein aggregation. Protein aggregation occurs in part due to failure of protein quality control pathways. A better understanding of these pathways could allow us to improve therapies to help control protein aggregation. Here, I investigated …
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Protein quality and digestibility of whole wheat as affected by drum-drying and single screw extrusion processing
… drum-drying and thermoplastic extrusion, on protein quality and digestibility of whole wheat. Coker 916 whole wheat flour was made into a simulated whole wheat spaghetti by extrusion cooking (single screw, 50 psi, 93°C) and a flaked product by drum-drying (152°C). Protein Efficiency Ratios …
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Evaluation of Factors Affecting Protein Quality as Well as Lysine and Sulfur Amino Acid Bioavailability of Commercial Enteral Products
Rat bioassays were conducted to evaluate protein quality as well as lysine (LYS) and sulfur amino acid (SAA) bioavailability in three commercial enteral products as affected by the severity of heat processing during sterilization, carbohydrate composition and storage of the products for 1 year. …
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Degradation of the E. coli small heat-shock proteins by the AAA+ protease lon : significance to protein quality-control
… and elimination of damaged and aggregated proteins requires the concerted effort of several branches of the protein quality-control network. This network includes refolding chaperones, disaggregases, holdases and proteases. Many years of investigation have led to a partial understanding of …
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