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Showing 1 to 14 of 14 for “"protein prenylation"”.
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Characterization Of Protein Prenyltransferases And Protein Prenylation In Plasmodium Falciparum
… urgent to identify new drug targets. Many proteins involved in eukaryotic signal transduction and cell cycle progression undergo post-translational lipid modification by a prenyl group. Protein prenyltransferases, which catalyze the post-translational prenyl modification, have been …
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Studies and applications of protein prenylation using isoprenoid analogues and site-directed mutagenesis
The site-specific enzymatic modification of proteins offers a powerful tool both for the development of new research techniques and for the development of more effective therapeutics. Protein farnesyltransferase (PFTase) is a promising tool in the field of site-specific protein modification due to …
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The Role of High-Density Lipoproteins and Related Pathways in Alzheimer’s Disease
… that high plasma levels of high-density lipoprotein (HDL) protect against cardiovascular disease and accumulating evidence indicates that the beneficial role of HDL extends to the central nervous system. There are several important biological mechanisms that regulate HDL generation and …
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Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation
… 4, we further explored the mechanistic role of protein prenylation in the regulation of eTreg cells by performing a comprehensive analysis of protein prenylation-dependent molecular signaling in eTreg-cells. Specifically, we found that Fntb drives eTreg-cell maintenance by promoting mTORC1 …
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Investigating the role of zoledronate for inhibition of osteosarcoma metastasis
… rearrangement largely controlled by Rho GTPase proteins (RhoA, RhoC, Rac-1 and Cdc42) and effector pathways (Rho-kinase; ROCK). Given their pivotal role in directional cell migration, perturbing the function of Rho GTPases is considered a viable anti-metastasis strategy. Disruption of Rho GTPase …
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Prenylation in cell-intrinsic innate immunity to positive-strand RNA viruses
… the impact organelle membrane targeting through protein prenylation has on the antiviral specificity of innate immune RNA binding proteins in the context of positive-strand RNA virus infection. Since positive-strand RNA viruses use host organelle membranes to construct niches for RNA replication, …
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Prognostic Markers and Mechanisms of Chemotherapy Resistance in Diffuse Large B-cell Lymphoma
… patients. A study about the effect of inhibited protein prenylation on the response to CHOP therapy, using an in vitro cell-line-based model, showed that treatment with geranylgeranylation inhibitors in DLBCL cell lines had a chemo-sensitising effect. This indicates that inhibition of …
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EXPANDING THE POTENTIAL PRENYLOME: PRENYLATION OF SHORTENED TARGET SUBSTRATES BY FTASE AND DEVELOPMENT OF FRET-BASED SYSTEM FOR DETECTING POTENTIALLY “SHUNTED” PROTEINS
<p>Protein prenylation is a posttranslational modification involving the attachment of a C15 or C20 isoprenoid group to a cysteine residue near the C-terminus of the target substrate by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase type I (GGTase-I), respectively. Both of …
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Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
… neuronal processes. Both RhoA and Rac1 require prenylation for membrane targeting, which is believed to be required for activation of these GTPases via interaction with GEFs. Meta-analyses in the early 2000's showed that people who took statins, global inhibitors of protein prenylation, have …
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Islet Dysfunction In Diabetes
… under these conditions. Post-translational prenylation of lamins is important for their localization into the nuclear membrane, and subsequent interaction with other proteins. Our results indicate that inhibition of prenylation by simvastatin and a site-specific inhibitor of protein …
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Structure-Guided Development of Antifungal Protein Farnesyltransferase Inhibitors and DNA Polymerase Engineering
… Therefore, there is a need for new therapeutics. Protein prenylation catalyzed by protein farnesyltransferase (FTase) and protein geranylgeranyltransferase (GGTase) is essential to the survival of Cryptococcus neoformans, Candida albicans, and Plasmodium falciparum. The previous biophysical and …
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Biochemical and structural characterization of radical SAM enzymes Elp3 and viperin
… The eukaryotic Elongator complex is a large protein complex consisting of six Elongator proteins (Elp1-Elp6) and has been associated with several cellular processes and neurological diseases in humans. Of the six subunits, Elp3 is considered the catalytic subunit with two putative enzymatic …
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ISPH fusion proteins, ISPH inhibition, and bisphosphonate mechanism of action
… of bacterial IspH we called IspH-RPS1, a fusion protein of IspH with ribosomal protein S1 (RPS1), was characterized. Next, a new class of IspH inhibitors, one without diphosphate groups, was discovered. The characterization of an IspH-RPS1 began with a bioinformatics analysis of the IspH protein …
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Attempted Synthesis of a Photoreactive Geranylcysteine Derivative.
… to be studied as a mimic for farnesylated protein, <b>B</b>, the following syntheses were carried out. The hydroxyl group of geraniol was protected with DHP/PPTs to generate <b>1</b> (98.1%). Allylic oxidation of <b>1</b> by using TBHP/SeO2 yielded <b>2</b> (31.5%). A modified oxidation …