Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"protein kinase activation"”.
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Biochemical Mechanism of Protein Kinase Activation by the Ubiquitination System
… signaling pathway, NF-κB is activated through activation of TAK1-IKK cascade by TRAF6 and Ubc13/Uev1A in a polyubiquitinationdependent manner. Mechanistically how TAK1 is activated by the TRAF6- Ubc13/Uev1A dependent polyubiquitination system is unknown. Whether TAK1 and IKK kinases can be …
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The effect of metformin on vascular function and AMP-activated protein kinase activation in Type 2 diabetes
… AMPK activity was assessed using a peptide kinase assay and the quantification of phosphorylation of the AMPK substrate, acetyl-CoA carboxylase (ACC) in HAECs incubated in rosiglitazone, phenformin or metformin. Nitric oxide (NO) release was evaluated with a Sievers NO meter. Results: The …
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Differential Impact of VEGF and FGF2 Signaling Mechanisms on Flt1 Pre-mRNA Splicing
… splicing, where one gene gives rise to multiple proteins. Alternatively spliced gene products, although crucial for normal physiology, are also linked to an increasing number of pathologies. Consequently, a growing focus is currently being placed on elucidating the extrinsic cues and ensuing …
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Modulation of Signal Transduction in the Nervous System by Protein Phosphorylation
… brain function. This thesis examines the role of protein phosphorylation in mediating three different molecular mechanisms by which neurotransmitter receptors transduce their signals: chemically-gated ion channels, receptor-linked ion channels and receptor-linked ion pumps. The nicotinic …
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The role of plant extracts on islet function in vivo and in vitro
… insulin secretion was partially associated with protein kinase activation and was independent of classical PKC, CaMKII or cAMP activation.<br/><br/>OSA® was also found to protect β-cells from cytokine-induced apoptosis. Our measurement of caspase-3 and -7 production showed partial reduction in …
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Computational investigation of early events in plant growth signaling
… brassinosteroid signal transduction in terms of protein conformational dynamics. Focusing on the two primary brassinosteroid coreceptors, BRI1 and BAK1, we use a number of computational methods grounded in molecular dynamics simulations with the goal of understanding the physical mechanisms of …
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Novel mechanism of gastric proton pump inhibitor (PPI) : Suppression of Helicobacter-pylori induced angiogenesis and selective induction of apoptosis in gastric cancer cells.
… inhibit growth of tumor cells. And, although activation of mitogen activated protein kinases (MAPKs) by Helicobacter pylori infection is associated with induction of host angiogenesis, which may contribute to H.pylori associated gastric carcinogenesis, the strategy for its prevention has not …
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Multilevel Deregulation of Survival Mechanisms In Npm-Alk+ T-Cell Lymphoma
<p>The anaplastic lymphoma kinase (ALK) is a single chain transmembrane receptor tyrosine kinase that belongs to the insulin receptor superfamily. Other members of this superfamily include the insulin receptor (IR), type I insulin-like growth factor receptor (IGF-IR), and the leukocyte tyrosine …
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The Role of K63-Linked Ubiquitination Cycles In Akt Kinase Activation
<p>Akt (also known as protein kinase B) serves a central regulator in PI3K/Akt signaling pathways to regulate numerous physiological functions including cell proliferation, survival and metabolism. Akt activation requires the binding of Akt to phospholipid PIP3 on the plasma membrane and subsequent …