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Showing 1 to 15 of 15 for “"protein materials"”.
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Design Strategies for Dynamic Self-assembled Protein Materials
… has driven research into bio-inspired materials where scientists investigate the complex relationship between sequence, structure and function of these materials. A good illustrative example of the effect that hierarchical structure can have is a brick wall. Bricks are laid so that the …
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Size-dependent mechanical properties of beta-structures in protein materials
Protein materials such as spider silk can be exceptionally strong, and they can stretch tremendously before failure. Notably, silks are made entirely of proteins, which owe their structure and stability to weak molecular interactions, in particular, hydrogen bonds (H-bonds). Beta-structures, a …
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Multiscale modeling and simulation of deformation and failure mechanisms of hierarchical alpha-helical protein materials
Alpha-helical (AH) protein structures are critical building blocks of life, representing the key constituents of biological materials such as cells, hair, hoof and wool, where they assemble to form hierarchical structures. AHs play an important mechanical role in biological processes such as …
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Elastin-like polypeptide (ELP) tags for self-assembly and high-throughput processing of functional protein materials
… and catalytic capabilities of globular proteins makes these biomolecules promising candidates in a broad array of applications, including industrial production of commodity chemicals, point-of-care diagnostics, and therapeutics. Self-assembly of globular protein-polymer bioconjugates …
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Controlled self-assembly of natural proteins into hierarchically structured functional materials
Protein self-assembly offers key strategies for nature to generate high-performance and multifunctional proteinaceous materials. Inspired by nature’s approach, there is growing interest in the exploitation of self-assembled protein structures as a basis of artificial protein materials. To this end, …
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Order and Disorder in Protein Biomaterial Design
<p>Crystalline and amorphous materials have been extensively studied for their interesting properties, but they comprise a very small portion of the total materials space. The properties of most materials are a consequence of the interactions between their ordered and disordered components. This …
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Methods and Applications of Computational Design in Multiple States
… flexibility and stability is a key property of proteins, contributing to the vast area of structures and functions observed in nature. Flexibility arises from the complex energy landscape that determines the available conformational states of a protein. Over the past two decades, our ability to …
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Application of Functional Amyloids in Morphological Control and in Self-assembled Composites
Amyloids are self-assembled protein materials containing beta-sheets. While most studies focus on amyloids as the pathogen in neurodegenerative disease, there are instances of "functional" amyloids used to preserve life. Functional amyloids serve as an inspiration in materials design. In this …
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Structural heterogeneity in silk fibers and its effects on failure mechanics and supercontraction
Spider dragline silk is a protein material that has evolved over millions of years to become one of the strongest and toughest natural fibers known. Silk features a heterogeneous structure that comprises [beta]-sheet crystals embedded in an amorphous matrix. However, it is not fully understood how …
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Interactions governing the self-assembly of globular protein-polymer block copolymers
Engineering enzymes and other proteins into biocatalysts or bioelectronic devices has the potential to lead to a new generation of energy-generating and energy conversion technologies. Controlling the hierarchical structure of protein materials from the nanoscale single molecule level up to the …
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Methods for study and manipulation of protein self-assembly
The self-assembly of soluble proteins into amyloid aggregates is a mechanism which can be observed in processes that are functional or disease-associated. The resulting fibrillar structures can be formed from a variety of different proteins, but all share a β-sheet rich architecture and a variety …
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Smart Nanomaterials from Repeat Proteins and Amyloid Fibrils
Protein-based materials are an important area of research for various reasons. Natural protein materials such as spider silk have mechanical properties which compare favourably to artificial or inorganic materials, and in addition are biodegradable and can be produced from easily available …
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An experimental study on adhesive or antiadhesiveand strong bio-inspired nanomaterials
… Torino, the Division of Dental Sciences and Biomaterials of the Department of Biomedicine at the University of Trieste, the Physics Department of the Politecnico of Torino, the Toscano- Buono Veterinary Surgery in Torino and the Department of Human and Animal Biology at the University of Torino. …
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Protein Engineering for Biomedical Materials
The inherent design freedom of protein engineering and recombinant protein production enables specific tailoring of protein structure, function, and properties. Two areas of research where protein engineering has allowed for many advances in biomedical materials include the design of novel protein …