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Showing 1 to 20 of 125 for “"protein phosphatase"”.
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Towards the synthesis of novel protein phosphatase inhibitors
Protein phosphatases (PPases) are important enzymes which mediate dephosphorylation of proteins in eukaryotic cells. These enzymes are involved in a variety of cellular processes, and disruption of their activity has been shown to be involved in the development of diseases such as cancers and …
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Characterization of the Protein Phosphatase 2A Regulatory Subunit PR70
Protein phosphatase 2A (PP2A) is a phosphoserine/threonine phosphatase that controls the phosphorylation of numerous proteins in eukaryotic cells. PP2A consists of a core dimer composed of a scaffolding subunit (A-subunit) and a catalytic subunit (C-subunit) that interacts with a variety of …
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Protein Phosphatase 1 at the Kinetochore Regulates Chromosome Segregation
… and kinetochore kinases, including Aurora B. Protein Phosphatase 1 (PP1) plays a counteracting role to Aurora B to stabilize kinetochore-microtubule attachments and silence the SAC. The regulation of PP1 to modulate these functions, however, remains enigmatic. Using the biochemical tools …
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Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory
Protein phosphatase inhibitor-1 and cyclin-dependent kinase 5 (Cdk5) have been independently implicated in synaptic plasticity, learning, and memory. We began our studies with the identification, confirmation, and characterization of a novel Cdk5-dependent phosphorylation site (Ser6) on …
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Identification and characterization of protein phosphatase 2A mutants in Arabidopsis thaliana
<p>Reversible protein phosphorylation is a highly regulated process that affects almost all cellular activities. Phosphorylation involves two groups of enzymes: protein kinases and protein phosphatases. Considering the central role of these enzymes in cells, elucidating their function is extremely …
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Characterization of the specificity and functions of the protein phosphatase Cdc14
<p>Protein phosphorylation is perhaps the most ubiquitous posttranslational modification in eukaryotes and recent studies suggest that upwards of 75% of human proteins are phosphorylated. Many proteins are phosphorylated at multiple sites, often controlled by multiple kinases and phosphatases. …
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Association of Protein Phosphatase 2A with S6 Kinase Is Regulated In an MTOR-Dependent Manner
… senses nutrient and growth factors to regulate protein synthesis and cell growth. Strict control of the components of this pathway is essential for cells to reach an appropriate size. Aberrant mTOR signaling has been implicated in multiple diseases such as cancer, diabetes, and heart failure. …
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The regulation of chromosome segregation by Aurora kinase, protein phosphatase 1 and nucleolar protein UTp7
… during anaphase is regulated by the Cdc14 protein phosphatase, which is kept inactive in the nucleolus until anaphase onset. I show here that the predominantly nucleolar ribosome biogenesis protein Utp7 is also present at kinetochores and is required for normal organization of kinetochore …
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Protein Phosphatase 4 in human spermatozoa: investigations into location, regulatory subunits and role in motility
… in the regulation of sperm motility implies that protein phosphatases may be involved. The results presented in this thesis are the results of investigations into the role of serine/threonine protein phosphatases in human spermatozoa. It was hypothesised that the catalytic subunit of PPP4 would be …
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An Approach to the Total Synthesis of the Protein Phosphatase 1 and 2A Inhibitor Microcystin -Lr
The present study is an investigation of different synthetic routes to the natural product utilizing several protecting group strategies. Extensive studies were required to gain insight into the susceptibility of the intermediates to reaction conditions. This work has led to the first synthetic …
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Novel roles of striatal enriched protein phosphatase (STEP) in neuronal intrinsic properties and homeostatic synaptic plasticity
STriatal Enrich Protein Phosphatase (STEP) is a brain specific protein tyrosine phosphatase, which is only expressed in the central nervous system (CNS). STEP has two major isoforms, including STEP46 and STEP61 and membrane-bound STEP61 is implicated in multiple neurologic disorders. For example, …
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Role of Protein Phosphatase-2A in Regulating Monocyte Activation by Soluble and Crystalline Uric Acid in Gout
… and conversion of pro-IL-1β to active IL-1β. Protein-phosphatase-2A (PP2A) is a serine/threonine phosphatase that plays an important role in cell growth and inflammation. The prodrug Fingolimod (FTY720) and its phosphorylated active metabolite (p-FTY720) activate intracellular PP2A. We …
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Protein Phosphatase 2A Function in Response to Salt Stress in Arabidopsis thaliana: Defining Pathways and Genetic Interaction Networks
<p>Protein phosphatase 2A (PP2A) is a key regulator of many biological pathways. The PP2A heterotrimer is composed of a scaffolding/regulatory A subunit, regulatory B subunit, and catalytic C subunit. In Arabidopsis thaliana, the A, B and C subunits are encoded by 3, 17, and 5 genes, respectively. …
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Dual functions of the retinal determination gene network member EYES ABSENT as a transcription factor and protein phosphatase
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.
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Characterization of IphP from Nostoc commune UTEX 584 and a Dual Specificity Protein Phosphatase from Anabaena PCC 7120
Protein phosphorylation is utilized universally as a mechanism of signal transduction. However, the use of tyrosine phosphorylation by bacteria has been a matter of dispute. Conventional wisdom dictated that "prokaryotic phosphorylation" was typified by phosphorylation of histidine and aspartate …
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Purification and characterization of a protein phosphatase (PP1-Arch) from the archaebacterium Sulfolobus solfataricus, isolation and expression of its gene
PP1-Arch was verified as a protein phosphatase by both acid molybdate extraction and thin layer electrophoresis. Soluble fraction was prepared from <i>Sulfolobus solfataricus</i>, from which PP1-Arch was purified over 1OOO-fold by DE-52 ion-exchange, hydroxyapatite, gel filtration (G- 100), and …
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Trichloroacetimidates As Outstanding Electrophiles for the Carbon-nitrogen, Carbon-oxygen and Carbon-carbon Bonds Formation and Synthetic Studies of Protein Phosphatase-5 (pp5) Small Molecule Inhibitors
… studies of small molecule inhibitors for protein phosphatase-5 (PP5) were also undertaken. In recent years, overactivation of PP5 has been linked to the renal cancer and a great need of therapeutic treatment development is necessary. Two previously identified potent inhibitors were …
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Protein phosphorylation regulation in Arabidopsis
… THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Protein phosphorylation and dephosphorylation are fundamental mechanisms involved in many cell-signaling events. Coordinated actions of protein kinases and protein phosphatases help maintain the signaling through reversible protein phosphorylation …
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