Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"protein nanoparticle"”.
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The rational structure-based design of a protein nanoparticle presenting a chimeric MenB antigen
… to boost immunogenicity. The application of nanoparticles in vaccine formulations has the potential to drive the development of next generation adjuvant systems that improve antigen presentation and overall vaccine immunogenicity.;In addition, advances in structural and computational biology …
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Structure and activity of protein-nanoparticle conjugates: towards a strategy for optimizing the interface
Nanoparticle-protein conjugates have a variety of applications in imaging, sensing, assembly and control. The nanoparticle-protein interface is made of numerous complex interactions between protein side-chains and the nanoparticle surface, which are likely to affect protein structure and compromise …
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Molecular Dynamic Simulation of Bio-molecular Dynamics, Folding, and Assembly
… discuss recent MD simulation studies of RNA, protein-RNA, and protein-nanoparticle interactions with direct comparisons to experiments whenever possible to validate our approaches.
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Single-Molecule and Ensemble Measurements Inform on the Role of Protein Crowding at Interfaces
Surface-adsorbed proteins can critically affect the efficacy of materials designed for biological applications. For example, physiologically relevant quantities of serum albumin stabilize nanoparticles in solution, while decreased protein concentrations induce nanoparticle aggregation. The first …
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THERMOSTABLE EXOSHELLS AS TOOLS FOR RECOMBINANT PROTEIN EXPRESSION AND IN VIVO DELIVERY
We have engineered a thermostable protein nanoparticle (tES) to improve both expression and stabilization of recombinant proteins using a single technology. tES provides steric accommodation and charge complementation to GFPuv, horseradish peroxidase (HRP), and Renilla luciferase, and Photinus …
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Modelling multivalent interactons
A Multivalent entity, which could represent a protein, nanoparticle, polymer, virus or a lipid bilayer, has the ability to form multiple bonds to a substrate. Hence, a multivalent interaction can be strong, even if the individual bonds are weak. However, much more interestingly, multivalency …
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Surface Engineering of Protein Nanoparticles for Intranasal Delivery
… shown to inhibit the delivery of antigens and nanoparticles to nasal-associated lymphoid tissue (NALT) and lungs. Protein nanoparticles are composed of proteins at high mass-to-carrier ratio, while allowing for biocompatibility and tunable physiochemical properties. They have been demonstrated …