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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"protein phosphatases"”.
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Structure/function studies of protein phosphatases
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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Protein phosphatases and protein kinases in dictyostelium
… behavior and partial characterization of 5 protein phosphatases, 6 paranitrophenyl phosphate (pnpp) phosphatases and 2 protein kinases from <i>Dictyostelium</i> are described. .Two of the protein phosphatases are shown to have subunit structures. All of the protein phosphatase activities …
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Dual-specific protein phosphatases in the <i>Archaea</i>
… sequence similarity among the three families of phosphatases. All known LMW PTP remove phosphoryl groups esterified to the hydroxyl amino acid: tyrosine, whereas all members of the Cdc25 family are dual-specificity protein phosphatases that dephosphorylate all the hydroxyl amino acids: tyrosine, …
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Investigations into the role of protein phosphatases in the EGFR signaling network
Protein phosphatases regulate the phosphorylation state of intracellular signaling molecules in conjunction with protein kinases. In order to better understand the role of phosphatases in the ErbB signaling network, experimental studies were carried out to validate assays and phosphatase inhibitors …
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The Role of Protein Phosphatases in Regulation of Drosophila S6 Kinase by Nutrient Signaling Pathways
… to environmental signals. As many of the protein components of nutrient signaling pathways are proto-oncogenes, of equal importance is identifying and characterizing the components utilized to down-regulate growth, as mutations in these genes may also lead to genesis of disease. Protein …
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Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway
Reversible protein phosphorylation is a highly conserved mechanism that regulates the majority of proteins in a eukaryotic cell. Protein phosphorylation has been implicated in various cellular processes including glycogen metabolism, cell cycle control, RNA splicing, DNA synthesis, muscle …
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Attenuated Responses To Inflammatory Cytokines In Mouse Embryonic Stem Cells: Biological Implications And The Molecular Basis
… viability. Furthermore, basal expressions of protein phosphatases that inhibit IFNg pathway were higher in mESCs than mESC-FBs. Treating mESCs with protein phosphatases inhibitor upregulated the expression of IFNg induced signaling molecule. In all, the attenuated inflammatory responses are …
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Protein phosphorylation regulation in Arabidopsis
… THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Protein phosphorylation and dephosphorylation are fundamental mechanisms involved in many cell-signaling events. Coordinated actions of protein kinases and protein phosphatases help maintain the signaling through reversible protein phosphorylation …
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Molecular Characterization of Dopamine Transporter Phosphorylation and Regulation
… (DAT) is a presynaptic membrane phosphoprotein that terminates dopaminergic synaptic transmission by clearing dopamine (DA) back into presynaptic neuron by a reuptake process. DAT is also a molecular target for psychostimulants such as cocaine, amphetamine (AMPH) and methamphetamine …
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Small Phosphomonoesters as Probes of Protein-Tyrosine Phosphatase Active Sites
… for differentiating between two families of protein phosphatases: the protein-tyrosine phosphatases [PTPs] and the dual-specificity protein phosphatases [DSPs]. Three PTPs, PTP-1B, Tc-PTPa, and PTP-H1, and three DSPs, Cdc-14, VHR, and IphP, were challenged in vitro with alpha-naphthyl …
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Toxicity of microcystin-LR in hepatocytes and non-hepatocytes in vitro
… a cyanobacterial heptapeptide is an inhibitor of protein phosphatases 1 and 2A (PPs), a potential tumor promoter in rat liver, and selectively toxic to the liver in vivo and isolated hepatocytes in vitro. Inhibition of PPs has been linked to excessive phosphorylation and collapse of intermediate …
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Protein Phosphatase 4 in human spermatozoa: investigations into location, regulatory subunits and role in motility
… in the regulation of sperm motility implies that protein phosphatases may be involved. The results presented in this thesis are the results of investigations into the role of serine/threonine protein phosphatases in human spermatozoa. It was hypothesised that the catalytic subunit of PPP4 would be …
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The Enantiospecific Total Syntheses of Adda and Nodularin
… development of SAR studies to elucidate roles of protein phosphatases in tumor promotion or suppression.
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Mechanisms of microcystin-LR toxicity
… hepatotoxin that inhibits serine/threonine protein phosphatases types 1 and 2A in hepatocytes in vivo and in vitro, and disrupts actin microfilament (MF), microtubule (MT) and intermediate filament (IF) networks. The sequential ultrastructural and biochemical changes induced by MCLR were …
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Development Of Kinase Catalyzed Biotinylation To Study Phosphoproteomics
<p>Kinase-catalyzed protein phosphorylation is involved in a wide variety of cellular events. Development of methods to identify phosphoproteins in normal and diseased states is critical to fully characterize cell biology. Our lab recently discovered kinase-catalyzed biotinylation, where ATP-biotin …
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Identification and characterization of signal components in early ABA signaling in Arabidopsis
… receptors PYRABACTIN RESISTANCE 1 and PYR1-Like protein (PYR1/PYLs), type 2C protein phosphatases (PP2Cs) and SNF1- related protein Kinase 2s (SnRK2s). In the presence of ABA, PYR1/PYLs bind to and inhibit PP2Cs, leading to the release of SnRK2s from suppression, to activate downstream events …
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Towards the synthesis of novel protein phosphatase inhibitors
Protein phosphatases (PPases) are important enzymes which mediate dephosphorylation of proteins in eukaryotic cells. These enzymes are involved in a variety of cellular processes, and disruption of their activity has been shown to be involved in the development of diseases such as cancers and …
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The Development of Photo-crosslinkable Trapping Mutants as Tools to Investigate the Interactions of Protein Tyrosine Phosphatases
Abnormalities in the coordinated activities of protein phosphatases (PPs) and<br/>protein kinases (PKs) contribute to the development of many diseases.<br/>Phosphatase of regenerating liver (PRL)-3 and Vaccinia H1-Related (VHR) are<br/>two members of the protein tyrosine phosphatase (PTP) family …
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Regulatory network built by Cytochrome c with Histone Chaperones in response to DNA damage
… activation, this network is tightly regulated by protein phosphatases, such as Protein Phosphatase 2A (PP2A). Moreover, histone chaperones assist the DNA repair mechanisms altering chromatin dynamics through their nucleosome assembly activity. Recent studies have reported that the mitochondrial …
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