Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"protein network"”.
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Structural and Functional Analysis of the Protein Network Controlling Centriole Biogenesis
… of chromosomes. In <i>C. elegans</i>, only five proteins are essential for centriole duplication. How their <i>Drosophila</i> counterparts interact with each other on a molecular level still remains largely unknown. <br></br><br></br> To further our understanding of the protein interactions …
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Discovery of multi-omics biomarkers for toxicity using meta-analysis
… validation of the SMOT genes 21 3-6. GO and protein network analysis of the SMOT genes 22 Ⅲ. RESULTS 23 A. Data preparation & class assignment 23 1. Building of toxicogenomics database using gene expression from integrated studies 23 2. Toxicity class assignments 24 3. Correlations and levels …
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A comparative look at structure-function roles in light-harvesting dynamics of purple bacteria
… near unity quantum efficiency. Light-harvesting proteins transfer energy from the sun to reach a central location, the reaction center, where charge separation occurs and energy is converted to chemical energy. Moreover, these proteins are able to carry out this efficient transfer in cellular …
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Domain-based approaches to understanding phylogeny and orthology
… in this research. Then, the domain complexity of proteins was analysed on a comprehensive basis. Our results showed that bacterial and archaeal proteins are as complex as eukaryotic proteins in domain abundance, but more promiscuous. Proteins emerged in early stage are also more promiscuous, but …
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Small molecule channels increase anion secretion and host defenses in cystic fibrosis airway epithelia: mechanistic studies and initial clinical translation
… this pharmacological approach. In the case of protein ion channel deficiencies, because the endogenous protein network upstream of the missing or dysfunctional channel remains active and may even be upregulated, we hypothesized that ion channel-forming small molecules could harness the …
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Large, noisy, and incomplete : mathematics for modern biology
… thesis discusses two problems in this field, network reconstruction and multiple network alignment, and draws the beginnings of a connection between information theory and population genetics. The first section addresses cellular signaling network inference. A central challenge in systems …
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High-Dimensional Covariate-Dependent Gaussian Graphical Models
… Gaussian graphical model (cdexGGM) for capturing network structure that varies with covariates through a novel parameterization. Utilizing a likelihood framework, our methodology jointly estimates all edge and vertex parameters. We further develop statistical inference procedures to test the …
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Integrating Functional Genomics, Proteomics and Computational Analysis for the Characterization of Cellular Networks
… analysis of functional patterns in biological networks, and also establishing a high throughput experimental platform for the study of signaling pathways. I have developed a generalized method for the analysis of functional organization in complex networks. This method makes use of several …
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Components Required for the Death and Degradation of the Linker Cell in C. Elegans
… functions, in part, through the stressrelated protein HSF-1, and subsequent upregulation of members of the ubiquitin proteasome system. How exactly HSF-1 is post-translationally regulated to either commit to cell survival or cell death is not currently known. Using a protein interaction screen …
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Development of Quantitative Tools for the Characterization and Analysis of the Blood Brain Barrier in Normal and MPS IIIB Mice
… This restrictive nature of the BBB is due to the protein network at the borders of adjoining cerebral endothelial cells known as the tight junctions (TJs) and the relationship of other supporting cells and proteins such as astrocytes, pericytes, microglia, and the basement membrane and …
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Induction and Maintenance of Synaptic Plasticity
… states of a single synapse. The biochemical network involving calcium/calmodulin-dependent protein kinase II (CaMKII) and its regulating protein signaling cascade has been hypothesized to durably maintain the synaptic state in form of a bistable switch. Furthermore, it has been shown …
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Heterogeneous Ultrafast Energy Transfer in Photosynthetic Proteins
… and rapid transport of energy through a protein network to reach the reaction center, where conversion to chemical energy occurs. The energy transport is facilitated through a series of energy transfer events between pigments bound to a protein backbone. These steps exhibit a remarkable …
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Using Persistent Homology for Topological Analysis of Protein Interaction Network of Candida Antarctica Lipase B Molecular Dynamic Simulation Model
… to analyze the conformational changes of the protein and probe its unusual high-temperature activity. Next, we build the protein interaction network of amino acids for CalB to study pairwise interactions between amino acids (nodes) and probe the protein in terms of statistical features of …
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Defining the molecular composition and organisation of Transition fibres in Trypanosoma brucei and their roles in flagellar assembly and length control
… trafficking of intraflagellar transport (IFT) proteins required for flagellar assembly. Transition fibres are present in all ciliated organisms yet only a handful of TF proteins have been identified in mammalian cells. We hypothesise that there are a number of additional components to be …
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Polyphosphoinositide-derived signals in the regulation of vacuole membrane fusion and fission
… system of eukaryotic cells is a dynamic network of membrane-bound organelles that exists in a constant state of flux as they exchange membrane and protein cargoes. The yeast vacuole is a highly dynamic organelle that changes shape in response to both hypo and hyper-osmotic stresses and so …
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Quantitative Modeling of the Molecular Mechanism Controlling the Asymmetric Cell Division Cycle in <i>Caulobacter crescentus</i>
… detailed temporal dynamics of regulatory proteins and corresponding physiological changes during the process of cell cycle progression and differentiation of wild-type cells (both stalked cells and swarmer cells) and of a number of known and novel mutant strains. Our model presents a …
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Unique Emulsions based on recombinant Hydrophobins
Hydrophobins are very interesting proteins of fungal origin. Beside their relatively small size of around 100 amino acids, they are well known to be the most surface active, natural proteins that have a strong tendency for self-assembly. Due to their versatile properties hydrophobins are present in …
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Gene Expression in mESC Deficient in FGFR Signalling and the Identification of the Novel Gene Ened
… building blocks of the basement membrane (BM) protein network. The aim of this thesis was to elucidate the molecular and biological changes occurring due to impaired FGF/FGFR signalling in differentiating EBs. A large scale microarray study was performed that provided insights into the global …
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Characterisation of a novel Rab18 mouse model for Warburg Micro syndrome
… mutations in four members of the RAB protein network; RAB3GAP1, RAB3GAP2, RAB18 and TBC1D20, causing clinically indistinguishable phenotypes. RAB3GAP1 and RAB3GAP2 form a heterodimeric complex specifically regulating the RAB3 family of proteins in calcium mediated exocytosis of …
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Mechanisms of change in protein architecture
Proteins are the basic building blocks and functional units in all living organisms. Moreover, differences between species can frequently be explained with differences in their protein complements. Importantly, proteins are often composed of segments, i.e. domains that have a certain level of …
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