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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"protein localization"”.
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Protein localization during the cyanobacterial circadian cycle
… depends only upon the interactions between three proteins - KaiA, KaiB, and KaiC. As such, the cyanobacterial circadian clock provides a unique opportunity to study complex dynamics that can result just from the interactions between three proteins and how the signal from this core oscillator is …
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Network Based Prediction of Protein Localization Using Diffusion Kernel
… of algorithms for predicting subcellular localization of both monoplex and multiplex proteins. Most of current localization prediction algorithms employ features derived from protein sequence data and external functional annotations such as gene ontology or physicochemical properties. …
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Characterization of Neuronal Anillin and Borg Protein Localization and Function
Septins are filament-forming proteins that scaffold a host of proteins to their sites offunction. One such protein is anillin, that along with septins, mediates cytokinesis duringcell division. Research to date has focused on characterizing the role of anillin duringcytokinesis. Interestingly, …
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Mechanisms of Asymmetric Protein Localization in Drosophila Embryonic Neural Stem Cells
… of lgl and dlg mutants, all basal targeted proteins become uniformly localized but distributions of the apical proteins are unaffected. In neuroblasts, Lgl protein is uniformly distributed at the cell cortex, and its cortical attachment is dependent on Dlg's apically enriched localization. …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… axon. Due to their distinct functions, precise protein localization within neurons is essential for maintaining neuronal homeostasis. Certain proteins exhibit notable enrichment in axon terminals, where they exert pivotal influences on neuronal function, morphology, and survival. Dual Leucine …
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Dynamics of Agglutinin -Like Sequence (Als) Protein Localization on the Surface of Candida Albicans
… ALS gene family encodes large cell-surface glycoproteins associated with C. albicans pathogenesis. Als proteins are thought to act as adhesin molecules binding to host tissues. Wide variation in expression levels among the ALS genes exists and is related to cell morphology and environmental …
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Dynamics of Agglutinin-Like Sequence (Als) Protein Localization on the Surface of Candida Albicans
… ALS gene family encodes large cell-surface glycoproteins associated with C. albicans pathogenesis. Als proteins are thought to act as adhesin molecules binding to host tissues. Wide variation in expression levels among the ALS genes exists and is related to cell morphology and environmental …
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Patterning the Mud Snail Ilyanassa obsoleta: The Role of Cell Signaling and Asymmetric Protein Localization
… by 3D/4d. Therefore, I hypothesized that proteins are asymmetrically bequeathed to the inducing D lineage cells by the polar lobe. To test this hypothesis, I compared global protein differences between two cell stage intact embryos, lobeless embryos, and isolated polar lobes by …
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The agarase system of saccharophagus degradans strain 2-40 : analysis of the agarase system and protein localization
… enzymes AgaA, AgaB, AgaC, AgaD and AgaE. These proteins contain glycoside hydrolase domains GH16, GH50 and GH86. S. degradans is the only organism known to collectively encode agarases with at least one of these domains. Unusual for agarases, AgaB and AgaE also contain multiple type-six …
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Evaluating convolutional neural networks and transformer architectures for image-based prediction of protein localization in eukaryotic cells
Background: Accurate prediction of protein subcellular localization is critical for understanding protein function and guiding experimental research. Recent advances in deep learning have enabled high-throughput image-based methods to tackle this problem by leveraging large-scale immunofluorescence …
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The Cytoplasmic Domain of Membrane-type 1 Matrix Metalloproteinase is Required for its Survival-Promoting, but not its Migration-Promoting Function in MCF-7 Breast Cancer Cells
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a multifunctional protease that degrades proteins during cell migration, and influences cell survival. Both the protein localization and signal transduction capabilities of MT1-MMP depend on its cytoplasmic domain (CD), indicative of a diverse …
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The interaction of ELKS with Ca2+ channel β subunits may contribute to active zone organization
… we report a novel interaction between the CAZ protein family ELKS and VDCC β subunits. We found that two isoforms of ELKS (ELKS2 and ELKS1b) and two isoforms of VDCC β subunits (β1b and β4) co-immunoprecipitated. Using fluorescent immunohistochemistry, we observed colocalization between ELKS1b …
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Examination of auxin transport and root development in the scd1-1 mutant in Arabidopsis thaliana
… plant cells via asymmetrically localized carrier proteins. This polarity is believed to be established and maintained by vesicular delivery and endosomal cycling of these proteins. The SCD1 (stomatal cytokinesis defective) protein has a domain structure that suggests it may function in Rab …
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Expression of microbial rhodopsins in retinal neurons with subcellular targeting motifs: for the study of the structure/function of aii amacrine cells and for vision restoration
<p>Protein-targeting motifs serve as addresses for subcellular protein localization. This feature of targeting-motifs was used to study the retina. The first part of the dissertation reports in the axonless spiking AII amacrine cell of the mammalian retina a dendritic process sharing organizational …
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Deconvoluting Cell-Type Specific 3'UTR Isoform Expression in the Adult and Developing Cerebellum
… translation and stability, as well as mRNA and protein localization. However, it is unclear to what extent alternative polyadenylation regulates these processes uniquely in specific cell types. Using a newly developed technique, termed conditionally-tagged poly(A) binding protein-mediated mRNA …
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Využitie transgénnych rastlín pri štúdiu funkcie rastlinných génov
… the expression. In addition, gene expression and protein localization can be analyzed...
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Dhhc5 Regulates Beta-Adrenergic Signaling In The Heart Through Palmitoylation of G Alpha Proteins
… that plays an important role in regulating protein localization, trafficking, and stability. Recent studies have shown that some proteins undergo extremely rapid palmitoylation/depalmitoylation cycles after cellular stimulation supporting a direct signaling role for this posttranslational …
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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
<p>Lipidation of proteins regulates many cellular processes such as signaling transduction and membrane sorting by modulating protein localization and proteinprotein interactions. As such, defects in protein lipidation can render host cells more susceptible to microbial infection and are also …
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Chemi-Optogenetics: Photoactivatable Probes To Control Protein Proximity And Cellular Processes
… the biological specificity of self-labelling proteins (i.e. Halo-tag, SNAP-tag, eDHFR), to develop a series of tools that localize proteins of interest to its target with spatiotemporal precision. The local proximity of a protein and its substrate is sufficient to initiate a desired biological …
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Development, characterization, and application of a charged particle microbeam for radiobiological research
… double-stranded DNA damage, and DNA repair protein localization. These studies will contribute to the understanding of the radiation-induced bystander effect, which is generally defined as the induction of biological effects in cells that are not directly traversed by ionizing radiation.
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