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Showing 1 to 4 of 4 for “"protein pKa"”.
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A Highly Charged Topic: Intrinsically Disordered Proteins and Protein pKa Values
Intrinsically disordered proteins (IDPs) are known not only for their roles in disease but also for their conformational flexibility, which makes them elusive for experimentation. We consider the role played by theory and simulation in resolving important questions pertaining to IDP structure and …
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Consistent approach for calculating protein pKa's using Poisson-Boltzmann Model
Accurate prediction of protein pKa`s is important to understand protein electrostatics and functions. Improving the accuracy of pKa prediction using the Poisson-Boltzmann electrostatic model remains an active area of research. The major challenge is to determine the appropriate dielectric constant …
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Investigation of Nocifensive and Cellular Effects of Dihydroergotamine in a Model of Chronic Migraine
… inhibit CFA stimulated levels of the signaling protein PKA, which is known to promote central sensitization, and Iba1, a marker of activated microglial cells. However, both DHE and sumatriptan were able to inhibit stimulated levels of GFAP, a protein used as a marker of activated astrocytes. …
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Exploring the role of Leucine Rich Repeat Kinase 2 within the innate immune system
Leucine rich repeat kinase 2 (LRRK2) is a 286 kDa protein expressed in a variety of tissues and cell types, including neuronal tissue and innate immune cells. Mutations in LRRK2 have been linked to inflammatory diseases, most notably Crohn’s disease and Parkinson’s disease. Further to this, LRRK2 …