Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"protein organization"”.
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Structure and Composition of Postsynaptic Densities
… density (PSD), a large electron dense protein complex located just below the synaptic membrane. The PSD, which is composed of signaling, scaffold and cytoskeletal proteins, supports and organizes neurotransmitter receptors within the synaptic membrane in addition to bridging signaling …
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A general method for three color STED microscopy with one depletion laser : application to primary neuronal culture
… extraordinary level of nanoscale spatiotemporal organization of complex and highly dynamic molecular architectures at the pre- and postsynaptic compartments. How exactly these supramolecular complexes are modified through time and experience, though, remains largely unknown. Moreover, the …
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Role of Protein Kinase G in Regulating Vascular Tone in Hypoxic Ovine Cerebral Arteries
… cyclic guanidine monophosphate (cGMP)-dependent protein kinase (PKG) has been shown to be the main mediator of NO-induced vasorelaxation. Less well understood is the behavior of this pathway in conditions of long term hypoxia (LTH). It was later shown that LTH attenuates the ability of PKG to …
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Biological applications of weal polyelectrolyte multilayers
… of cells attached and the amount of cytoskeletal protein organization. The second part is an evaluation of porous polyelectrolyte multilayers as a delivery system for controlled release of small molecule drugs. The loading and releasing properties of porous PAH/PAA multilayers were investigated …
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Depletion of docosahexaenoic acid (DHA) and arachidonic acid causes male infertility by disrupting both secretory granule biogenesis and adherens junction assembly in testis
… the distribution of vesicular trafficking proteins that promote the biogenesis of an organelle unique to sperm, the acrosome. In contrast, ARA was much less effective than DHA in restoring germ cell adhesion integrity. Assessments of cell-cell contacts which form transiently to adhere …
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Single-Objective Tilted Light Sheet Illumination with Exchange-PAINT and Deep Learning for Fast, Accurate, and Precise 3D Single-Molecule Super-Resolution Imaging in Mammalian Cells
… super-resolution imaging of nuclear lamina proteins lamin B1, lamin A/C, and emerin, and the microtubule protein alpha-tubulin. The single-objective dithered light sheet achieves a localization precision below ten nanometers in xy and below 12 nanometers in z, enabling a range of …
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Structure and Organization of Nuclear Pore Proteins
… and the cytoplasm. Elucidating the structure and organization of this complex will be crucial to understanding the mechanism of nucleocytoplasmic transport, but due to its size, the NPC presents a challenge to structure determination. There are electron microscopy (EM) structures of the entire …
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Investigating spatial distribution and dynamics of membrane proteins in polymer-tethered lipid bilayer systems using single molecule-sensitive imaging techniques
… assemblies comprised of lipids and membrane proteins. Both types of membrane constituents are organized in highly dynamic patches with profound impact on membrane functionality, illustrating the functional importance of plasma membrane fluidity. Exemplary, dynamic processes of membrane protein …