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Showing 1 to 5 of 5 for “"protein phase separation"”.
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Maximum Entropy Optimization: a General Approach to Study Ordered and Disordered Proteins Reveals Key Features of Protein Phase Separation
Liquid-liquid phase separation drives the formation of biological condensates that play essential roles in transcriptional regulation and signal sensing. The molecular factors that dictate these condensates' stability and spatial organization are not fully understood, and it remains challenging to …
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Leveraging Protein Homeostasis as a Disease-modifying Strategy
Protein homeostasis (proteostasis) is a fundamental determinant of cellular health, and its impairment is causally linked to a wide range of human diseases. While extensive eHort has gone into characterising how the proteostasis network (PN) maintains proteins in their functional states, more work …
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Programmable Assembly of Elastin-like Polypeptides Within Droplet Microenvironments
<p>Disordered proteins lack a defined secondary and higher order structure, possess a large number of biological functions, and are prevalent throughout nature. One important property of certain disordered proteins in biology is an ability to phase separate within the interior of a cell and form …
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Multiscale coarse-grained models for biological phase separation: Development and applications
Many proteins undergo liquid–liquid phase separation (LLPS) in order to generate membraneless organelles, by which the cell can organise its biomolecules and bioprocesses dynamically in space and time. Many of the experimental and theoretical methodologies used to study the formation of these …
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The interactions of the cucumber mosaic virus 2b protein with the viral 1a and host Argonaute 1 proteins
… cucumber mosaic virus (CMV) 2b multifunctional protein is a suppressor of plant defences and an important determinant of viral pathogenesis. The effect of the 2b protein on symptom induction is due in large part to its physical interaction with the host RNA silencing factor Argonaute 1 (AGO1). …