Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"protein modelling"”.
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Hepatitis B core (HBc) virus like particle (VLP) as a platform for innovation of chimeric adjuvant-free VLP vaccines targeting oncoviruses
… with non-chimeric HBc VLP. Computational protein modelling was employed to assist the understanding of the possible cause for the differences. Results indicate that the stability of chimeric HBc VLP vaccines was related to the hydrophobicity of chimeric HBc monomers. The stability of …
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In silico-aided design, build and test of synthetic proteins
Since the discovery of proteins in 1838, the field of protein engineering and our understanding of proteins have improved exponentially. Synthetic proteins have found applications in various biomedical, food and material-based settings. This rise in synthetic proteins was complemented with the …
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Multicomponent Complexes, Structural Proteomes, Drug Discovery For Cancer Gene Census And SARS CoV-2
… biology is expensive and time-consuming, a protein modelling algorithm such as a MODELLER can reduce the ample space between the sequence and structural annotation in less time. Thus, solving protein structures with reliable or high accuracy quality assessment can be achieved …
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Isolation and partial characterization of three acetylcholine-gated chloride channels in Haemonchus contortus
… as acetylcholine. Furthermore, in silico protein modelling and agonist docking of all three channels has revealed a unique agonist binding site with several novel residues that appear to be important for binding to cholinergic agonists. Antibodies were generated against the Hco-ACC-1 …
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Machine Learning with Geometric Algebra: Multivectors for Modelling, Understanding and Computing
… geometry optimization; Chapter 3 explores protein modelling and structure prediction; Chapter 4 addresses 3D camera pose estimation and 3D line alignment; Chapter 5 focuses on the solution of partial differential equations for computational fluid dynamics and electromagnetism. We …
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Characterization of the ACC-1 Family of cys-loop ligand gated ion channels from the parasitic nematode Haemonchus contortus.
… site directed mutagenesis and computational protein modelling. I conducted an extensive pharmacological characterization of the following receptors, ACC-2, ACC-1/ACC-2, ACC-1/LGC-46, LGC-46, LGC-39/ACC-1, and LGC-40/ACC-1, and generated homology models for each with various ligands bound. The …
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Quantum Mechanically Derived Biomolecular Force Fields
… and subsequently transferred to model large proteins. Here, we look to challenge this assumption and create a new class of QUantum mechanical BEspoke (QUBE) biomolecular force fields. QUBE is based around the use of atoms-in-molecule electron density partitioning to derive the non-bonded …
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Rational Identification of Neuropilin-1 Inhibitors: From Deep-Learning to Drug Repurposing
… (NRP2)—are type I transmembrane glycoproteins with multifunctional extracellular regions. NRP1 functions as a multifunctional, non-enzymatic co-receptor that potentiates signalling from vascular endothelial growth factor (VEGF), Semaphorins, transforming growth factor beta (TGF-β) and …
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Computational discovery and modelling of tandem domain repeats in proteins
Domains are functional and evolutionary units of proteins that typically fold into stable globular structures. A small subset of natural multidomain proteins contain large arrays of nearly identical domains repeated in tandem, challenging some of our assumptions about protein folding and evolution. …