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Showing 1 to 20 of 31 for “"protein phosphatase 2A"”.
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Characterization of the Protein Phosphatase 2A Regulatory Subunit PR70
Protein phosphatase 2A (PP2A) is a phosphoserine/threonine phosphatase that controls the phosphorylation of numerous proteins in eukaryotic cells. PP2A consists of a core dimer composed of a scaffolding subunit (A-subunit) and a catalytic subunit (C-subunit) that interacts with a variety of …
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Identification and characterization of protein phosphatase 2A mutants in Arabidopsis thaliana
<p>Reversible protein phosphorylation is a highly regulated process that affects almost all cellular activities. Phosphorylation involves two groups of enzymes: protein kinases and protein phosphatases. Considering the central role of these enzymes in cells, elucidating their function is extremely …
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Association of Protein Phosphatase 2A with S6 Kinase Is Regulated In an MTOR-Dependent Manner
… senses nutrient and growth factors to regulate protein synthesis and cell growth. Strict control of the components of this pathway is essential for cells to reach an appropriate size. Aberrant mTOR signaling has been implicated in multiple diseases such as cancer, diabetes, and heart failure. …
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Role of Protein Phosphatase-2A in Regulating Monocyte Activation by Soluble and Crystalline Uric Acid in Gout
… and conversion of pro-IL-1β to active IL-1β. Protein-phosphatase-2A (PP2A) is a serine/threonine phosphatase that plays an important role in cell growth and inflammation. The prodrug Fingolimod (FTY720) and its phosphorylated active metabolite (p-FTY720) activate intracellular PP2A. We …
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Protein Phosphatase 2A Function in Response to Salt Stress in Arabidopsis thaliana: Defining Pathways and Genetic Interaction Networks
<p>Protein phosphatase 2A (PP2A) is a key regulator of many biological pathways. The PP2A heterotrimer is composed of a scaffolding/regulatory A subunit, regulatory B subunit, and catalytic C subunit. In Arabidopsis thaliana, the A, B and C subunits are encoded by 3, 17, and 5 genes, respectively. …
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Angiotensin Type-2 (At2) Receptor Modulation of Nmda-Mediated Current, Signaling and Apoptosis
… primarily through AT2 receptor activation of the protein phosphatase 2A (PP2A), attenuated NMDA-mediated increases in extracellular regulated kinase-2 (ERK-2) activity. We have identified that AT2 receptor activation inhibits cleavage of the DNA repair enzyme poly-(ADP-ribose) polymerase (PARP) …
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REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK/ERK IN CELL DYNAMICS
… regulation of RhoA. A serine-rich multi-domain protein, DLC1 undergoes post-translational modifications such as phosphorylation. It has been identified as a downstream target for various kinases but effects of growth factors, which play a crucial role in the development and progression of …
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Analisi Molecolare del Melanoma
… comparative proteomic analysis revealed that six proteins were overexpressed in both melanoma cell lines as compared with melanocytes: galectin-1, inosine-5'-monophosphate dehydrogenase 2, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A ¿ isoform, protein DJ-1, cyclophilin A …
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Regulatory network built by Cytochrome c with Histone Chaperones in response to DNA damage
… activation, this network is tightly regulated by protein phosphatases, such as Protein Phosphatase 2A (PP2A). Moreover, histone chaperones assist the DNA repair mechanisms altering chromatin dynamics through their nucleosome assembly activity. Recent studies have reported that the mitochondrial …
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Dysregulated ERK signal pathway and immune profiles in Fragile X Syndrome
… production of the Fragile X Mental Retardation Protein (FMRP) leads to changes in dendritic morphology and resultant cognitive and behavioral manifestations characteristic of individuals with FXS. FMRP is an RNA-binding protein that is believed to regulate the translation of a large number of …
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Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae
… manipulation, gene knock outs, plasmid based protein expression, and <em>in vivo</em> protein localization of fluorescence tagged proteins was employed to determine the function of an essential protein, Lst8, in TORC1 and TORC2 signaling and a previously uncharacterized complex, the …
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AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication
… B형 간염 환자는 간경변이나 간암으로 발전할 가능성이 높다. AMP-activated protein kinase(AMPK)는 ATP 소비와 생성의 균형을 위해서 필요한 에너지 센서 단백질이다. Hepatitis C virus(HCV)의 증식을 위해서는 AMPK의 억제와mammalian target of rapamycin(mTOR)의 활성이 필요하며 이를 통해 바이러스 복제에 필요한 지질을 합성한다. HBV X 단백질(HBx)은 mTOR의 활성을 증가시켜 hepatocellular carcinoma(HCC) 세포의 증식을 …
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An interdisciplinary study of the mechanical and dynamic properties of α-solenoid repeat proteins
Tandem-repeat proteins differ from globular proteins, both in their biophysical characteristics and in how they interact with their respective partners, yet they comprise nearly one third of the human proteome and are central to many cellular processes and disease phenotypes. Repeat proteins have …
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Structure-function Analysis of the STRIPAK Complex
… critical aspects of biology. Kinases and phosphatases interact not only with their substrates but also with regulatory subunits and scaffolds. In recent years, affinity purification coupled to mass spectrometry (AP-MS) has proven to be a powerful tool to identify protein-protein …
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Regulation of Mitotic Spindle Assembly in Caenorhabditis elegans Embryos
… little is known about their counteracting phosphatases. A screen for genes required for early embryonic cell divisions in C. elegans identified rsa-1 (for regulator of spindle assembly 1), a putative Protein Phosphatase 2A (PP2A) regulatory subunit whose silencing causes defects in spindle …
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p38 MAPK Signalling in Endothelial Apoptosis
… ocurris through an increased activatity of the protein phosphatase 2A (PP2A). In addition to pharmacological inhibition, we used lentiviral vector transfection of EA.hy926 cells to express a dominant negative mutant Flag-p38 MAPK harboring T180A and Y182 F amino acid substitutions. Similarly to …
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PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis
… species (ROS) that activate NLRP3 inflammasome. Protein phosphatase-2A (PP2A) may be involved in regulating inflammatory pathways in macrophages. Proteoglycan 4 (PRG4) and its receptor CD44 and its transducer PP2A signaling axis play a biologically significant role in regulating urate crystal …
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The Role of Protein Phosphatases in Regulation of Drosophila S6 Kinase by Nutrient Signaling Pathways
… to environmental signals. As many of the protein components of nutrient signaling pathways are proto-oncogenes, of equal importance is identifying and characterizing the components utilized to down-regulate growth, as mutations in these genes may also lead to genesis of disease. Protein …
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Signaling Mechanisms That Control Gap Junctional Coupling Between Retinal Neurons
… connexin 35) is the major neuronal gap junction protein in the central nervous system (CNS), and contributes to several important neuronal functions including neuronal synchronization, signal averaging, network oscillations, and motor learning. Connexin 36 is strongly expressed in the retina, …
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Genomic approaches to understand sweetpotato root development in relation to abiotic factors
… 52,322 (69.55%) of these unigenes matched to a protein sequence from UniprotKB. Data from de novo root transcriptome enriched the existing sweetpotato gene index by 37,697 new sequences. Genes which control storage root formation under normal and drought and salt stress conditions were …
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